摘要:

AbstractThe records of 508 patients with cancer of the pancreas admitted to Memorial Hospital in New York from 1949 through 1972 were examined. Ten distinctive morphological types were delineated and the pathological features and response to various modes of therapy of the most common type — duct adenocarcinoma — were studied in 380 patients. Median survival was related to: the site of the cancer — it was longer with tumors of the head than those of the body or tail; the size of the tumor — cancers smaller than 3 cm were associated with over twice the survival of those with large tumors; the stage — stage I patients had over twice the survival of those of stages II and III; and the type of therapy employed. Actuarial survival rate at one year was: with no specific therapy, 0%; with chemotherapy, 1%; after palliative by‐pass surgery, 3%; following radiation therapy, 9%; and after all types of “curative” surgery, 21%. The only survivors at five years were in the “curative” surgery group, but these represented only 1% of all patients. Revolutionary changes in diagnosis and therapy will have to occur if significant increase in survival rat

ISSN:0022-4790    

DOI:10.1002/jso.2930100602

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractIn the first of two studies, 48 mice of the conventional CFW strain were sham‐radiated or radiated in utero for 20 minutes daily by 2,450‐MHz microwaves at a dose rate, respectively, of 0 or 35 mW/g during days 11–14 of gestation. All 48 mice were implanted with a homogenate of a lymphoreticular cell sarcoma on the 16th day postpartum and then, commencing on the 19th day, they underwent a series of 36 daily exposures to the sham‐ or to the microwave‐radiation. Fetal exposure to radiation, which elevated dams colonic temperatures by an average of 2.24°C, was associated with a lower incidence of tumors (13% vs 46% for fetally sham‐radiated mice) as verified histologically at necropsy on the 93rd day postpartum. In the second study, 84 CFW mice received the four radiation treatments in utero; 60 mice were sham‐radiated in utero and served as controls. Postnatal radiation was not administered. All 144 mice were implanted with the homogenate on the 16th day postpartum and then were observed for nearly 36 months for development of palpable tumors and for longevity. Tumors initially developed at a lower rate in fetally radiated mice and 2.5 months after implantation the respective percentages of “takes” in sham‐ and microwave‐irradiated mice were comparable to those observed at termination of the first study. Subsequently the rate of tumor induction in radiated mice accelerated, and after the fourth month the final percentage of radiated mice with tumors (46%) slightly exceeded that of controls (40%). Both tumor‐bearing and tumor‐free animals that had been radiated as fetuses lived longer on the average than respective controls. Long‐term augmentation of immunocompetency by in utero hyperthermia is believed to be responsible for the delayed induction of tumors and

ISSN:0022-4790    

DOI:10.1002/jso.2930100603

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA case report is presented in which myxedema coma and inappropriate antidiuretic hormone secretion developed as a result of radiation therapy and surgery to the neck area in a patient with recurrent metastatic squamous cell carcinoma of the floor of the mouth. Laboratory findings of low thyroxine level and the findings of persistent hyponatremia and hypoosmolality of serum in spite of persistent sodium loss in the urine were helpful in diagnosing the problem. Treatment included thyroid hormone replacement and fluid restriction resulting in complete reversal of her condition.We believe that patients with head and neck cancer who have undergone a course of radiation to the neck, and particularly when thyroid function might have been altered by previous subtotal thyroidectomy as part of a curative resection, should be carefully followed with periodic thyroid function assays and serum electrolytes with particular attention to serum sodium values.

ISSN:0022-4790    

DOI:10.1002/jso.2930100604

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractTwenty‐six member institutions of the Central Oncology Group entered 154 patients in this two‐armed, phase III study comparing the effects of adriamycin, bleomycin, and CCNU against a variety of squamous cell carcinomas. The combination of adriamycin and bleomycin produced a 43% overall response rate in primary tumors of the head and neck, which included two complete responses. This compares favorably to the results obtained with methotrexate and other agents previously reported. The combination of adriamycin and bleomycin will probably be the most useful for induction chemotherapy because both drugs have cumulative toxicities and the duration of response to this combination is sh

ISSN:0022-4790    

DOI:10.1002/jso.2930100605

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractSerial CEA levels have been studied preoperatively, and one day, 10–15 days, four months, and eight months after surgery in a group of colon cancer patients who started soon after surgery a protocol of adjuvant immuno(chemo)therapy with Levamisole® and BCG®. Results showed a decrease of mean values of plasma CEA levels from preoperatively to four months after surgery, while eight months after surgery a slight increase was noted. Some of the patients in whom disease recurred showed persistent high levels of CEA, while one patient was consistently a false‐negative notwithstanding a bone recurrence. While the prognostic value of serial CEA determinations is confirmed, the possibility of restarting (or intensifying) a protocol of adjuvant immunochemotherapy given high CEA levels and a negative clinical picture is disc

ISSN:0022-4790    

DOI:10.1002/jso.2930100606

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractDespite major improvements in diagnosis, anesthesia, surgical techniques, and postoperative care, the survival rate for adenocarcinoma of the stomach remains a dismal one. In our series of 109 patients, almost all patients seen were diagnosed too late to effect any kind of surgical care.In the period from January 1964, to December 1974, 122 patients were admitted to Pennsylvania Hospital with a diagnosis of gastric adenocarcinoma. Of the 109 patients followed to their death, only seven survived 5 years; the longest survival was 80 months.Among the 33 patients not resected, median survival was only one month. Of the 74 patients who had surgical resections survival ranged from a median of 5.5 months for those who had total gastrectomy to a median of 8 months for those receiving subtotal gastrectomy.

ISSN:0022-4790    

DOI:10.1002/jso.2930100607

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractMediastinal lymphangioma is an uncommon benign tumor accounting for 0.7 to 4.5% of all mediastinal masses. Lymphangiomas consist of dilated cystic lymph spaces lined by single layers of endothelium and do not undergo malignant change. Most mediastinal lymphangiomas are asymptomatic. There are no specific radiological findings. Surgical excision is the treatment of choice and the prognosis is excellent.

ISSN:0022-4790    

DOI:10.1002/jso.2930100608

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA case of malignant melanoma arising in the rectum is described and the literature is reviewed. The natural history of melanoma of the rectum is distinctive from that of other tumors of the perineal area in that local recurrence is uncommon and systemic dissemination is frequent, with a low cure rate (2/66 in a literature review). Conservative surgical approaches (fulguration, local resection) are recommended in preference to abdominoperineal resection in that palliation is the realistic goal of surgical therapy.

ISSN:0022-4790    

DOI:10.1002/jso.2930100609

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA case of primary hemangioendothelioma is presented. Following autodearterialization, the patient received 5‐fluorouracil orally and total hepatic radiation. To date, 30 months later, he remains alive and active with residual hepatic defect on liver scan, but no indication of progression of disease. Primary malignant hemangioendothelioma is discussed briefly in terms of etiology, pathology, diagnosis, and treatment, and a treatment plan is presented. This case also presented an unusual side effect of 5‐fluorouracil therapy ‐ mononeuritis multiplex ‐ and is presented out of i

ISSN:0022-4790    

DOI:10.1002/jso.2930100610

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractTwenty‐nine patients with grade III or IV astrocytomas were treated with 1,3 bis(2‐chloroethyl)‐1‐nitrosourea (BCNU), 75–100 mg/M2intravenously (IV) for two consecutive days every four to six weeks, in an effort to improve the quality and length of their survival following surgical resection. Twenty‐one of these patients received adjunctive chemotherapy as soon as they recovered from surgery and 18 received concomitant adjunctive radiation therapy as well. Eight patients were treated with radiation therapy after surgery, and BCNU was not added until evidence of tumor growth appeared. BCNU was discontinued and the epipodophyllotoxin. VM‐26, was given at a dose of 100 mg/M2IV weekly when further tumor growth occurred. Patients receiving adjuvant chemotherapy had a shorter mean and median survival than patients receiving BCNU when progression appeared following radiation therapy. Six patients with progressive disease following surgical resection and radiation therapy for grade 11 astrocytoma were treated with BCNU. Improvement or stabilization of neurologic symptoms occurred in four of these patients. This trial of lower‐dose BCNU therapy produced survival rates similar to higher‐dose studies and permitted fewer physician visi

ISSN:0022-4790    

DOI:10.1002/jso.2930100611

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY