摘要:

AbstractConfirmation of the potential for metastases to metastasize in humans, especially those patients with a well controlled primary, should alter present approaches to patients with malignant disease and isolated recurrences. Reported herein is a case clearly demonstrating the metastatic potential of metastases.

ISSN:0022-4790    

DOI:10.1002/jso.2930080402

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe role of reconstruction in the management of patients with problems related to breast cancer is of increasing importance. Immediate reconstruction is particularly applicable in those situations where prophylactic mastectomy is performed.High‐risk groups who warrant such prophylactic mastectomy and reconstruction include those with florid cyst disease, a strong family history of breast cancer, the finding of lobular carcinoma in situ, multiple previous biopsies, and those who have severe and progressive mastodynia.In those with smaller amounts of breast tissue, reconstruction is based on a double layer of tissue over a graft, one layer consisting of pectoral muscle and the other of breast skin.In those with more abundant breast tissue, the two layers placed over the graft are both derived from skin flaps, the inner layer a free, denuded dermal graft from the inferior flap and the second layer, the superior breast skin flap itsel

ISSN:0022-4790    

DOI:10.1002/jso.2930080403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractA case of hemangiopericytoma arising in the urinary bladder is presented. Initial symptoms included hematuria and frequency of urination. Hemangiopericytoma is a vascular tumor of pericyte origin which occurs primarily in several organs and can be benign or malignant. Reports in the literature of genitourinary system involvement are reviewed. It is concluded that genitourinary tumors of this type should be considered malignant and treated aggressively.

ISSN:0022-4790    

DOI:10.1002/jso.2930080404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe immune reactivity of 100 head and neck cancer patients was studied by means of DNCB, candidine, blastic transformation with PHA, and lymphocyte counts.DNCB reactivity was strong in only 21% of the population and was found impaired in patients with advanced primitive tumors, with more than one primitive tumor, and in patients after radiation.Candidine reactivity was impaired in bigger primitive tumors, positive nodes, and advanced stages, as well as in postradiation patients.Blastic transformation was significantly worse in patients over 70 years and tended to be lower in patients with more than one primitive tumor. Good blastic transformation was also lowered in postradiation patients.

ISSN:0022-4790    

DOI:10.1002/jso.2930080405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractSurvival rates for 3,842 Kansas and Missouri patients with carcinoma metastatic at diagnosis who were registered between the years 1945 and 1974 were examined. While there was no improvement in survival comparing the 1945‐1954 and 1955‐1964 decades, there was significant recent improvement in survival when the 1,805 patients diagnosed from 1945 to 1964 were compared to 2,037 patients diagnosed from 1965 to 1974. It was concluded that even in this particularly unfavorable presentation of cancer, there has been definite improvement in survival in the past dec

ISSN:0022-4790    

DOI:10.1002/jso.2930080406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractHeparinless venoarterial bypass (HL‐VAB) was carried out in 16 sheep for 6 days, by means of a closed circuit tubing coated with nonthrombogenic polyurethane‐polyvinyl‐graphite (PPG) and a roller pump. Nine experiments were completed uneventfully. Seven sheep died during bypass. The causes of death were pneumonia (2), caseous granulomatous lung abscess (3) or abdominal abscess (1), and thromboembolism (1). The last complication was caused by inadvertent trauma to the PPG coating at the time of tubing connection.In the animals in which HL‐VAB was uneventful, no significant changes were noted in the hematologic studies including white blood counts, platelet counts, hematocrit, plasma fibrinogen levels, prothrombin time, thrombin time, activated partial thromboplastin time, Factors V and VIII, and free plasma hemoglobin levels.Inconsistant changes in the above parameters were noted in the animals which died of complications.In conclusion, prolonged HL‐VAB has no adverse effects on blood coagulation

ISSN:0022-4790    

DOI:10.1002/jso.2930080407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractThe reed fistula method is under development as a method of voice restoration in patients who have undergone laryngopharyngectomy. Introducing extrinsic sound into the pharynx involves a series of biomedical engineering problems. The approaches to solution of these problems are covered in the present article.

ISSN:0022-4790    

DOI:10.1002/jso.2930080408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractA patient with simultaneous metachronous carcinoma and polyps of the large bowel is presented. The importance of carcinoma as a predisposing cause to perforation during barium enema is stressed. In view of the considerable incidence of recurrent large bowel tumors, careful routine follow‐up studies should be undertaken and extreme caution exercised during the barium enem

ISSN:0022-4790    

DOI:10.1002/jso.2930080409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractClassifications of generalized carcinoma of the breast were based up to now on factors of definitely proven prognostic significance. These classifications are very useful in defining prognosis, but they help only to a limited extent in selecting treatment. We are proposing a new classification of three groups for generalized carcinoma of the breast according to objective response to therapy: to (a) responders, (b) nonresponders, and (c) patients with static disease. It is pointed out that in some cases there is discrepancy between prognosis and response to therapy, as some patients with “poor prognosis” respond dramatically to treatment while others with “good prognosis” do not respond to any type of treatment and treatment is actually harmful. It is also pointed out that our classificaiton has a dynamic meaning, as a patient can switch from one group to another. The proposed classification might be of more help in deciding the therapeutic man

ISSN:0022-4790    

DOI:10.1002/jso.2930080410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY

摘要:

AbstractSeveral human prostatic tissues have been examined for possible particles and associated DNA polymerizing activity generally associated with the C‐type RNA tumor virus family. Partially purified tissue extracts, when centrifuged to equilibrium in sucrose gradients, yield fractions which contain actinomycin D resistant, endogenous DNA polymerase activity; this activity bands at a density of 1.15‐1.18 gm/cm3. Further analysis of the endogenous products by sucrose gradient sedimentation suggested the presence of high molecular weight RNA:DNA hybrids generally felt to be indicative of a faithful copy of a lengthy stretch of viral specific RNA. However, most of the DNA products synthesized in these endogenous reactions sedimented in much lower molecular weight regions of these sucrose gradients. Clearly, the relative distributions of “high” and “low” molecular weight products could critically depend on the nuclease content of the subcellular fraction under study, and the prostate may be relatively enriched in nucleases. Further, oligo (dT) stimulated the endogenous DNA polymerase activity contained in these extracts, and omission of one of the DNA precursor nucleotides depressed it. Thus, it seems unlikely that terminal transferase activity, rather than genuine DNA polymerization, was being measured primarily. Because of the spectrum of molecular weight classes formed by these DNA:RNA hybrids, as well as their apparent presence in normal prostatic tissue, we find it difficult to ascribe their presence with certainty either to the presence of typical C‐type RNA viruses or to the exclusive behavior of the neoplastic prostatic tissue. Thus, our studies lend support to the growing evidence for functions similar to those of C‐type RNA viruses being relatively widespread in human tissues without the apparent necessity for a possible etiologic role in neoplastic production (Strand and August, 1974; Sherr et al., 1974). At the same time, our current studies emphasize the need for caution in drawing conclusions from results utilizing probes generally felt quite useful in scoring for presence of virus in lower animals at least in the

ISSN:0022-4790    

DOI:10.1002/jso.2930080411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1976

数据来源: WILEY