摘要:

AbstractOne hundred and fifty‐six patients with extremity melanomas of known level or thickness who were perfused prophylactically with l‐phenylalanine mustard (1‐PAM) between January 1974 and December 1978 were studied retrospectively to determine the effect of variation of drug dosage and temperature on regional toxicity and disease control. The median drug dosage of 1‐PAM for 57 patients undergoing axillary perfusion was 0.85 mg/kg (range 0.48‐1.0 mg/kg) and the median dosage was 1.2 mg/kg (range 0.59‐1.69 mg/kg) for 99 patients undergoing iliac perfusions. Sixty‐five percent of patients achieved a maximum skin temperature of between 101d̀ and 102°F during perfusion. Determinate survival in the entire group was 93% at 5 years; 10% of patients developed positive regional nodes; and 2.5% developed local or intransit metastases. Based on analysis of other series of patients with extremity melanoma with equivalent Clark's level 5‐year determinate survival might be expected to be between 65 and 80%. The expected incidence of nodal metastases should be 19.1‐24.0% and the incidence of local and intransit metastases should be 3‐6%. While this series suggests a survival advantage for a series of extremity melanomas treated by regional chemotherapy when compared to other series treated by wide excision ± regional node dissection, the results obtained were independent of dosage of drug administered or maximal temperature attained over the range studied. This suggests consideration be given to exploring other dose ranges of drugs and heat in an effort to achieve equivalent control with l

ISSN:0022-4790    

DOI:10.1002/jso.2930270402

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA case of granular cell tumor of appendix occurring in a 58‐year‐old man is described and the literature is revie

ISSN:0022-4790    

DOI:10.1002/jso.2930270403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThere is no information available in the literature on the blood levels of tamoxifen in patients with decreased renal function. As serious side effects of tamoxifen administered at high doses have been reported, a patient with decreased renal function and metastatic breast cancer was studied to determine the blood levels of tamoxifen while under therapy. Since no abnormally elevated levels of tamoxifen were found in this patient during the month of therapy, results of this study indicate that tamoxifen can be administered to patients with some degree of renal impairment without the risk of giving rise to abnormally elevated blood levels.

ISSN:0022-4790    

DOI:10.1002/jso.2930270404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractRadiation therapy in early glottic cancer offers an excellent cure rate with preservation of voice. This study is an analysis of 25 (18%) patients who had failures after irradiation. Ten patients were in stage I (T1N0M0) and 15 patients in stage II (T2N0M0). All patients received megavoltage irradiation with an average dose of 6600 rad, 180 to 200 rad per day, 5 days in a week. Of the failures, 15 patients had the tumor controlled by salvage surgery, laryngectomy being the most common surgical procedure. The median time to recurrence was 23 months. A detailed analysis of the failures, along with a literature review, is done in this paper.

ISSN:0022-4790    

DOI:10.1002/jso.2930270405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractPlasma cell granuloma (inflammatory pseudotumor) has been described most commonly in the lung. Review of the English literature fails to reveal occurrence of such a lesion in the tonsil. We are reporting such a case presenting as a unilateral tonsillar mass in a 63‐year‐old man. A more typical case of plasma cell granuloma of lung is also presented to illustrate the similarity between the tonsillar and pulmonary lesi

ISSN:0022-4790    

DOI:10.1002/jso.2930270406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThe association of low serum cholesterol with colon cancer mortality suggests that low serum cholesterol promotes colon cancer recurrence. We compared cumulative 5‐year recurrence‐free rates of 279 colon cancer patients in relation to serum cholesterol, weight, height, and Quetelet's index. The median value for each variable was used to divide patients into those above the median, or at the median and below. Patients with median and lower serum cholesterol exhibited an 11% lower disease‐free rate at 5 years. Patients above median weight were at significantly increased risk of recurrence in both sexes (76 vs 54%, z = 3.0026, p = 0.003). Progressively decreasing weight was noted with advancing stage in males but not in females. Women above median Quetelet's index were also at significantly greater risk of recurrence (74 vs 52%, z = 2.6109, p = 0.009). Patients above median height were at insignificantly increased risk of recurrence. This study indicates that body weight is a significant prognostic factor for patients with colon c

ISSN:0022-4790    

DOI:10.1002/jso.2930270407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractSprague‐Dawley rats were treated with dimethylhydrazine (DMH) once a week for three months. After a treatment‐free period of five months, they were subjected to minimal colon resection with an end‐to‐end anastomosis. Autopsy (one year after the discontinuation of DMH treatment, and seven months after surgery) demonstrated anastomotic tumors in 50% of the animals. Conclusions were that the carcinogen had induced genetic changes in the nonmigrating stem cells in the colonic crypts and that the chronic reparative process resulting from surgical trauma may have promoted colonic cells to induce tumors at the sutu

ISSN:0022-4790    

DOI:10.1002/jso.2930270408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA patient with squamous cell carcinoma arising from an extensive pilonidal sinus was treated with wide local excision, resulting in an apparent cure over a 1‐year follow‐up period. Review of the literature revealed 32 previously reported cases of this entity. Forty‐four percent of these patients developed recurrences or metastases, and 22% died of their disease. The largest historical treatment group with at least 1‐year follow‐up (19 patients with localized disease) underwent wide excision. Forty‐two percent of these patients recurred or developed metastases. Ultimately, 89.5% of these patients were reported cured, but only five survivors were followed for as long as 5 years. Historical experience appears to identify pilonidal tract squamous carcinoma as an aggressive tumor. The reported success of wide local excision is based on a small number of patients followed for short periods of time. Continued experience with this disease should be reported to verify the adequacy of local excision or identify the need for adjunct

ISSN:0022-4790    

DOI:10.1002/jso.2930270409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThe treatment of metastatic colorectal cancer to the liver has been a significant problem for clinicians in the past. Recent technical advances in infusion systems in the form of the infusaid pump has allowed delivery of chemotherapeutic agents to the liver with great reliability. As more chemotherapy pumps are implanted, undoubtedly, new and unusual complications will occur. This report centers on a patient who developed a disrupted catheter secondary to a high pressure side port injection. It includes a description of the complication, how it occurred, was recognized, and corrected. This report will, hopefully, save other clinicians from encountering similar complications in any of their patients.

ISSN:0022-4790    

DOI:10.1002/jso.2930270410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThe clinicopathologic features of a rare case of renal malignant fibrous histiocytoma is described and compared with similar cases reported in the literature.

ISSN:0022-4790    

DOI:10.1002/jso.2930270411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY