摘要:

AbstractHemicorporectomy, or translumbar amputation, is a dramatically drastic surgical salvage procedure for patients with uncontrolled locally extensive pelvic‐perineal malignancies. Several successful cases have been reported in the world literature [3–6] and careful perioperative management has been crucial. The case presented is that of a massive recurrent chondrosarcoma of the pelvis with special emphasis on close monitoring and finely tuned supportive care; unusual manifestations of neuroleptic malignant syndrome and of narcotic withdrawal are discus

ISSN:0022-4790    

DOI:10.1002/jso.2930260202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractRetrospective studies of twelve patients with advanced gastric leiomyosarcomas were undertaken to evaluate radical surgical resection and combined modality treatment with regard to the patient survival and symptom palliation. All but one patient were found to have metastases or involvement of adjacent organs at the initial operation. Despite radical resection, multidrug chemotherapy, and radiation therapy, no patient survived beyond the third year. Patients with objective response to chemotherapy and radiation and chemotherapy had a mean survival of 27 months, while those who did not respond survived only 7 months. The longest survival among untreated group was 8 months. Successful palliation of advanced gastric leiomyosarcoma requires early diagnosis, surgical resection and multimodal therapy.

ISSN:0022-4790    

DOI:10.1002/jso.2930260203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA chemoimmunotherapy program designed on the basis of experimental results was administered to 27 patients with stage III carcinoma of stomach following curative resection. The treatment regimen consisted of active immunotherapy with Vibrio cholerae neuraminidase (VCN)‐treated autologous tumor cells admixed with bacillus Calmette‐Guérin (BCG) and chemotherapy with drugs such as cyclophosphamide (CY), mitomycin C (MMC), and 5‐fluorouracil (FU) which proved to enhance the immune response when administered at optimal dose and timing. Then, it was followed by long‐term administration of tegafur (FT) and immunomodulators. This treatment significantly improved survival when compared to that of 41 historical control patients treated with surgery alone (P<0.001). As compared to 31 control patients concurrently treated with a bolus dose of MMC followed by long‐term FT and immunomodulators, survival had a tendency, but not significantly, to be improved in patients treated with this therapy (P<0.1). However, the survival rate at 4.5 years was significantly higher than that of control patients (P<0.01). These results appeared to show that this type of adjuvant combination chemoimmunotherapy may be of benefit for this group of patients with gastric

ISSN:0022-4790    

DOI:10.1002/jso.2930260204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThis report describes our experiences with 12 cases of cavernous hemangioma of the liver. Eight patients were submitted to surgical procedures. Five out of eight underwent liver resections that ranged from simple excision to hepatic lobectomy. Three patients underwent hepatic artery ligation. There were no surgical deaths or any late deaths. Four more asymptomatic patients have been observed for up to 11 years (mean 4.0 years). None of the patients in this group has evidenced intensification of symptoms or any remarkable change of the size of lesions.

ISSN:0022-4790    

DOI:10.1002/jso.2930260205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractAntitumor effect of oral bacille Calmette Guérin (BCG) administration was investigated by both animal experimentation and clinical trials. In animal experiments, orally administered BCG inhibited metastasis of syngeneic tumor from the initial site in caecum to mesenteric lymph nodes. Measurement of chemiluminescent intensity of adherent cells obtained from mesenteric lymph nodes of treated hosts revealed elevated activities of these cells. In the clinical trials it was found that marked histiocytosis occurred in mesenteric lymph nodes of stomach and colorectal cancer patients treated by the oral BCG. The 2‐year survival rate of treated patients with stage IV stomach cancer (44.4%) was significantly higher than that of the untreated patients (6.3%). The results of the present study indicate that the oral BCG administration would be an effective local adjuvant therapy following radical surgery to treat patients with gastrointestinal canc

ISSN:0022-4790    

DOI:10.1002/jso.2930260206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractRadiation enteritis is seen in patients receiving radiation therapy for various pelvic malignancies. Attempts to prevent this have included various surgical as well as nutritional approaches with little success. The use of a polyglycolic acid mesh sling sewn above the pelvic inlet has prevented small bowel descent into the true pelvis in rats and in humans. The technique has been successful in both with no attendant morbidity during an 11‐month follow up. Several patients have received additional doses of radiation therapy that would not have been given if the small bowel were not removed from the area to be irradiate

ISSN:0022-4790    

DOI:10.1002/jso.2930260207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA patient with metastatic malignant fibrous histiocytoma (MFH) achieved a complete remission with polychemotherapy lasting 42+ months. In view of this long‐term survival and two similar prior reports of long‐term survival after aggressive treatment, the goal of therapy for metastatic MFH must be reconside

ISSN:0022-4790    

DOI:10.1002/jso.2930260208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA case of primary lymphoma of the brain is presented. The disease is rare and thus firm guidelines for therapy are lacking. Whole‐brain irradiation therapy, the accepted treatment of choice, when given to a dose of 5000 rads, is associated with improved survival. However, the overall prognosis is poor due to local recurrence in the central nervous system and the tumor's ability to diffusely infiltrate the meninges. Twenty‐six percent of the cases may have positive cerebrospinal fluid cytology. Whether the addition of intrathecal chemotherapy with agents such as methotrexate will improve upon the results obtained with irradiation therapy alone would be an appropriate subject for a cooperative prospective randomized st

ISSN:0022-4790    

DOI:10.1002/jso.2930260209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThe radionuclide bone scans and medical records of 62 patients with osteogenic sarcoma were reviewed to determine the significance of abnormalities demonstrated by the initial scintigraph at sites other than the primary lesion. 94% (58/62) of patients had abnormally increased tracer uptake at sites other than the primary tumor location. Eighty percent (49/62) of patients had abnormal bone scans at the ipsilateral proximal weight bearing joints. Only two of these patients later demonstrated metastatic tumor. Sixty‐one percent (38/62) of patients had abnormal bone scans at joints distal to the primary tumor and none were due to tumor. Five patients ultimately developed osseous metastases at sites that were normal in the original scan. The majority of radionuclide bone scan abnormalities occurring at the time of diagnosis of osteogenic sarcoma at locations distant from the primary tumor site do not represent metastatic diseas

ISSN:0022-4790    

DOI:10.1002/jso.2930260210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA case of tubular adenoma with squamous metaplasia of the sigmoid colon in a 44‐year‐old female is reported. The tumor was a pedunculated polyp with a size of 1.2 × 1.7 × 1.7 cm. Histologically, the tumor showed tubular adenoma with focal squamous metaplasia. Borderline atypia was noted in a part of adenoma without squamous metaplasia and squamous component. It is supposed that squamous epithelial polyp, squamous cell carcinoma, adenosquamous carcinoma, and mucoepidermoid carcinoma may be derived from colonic adenoma with squamous metaplasia. Only six cases of the adenoma with squamous metaplasia of the large intestine have been reported previously in the liter

ISSN:0022-4790    

DOI:10.1002/jso.2930260211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY