ISSN:0022-4790    

DOI:10.1002/jso.2930210402

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractAs a primary feasibility study for the selection of biomarkers for more extended clinical evaluation, 17 potential biomarker candidates were measured in the body fluids of patients with ovarian carcinoma. For comparative purposes, patients were staged and separated into three groups: those considered completely free of disease, those with residual but minimal tumor, and those with advanced disease. Individual markers included plasma carcinoembryonic antigen, serum human chorionic gonadotrophin, urinary β‐aminoisobutyric acid, serum UDP‐galactosyltransferase, and urinary hydroxyproline. Structurally related groups of biomarkers included six modified nucleosides and three polyamines analyzed in urine, and three serum protein‐bound neutral carbohydrates. The respective chromatographic methods developed for these latter biochemical materials enabled all the individual compounds in each group to be quantitated simultaneously in one analytical run. The general frequency and degree of elevation for the total number of biomarkers was directly proportional to increasing tumor burden with specific exceptions, human chorionic gonadotrophin and β‐aminoisobutyric acid. Galactosyl‐transferase was the most frequently elevated in the limited disease categories. Several of the biomarkers were elevated in the majority of patients with advanced disease and appeared potentially superior to carcinoembryonic antigen or human chorionic go

ISSN:0022-4790    

DOI:10.1002/jso.2930210403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractA retrospective analysis of the natural history of 63 consecutive patients with gallbladder cancer during 30 years at a county hospital in Sweden is presented. Dominating symptoms were pain, jaundice, weight loss, and a palpable mass. Fifty patients were subjected to surgery. Forty‐one patients had an extensive tumor spread in the abdominal cavity. Twenty‐six patients were cholecystectomized and in 24 patients biopsy from the tumor was the only measure taken. The gallbladder cancer was occult in four patients. The median survival time was 1 month in patients who underwent autopsy, 2 months in patients who were biopsied and 4 months in patients who were cholecystectomized. The overall 6‐month and 1‐year crude survival rates were 16% and 8%, respectively. Comparison with previous reports regardless of treatment reveals that the prognosis of gallbladder cancer is still dismal and un

ISSN:0022-4790    

DOI:10.1002/jso.2930210404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractSubungual melanoma, a rare and easily misdiagnosed neoplasm, affected 52 patients. The lesion usually appeared as a dark spot under the nail, causing its destruction at a later stage. Diagnosis was missed by primary care physicians in 42% of the cases. Management in the hospital consisted of amputation of the involved finger or toe with or without regional node dissection. The study indicated that proper amputation should be at the tarsometatarsal or the carpometacarpal level. It also showed the node dissection should best be performed at the time of amputation, regardless of whether the nodes are clinically involved or not. Besides nodal metastasis, prognosis is adversely affected by nail destruction caused by the tumor. Subungual melanomas of the fingers have a better prognosis.

ISSN:0022-4790    

DOI:10.1002/jso.2930210405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractTwenty‐seven male patients had been treated surgically for basal cell carcinomas of the temple and cheek. Eighteen tumors were classically nodular, seven cystic, and two cicatricial. A safety margin of 0.5–1.0 cm in nodular and cystic tumors, and 1.0–1.5 cm in cicatricial variety has proven satisfactory. Reconstruction has been achieved by local skin flap: Limberg rhomboid flap for the temple, cheek transposition flap for the anterior portion of the cheek, combined pre‐ and postauricular transposition flaps for the middle part of the cheek and advancement flap(s) with Bürow's triangles for tumours of the preauricular region. Principles and practical points of each flap have been discussed. The proposed safety margins have been enough to clear the lesions as proved by histopathological examination. Cosmetic result has been satisfactory, and there has been no recurrence over a period of 6 months to

ISSN:0022-4790    

DOI:10.1002/jso.2930210406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractThe serum copper/zinc ratio was measured in 44 patients bearing primary large bowel malignancies. Measurements were repeated following removal of the primary tumour and again at the time of development of clinical evidence of cancer recurrence in order to evaluate the clinical value of the ratio to accurately reflect the presence or absence of malignancy. Estimation of serum copper levels do reflect the presence of malignancy, but the copper/zinc ratio is of no added value. As other acute phase proteins have been shown to be superior to serum copper as markers for monitoring of cancer patients, it is concluded that in patients with large bowel cancer, monitoring with serum copper/zinc is of no clinical value.

ISSN:0022-4790    

DOI:10.1002/jso.2930210407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractUtilizing lymphocyte proliferation assay, effects of operation on cell‐mediated immune response to autologous tumor extract were studied in 33 patients with gastric or colon carcinoma. To evaluate the lymphocyte proliferation response to autologous tissue extract preoperatively, the lymphocytes were left in culture for 24–30 hours before addition of the extract while 3 M KC1 extract of autologous tissue was being processed. A significant level (P<0.001) of correlation was observed between stimulation index values to autologous tumor extract added at the initiation of culture and after a 24–30–hour period of incubation. Using this type of assay system, lymphocyte proliferation response to autologous tumor extract was examined immediately before operation and 1, 2, and 4 weeks after operation serially. Data comparing the responses of 20 patients who had curative resection and 13 patients who underwent noncurative resection appeared to fall into three categories in each group. The clinical courses of these patients in each category might clarify the significance of changes in the response following op

ISSN:0022-4790    

DOI:10.1002/jso.2930210408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractA case of leiomyosarcoma of the inferior vena cava of a 46‐year‐old man is presented, and review of 51 cases of this type of malignant tumor is made. The biological behavior of this tumor and various treatment modalities are discus

ISSN:0022-4790    

DOI:10.1002/jso.2930210409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractThis is a retrospective study comparing the results of distal subtotal (DST), total (T), and extended total (ET) gastrectomy in a group of 143 patients with adenocarcinomas of the antrum. Of those, 52 had TNM stage I and II tumors and 91 had stage II and IV tumors. Operative mortality was 10% with DST, 23% with T, and 16% with ET. The incidence of recurrence of the tumor at the gastrectomy site was 26% for DST, 27% for T, and only 9% for ET. In stages I and II, the difference of recurrence in favor of ET was significant (P<0.05). Analysis of survival data without TNM staging showed no significant difference between the three procedures. TNM staging indicated that that surgical treatment, regardless of procedure, salvaged only five out of 91 stage III and IV patients. The choice of procedure made a difference only in stages I and II, where ET was associated with a significantly higher survival than DST (P<0.02). The study suggested that intraoperative staging might be of value in selecting the proper type of gastrectomy. This could be accomplished with node sampling because tumor size corresponds poorly with TNM stage.

ISSN:0022-4790    

DOI:10.1002/jso.2930210410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY

摘要:

AbstractWhether to perform local resection alone (LR) or to combine local resection with ipsilateral radical neck dissection (LR and RND) as primary treatment for carcinoma clinically confined to the tongue is controversial. To compare the outcomes of the two procedures, we reviewed the records of 502 patients treated for carcinoma of the tongue from 1949 to 1974, 128 of whom had no evidence of disease beyond the tongue. Immediate LR and RND was performed in 39; 16 (41%) had recurrences, and 14 (36%) died. On the other hand, 89 patients underwent LR alone; 43 (48%) had recurrences, and 29 (31%) died. All were followed for a minimum of 5 years or until their deaths. There was no statistical difference between the two procedures in recurrence or outcome. The two groups were compared with respect to tumor size according to the TNM classification, and no significant differences in recurrence or survival were apparent. LR alone appears to be adequate primary treatment for patients with no evidence of metastatic disease, provided close postoperative follow‐up is observed. LR and RND may result in increased morbidity and certainly in disfigurement, and fails to improve prognosis or surviva

ISSN:0022-4790    

DOI:10.1002/jso.2930210411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1982

数据来源: WILEY