摘要:

AbstractSince antiquity, the large bony and fleshy tumors have been calledsarcomas.It was not until after the development of cellular pathology during the middle of the 19th century that sarcomas were separated from carcinomas on the basis of their tissues of origin. This paper traces the growth of these ideas as well as the introduction of effective methods of treatment of the sarcomas.

ISSN:0022-4790    

DOI:10.1002/jso.2930300403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractAtresia and hypoplasia of the bile ducts are the most common congenital biliary anomalies of clinical importance. Surgical correction can help about 10% of these infants. However, surgery should be performed within the first month of life to avoid irreversible liver parenchymal changes. It is difficult to separate the surgical condition, biliary atresia, from conditions in which the trauma of laparotomy should be avoided, such as neonatal hepatitis and other clinically indistinguishable causes of obstructive jaundice. Radionuclide imaging with the99mTc‐labeled N‐substituted iminodiacetic acids (HIDA, PIDIDA, DISIDA, etc) have been helpful in the differential diagnosis of biliary atre

ISSN:0022-4790    

DOI:10.1002/jso.2930300404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSplenic lymphocytes of BALB/c mice immunized with human ovarian carcinoma cells were fused with the mouse myeloma cell line, NS‐1 in the presence of polyethylene glycol, MW 1500. The hybrid cultures were screened by a viable cell‐binding radioimmunoassay (RIA) for the production of relevant antibodies. Hybrids that produced antibodies that bound to the surface of the immunizing cell line and other ovarian carcinoma cell lines, but not to human fibroblast cell lines or erythrocytes and leucocytes isolated from peripheral blood, were cloned twice by the limiting dilution method. Two such clones designated 8C3, of the IgG2a isotype, and 10D6, of the IgG1 isotype, were checked for specificity by a solid‐phase membrane RIA. The monoclonal antibodies (MoAbs) recognized an antigenic determinant present on different human adenocarcinomas such as ovary, breast, endometrium, colon, and stomach. The normal counterpart tissues of these histiotypes showed negligible binding to the MoAbs. The relative specificity of these MoAbs encourage further studies towards their characterization and evaluation as possible diagnostic and therapeutic agents in human c

ISSN:0022-4790    

DOI:10.1002/jso.2930300405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe clinical, immunopathologic, and virologic features of the lymphoproliferative diseases occurring after renal transplantation have been characterized. Clinically, patients may present with an infectious mononucleosis‐like illness or with localized solid tumor masses. These lymphoproliferative diseases have unique histologic features that can be classified as polymorphic diffuse B‐cell hyperplasia (PDBH) or polymorphic B‐cell lymphoma (PBL). Immunologic cell‐typing studies have shown that the majority are polyclonal B‐cell proliferations, but monoclonal B‐cell tumors have also been documented. These B‐cell proliferations may, however, evolve from a benign polyclonal B‐cell hyperplasia to a monoclonal malignant lymphoma. The Epstein‐Barr virus (EBV) has been implicated as the cause of these disorders. Serologic studies frequently demonstrate evidence of a primary or reactivation infection, touch imprints from involved tissue may stain for the presence of EBNA (Epstein‐Barr nuclear antigen), and EBV DNA hybridization studies demonstrate the presence of EBV‐specific DNA sequences within tumor cells. Since EBV induces a polyclonal B‐cell proliferation in vitro and in vivo, the polyclonality of these diseases also implicates EBV. Acyclovir, a new synthetic antiviral agent that inhibits EBV DNA replication may be effective in some patients during the polyclonal growth phase but is ineffective once the tumor evolves into a monoclonal lymphoma. We have identified several factors that may be useful in predicting responsivene

ISSN:0022-4790    

DOI:10.1002/jso.2930300406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractA case of systemic mastocytosis is reported with an observation period of 20 years. During these two decades multiple manifestations of the disease appeared including urticaria pigmentosis, episodic histamine release, gastro‐intestinal involvement and hepatosplenomegaly.The most extraordinary, and possibly unique phenomenon, has been the development of a massive proliferation of large mastocytomas mainly, but not exclusively, limited to the lower extremities. For different reasons (mechanical disability, bleeding, cosmesis), these tumors have required repeated admissions for surgical removal. The most successful technique has involved use of the ultrasonic scalpe

ISSN:0022-4790    

DOI:10.1002/jso.2930300407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractTranslumbar amputation (hemicorporectomy) was first successfully performed in 1961 after cadaver feasibility dissections. It is useful for certain slow‐growing malignancies of the pelvis and perineum and for patients with advanced sepsis involving pelvic bony structures. As indicated by our 20‐year experience, the operation may be rewarded by control of a malignant process (two patients) and/or relief from chronic pelvic sepsis (four patients), survival and discharge from the hospital after lengthy rehabilitation (six patien

ISSN:0022-4790    

DOI:10.1002/jso.2930300408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractSixty‐eight patients at the University of Illinois, Cook County, and the West Side Veterans Administration hospitals underwent pelvic exenteration for advanced pelvic malignancies during the 15‐year period from 1969 to 1984. Thirty‐two had colorectal cancers, eleven cervical, seven bladder, and six vulvar; in twelve the cancers were in miscellaneous pelvic sites. Forty‐five exenterations were done with intent to cure, and twenty‐three for palliation of patients with bulky, necrotic tumors that had caused symptomatic fistulae, local sepsis, chronic bleeding, or severe localized pain. The total 30‐day postoperative mortality was 4.4% (3/68). The 5‐year survival rate of patients who underwent curative exenteration was 33% (median 27 months). Pelvic exenteration appears to be a feasible surgical procedure for a variety of advanced malignancies as well as for palliation of severely symptom

ISSN:0022-4790    

DOI:10.1002/jso.2930300409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractDuring the past 53 years, 105 patients with Wilms' Tumor have been treated at the Children's Hospital of Buffalo. Prospective and retrospective staging of these cases has allowed comparison with other reported series. All‐stage survival improved from 37% with operation alone to 46% with operation and planned radiotherapy. During the past 22 years, with the addition of adjunctive chemotherapy, all‐stage survival is now 80% with lesser stage survival approaching 100%. Participation in the cooperative National Wilms' Tumor Study has brought the most effective proven treatment to the patient in the shortest period of t

ISSN:0022-4790    

DOI:10.1002/jso.2930300410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractThe realm of cancer chemotherapy is complex and often conflicting. The massive use of cytotoxic agents during the past 25 years has now reached a point where major decisions have to be made. The respective roles of regional techniques, systemic therapy for metastatic disease and adjuvant cytotoxic chemotherapy, all need the most careful re‐appraisal. It is important that surgical opinion continues to be expressed and that surgeons continue to participate in the study and practice of cancer chemotherap

ISSN:0022-4790    

DOI:10.1002/jso.2930300411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY

摘要:

AbstractAn attempt has been made in this study to examine the nature and magnitude of the cancer problem in young adults between the ages of 15 and 34 years living in Greater Bombay. The morbidity data utilised for this exercise were obtained from the Bombay Cancer Registry and the mortality analysis was made from the death records maintained by the Bombay Municipal Corporation. In Greater Bombay, the ratio of cancer incidence in this specific group as compared with the total incidence of the disease in the general population was very high in comparison with the Western incidence. The site most commonly affected by cancer in young adults seems to be the lymphatic and haematopoietic tissues in males and breast and cervix in females. The morbidity and mortality rates of the disease in the general population and in children reveal an overall male preponderance, but the situation is found to be totally reversed in young adults. Then again, the incidence as well as the mortality rates appear to decrease with advancing age in children, but in young adults the incidence increases with age. Leukaemia is the most commonly encountered malignancy in the young adult male, followed by cancers of the testes and bones, Hodgkin's disease, and cancers of the brain and connective tissues, in descending order of frequency. In females, breast cancer has the highest incidence followed by cancer of the cervix, leukaemia, and cancers of the ovary and thyroid. When the various registers are ranked according to age‐adjusted incidence rates, the figures for Greater Bombay are seen to be at the lowest levels in both sexe

ISSN:0022-4790    

DOI:10.1002/jso.2930300412

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1985

数据来源: WILEY