摘要:

AbstractA primary melanoma of the small intestine is reported. A possible explanation of its origin according to the APUD cell concept is suggested. This concept may lessen the doubts and confusion whenever an intestinal melanoma is discovered and a primary tumor at one of the more common sites can reasonably be excluded.

ISSN:0022-4790    

DOI:10.1002/jso.2930100402

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractPreoperative and postoperative studies of peripheral B and T lymphocyte counts were accomplished in 21 patients. Diagnoses included 10 carcinoma of the breast, 3 sarcoma, and 8 benign diseases. On postoperative day one and two, an increase in B‐cellpercentagewas observed in the majority of patients tested. However, there was a decrease in total lymphocyte count and fast‐reacting T lymphocytenumberson postoperative day one, especially in patients who had intraabdominal operations. All the lymphocyte counts returned to preoperative range within one week. Pertinent reports in the literature were reviewed and discus

ISSN:0022-4790    

DOI:10.1002/jso.2930100403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractIt has been observed that patients with metastatic brain lesions developed neurologic symptoms when given Corynebacterium parvum. To obtain more information in patients with intracranial mass lesions, intracranial pressures (ICP) were measured or observed in six patients undergoing C. parvum therapy.All patients except two (one previously shunted, one recently operated) demonstrated a profound increase in ICP. It is presumed that either edema is formed within brain and tumor tissue (inasmuch as neurologic deterioration has not been observed in patients without an intracranial lesion) or transient increases in cerebral blood flow adversely alter an already compromised intracranial volume. Surgical decompression of tumor volume or use of Lasix® may abort this response to C. parvum infusion

ISSN:0022-4790    

DOI:10.1002/jso.2930100404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractNine patients with unresectable primary and secondary malignancy of the liver underwent ligation of the hepatic artery (HAL) distal to the gastroduodenal artery as a therapeutic measure. Another patient had a similar operation for hepatic artery aneurysm. Their postoperative liver function tests are studied in detail, and the patterns of change are compared with three other patients who had extensive resection of tissues but without HAL.It appears that liver function tests rarely became abnormal after major operations, whereas HAL produced an immediate rise of lactic dehydrogenase and transaminase (up to 5–60 times normal value), and creatine phosphokinase (4–15 times normal). All elevated enzymes returned to preoperative levels within a week. Alkaline phosphatase and bilirubin rose mildly after HAL and returned to preoperative range in about one week. However, if the patient had repeated surgical stress, anoxic insult, or maximal loss of the hepatic parenchyma, serum enzymes rose only slightly after

ISSN:0022-4790    

DOI:10.1002/jso.2930100405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractAdjuvant trials in cancer treatment present special problems in statistical analysis. When the primary treatment modality results in a relatively high cure rate and additional methods of treatment are being inserted in an effort to raise the figures to even higher levels, therapeutic benefit can be obscured unless all features of the study are carefully considered. Biologic benefit may easily be masked by the sizable number of patients randomized to receive adjuvant treatment who have no residual tumor and therefore could not possibly benefit therefrom. For example, 50% of patients undergoing “curative” resection for colon cancer survive without evidence of disease beyond the five‐year postoperative period; thus at least half the patients randomized to receive adjuvant treatment (chemotherapy, radiotherapy, immunotherapy) will be disease‐free at the time of randomization and cannot benefit from adjuvant therapy. New methods of assessment of treatment must be developed; otherwise, substantial therapeutic effectiveness may go und

ISSN:0022-4790    

DOI:10.1002/jso.2930100406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractSixty‐five patients were referred for treatment with symptoms resulting from metastatic cancer to the liver from the GI tract. Two groups of patients were analyzed. The first group of 40 patients were subjected to a laparotomy and insertion of a catheter into the hepatic artery and a second group had the catheter inserted percutaneously and a bolus of cancer chemotherapeutic agents injected into the catheter. In both groups, chemotherapy in the form of 5‐fluorouracil was supplemented by internal irradiaton delivered from the intraarterial administration of Yttrium 90 microspheres. Forty percent of the patients who had an indwelling catheter performed at celiotomy manifested an objective response and in 60% a significant subjective improvement occurred. In the 25 patients whose catheter was inserted percutaneously, the response rate was roughly similar, in that 35% demonstrated an objective response and 65% demonstrated a subjective respo

ISSN:0022-4790    

DOI:10.1002/jso.2930100407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA retrospective study of 74 cases of cancer of the mobile tongue and floor of the mouth, diagnosed between 1949 and 1975, with a two‐year minimum follow‐up was undertaken. The lesions were TNM staged, stages I and II accounting for 56 cases (76%) and stages III and IV accounting for 18 cases (24%). The analysis was restricted to the “localized” stage I and stage II lesions. In this group failure occurred in 31 patients, or 55% of the group. Failure at the primary site accounted for 10 of the failures, failure at both primary and cervical lymph nodes accounted for 14, and failure at cervical lymph nodes only accounted for 7 of the failures. The treatment for these “localized” lesions was then analyzed for modality, adequacy, presence or absence of planning failure, and survival. The results indicate the lethal nature of this lesion when inadequately treated and strongly suggest more extensive use of prophylactic therapy to the cervical

ISSN:0022-4790    

DOI:10.1002/jso.2930100408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractEtiocholanolone levels have been measured in both premastectomy and postoperative urines from 86 women with early breast cancer. Levels did not differ between patients subsequently surviving five years following mastectomy and those dying from recurrent disease within this period.

ISSN:0022-4790    

DOI:10.1002/jso.2930100409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractIn a closed colony of approximately one million mice which had been rigidly pedigreed (brother to sister) from a few original mice, three unusual mice have appeared. These three have obviously deviated from what would be expected according to the accepted laws of inbreeding geneity. Thus three unexpected incidences of increased variability have occurred three times in addition to the occasional appearance of new mutations (approximately one in 26,000 mice).The first mouse developed a sudden increase in susceptibility to spontaneous tumors of mammary origin. She became the mother of the well‐known C family used extensively in cancer research.The second mouse clearly exhibited, among clear‐cut altered biological characteristics, several somatic mutations, thus indicating an unstable genetic condition.The third mouse developed a highly significant capacity to regress and eliminate spontaneous tumor tissue.The conclusion is reached that unstable biological states arise occasionally during the process of inbreed

ISSN:0022-4790    

DOI:10.1002/jso.2930100410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA pleural effusion is a frequent complication of malignant disease. Essential to the care of oncology patients is a fundamental knowledge of the pathophysiology and treatment of such effusions. This article discusses the current thoughts concerning the occurrence of malignant effusions, outlines the current available methods and agents employed for control, and presents a modification of the thoracostomy procedure that appears to be more effective than the standard procedure.

ISSN:0022-4790    

DOI:10.1002/jso.2930100411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY