摘要:

AbstractA case of synovial sarcoma in the abdominal wall of a 50‐year‐old Iraqi woman is reported. The ultrastructure of the tumor has been studied. Eight other cases of synovial sarcoma in the abdominal wall reported in the English literature up to 1978 have been reviewed.Synovial sarcomas in the abdominal wall tend to occur with a much greater frequency in women, whereas such tumors occurring in the extremities or the neck are more common in men than women.No ultrastructural studies of abdominal wall synovial sarcomas could be found in the English literature. The ultrastructural characters of this tumor are similar to those of such tumors arising in the usual sites and the neck. However, the present study has indicated that the light and dark cells reported by earlier workers are not limited solely to the epithelioid areas but are also present in the spindle cell zo

ISSN:0022-4790    

DOI:10.1002/jso.2930170402

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractIntraperitoneal injections of 2 × 107SH‐Me cells (human metastatic melanoma cells) to 20 Balb/c nu/nu mice (Group A) and 1 × 107cells to 20 mice (Group B) were performed. All animals were studied clinicopathologically. Five animals in Group A were sacrificed serially, revealing marked tumor growth of the melanoma within the peritoneal cavity. These tumors grew in multiple nodular configurations and tumor ascites was present by the third week. The remaining 15 animals in Group A were allowed to progress and seven subsequently died with mouse viral hepatitis (MVH). These animals had suppressed tumor growth. The remaining eight animals died of peritoneal carcinomatosis with survival time of 24.1 ± 5.0 days. Eight of the animals in Group B died of mouse viral hepatitis while the remainder died of peritoneal tumor without distant metastasis. Survival time in these animals was 23.8 ± 2.6 days. Both 2 × 107and 1 × 107tumor cells injected intraperitoneally will constantly produce tumor nodules in non‐MHV‐infected nude mice with similar survival. This experimental model has proven useful for in vivo study to assess the immunoreactivity of melanoma patient cells reactive against target

ISSN:0022-4790    

DOI:10.1002/jso.2930170403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractFour patients with metastatic glucagonoma and one patient with metastatic diarrheogenic islet cell carcinoma of the pancreas were treated with dimethyltriazenoimidazole carboxamide (DTIC), 250 mg/M2daily for five days repeated every four weeks. All patients responded clinically and chemically in one or more ways by a reduction in plasma glucagon levels, improved glucose tolerance, decreased measureable tumor, weight gain, and resolution of necrolytic migratory erythema and diarrhea. This experience and other cases from the literature call for the investigation of DTIC as the initial therapy in metastatic islet cell carcinoma of the pancreas and as being of possible benefit in other tumors of neuroendocrine origin.

ISSN:0022-4790    

DOI:10.1002/jso.2930170404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractMouse hepatitis virus (MHV) infection was found in 15 of 40 athymic mice (Balb/c nu/nu) used in an experimental model designed to study the effect of cell mediated immunity on target human melanoma cells growing in the peritoneal cavity.Most non‐MHV‐infected mice died of peritoneal tumor within predictable periods following injection of the melanoma cells. Twelve of 15 MHV‐infected mice which showed either poor or no tumor growth died of MHV infection, whereas only 3 showed good tumor growth. Peritoneal marcrophages in the ascites from the MHV‐infected mice were greatly reduced in number compared to those in the ascites from the non‐MHV‐infected mice. Although the fibrohistiocytic reaction was more prominent in the MHV‐infected mice, other aspects of spleen and lymph node lymphocytic reactions exhibited no remarkable differences between the two groups. The possible mechanisms whereby MHV infection influences tumor growth in nude mice

ISSN:0022-4790    

DOI:10.1002/jso.2930170405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractNowadays the evaluation of serial carcinoembryonic antigen (CEA) levels represents an important parameter for the prognosis of patients with carcinoma of the large bowel. Changes in CEA values allow the drawing of conclusions regarding the effectiveness of therapy. We have studied 63 patients with colorectal carcinoma that underwent surgical treatment. Serial CEA levels were tested in each patient before surgery and 15 days after. The 53 patients were considered surgically cured; and among these 7 did not have a significant decrease of CEA values after surgery. The percentage of recurrences among these patients has been 71.4%; meanwhile patients who showed a decrease of CEA values below cutoff values had recurrences only in 17.3% of cases. For this reason is our opinion that patients considered surgically cured who have postoperative high CEA levels cannot be considered really cured from a biological point of view.

ISSN:0022-4790    

DOI:10.1002/jso.2930170406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractThe clinical need for central venous cannulation has been well established. The usual route for catheter placement is by either the subclavian or internal jugular vein. No randomized, prospective evaluation has been yet conducted to determine which of these approaches, if either, is better with respect to reliability, placement, and frequency of nonseptic complications. One hundred consecutive patients requiring elective central venous cannulation were randomized to either the subclavian or internal jugular route. Successful venipuncture and catheter passage were significantly more common with the subclavian route, and in the absence of special clinical situations, it appears to be the route of choice.

ISSN:0022-4790    

DOI:10.1002/jso.2930170407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractCancer incidence and mortality rates of Chinese in China (Shanghai, Kwangtung), Hong Kong, and the United States (San Francisco, etc.) are presented. The rates for the U.S. white population are included for comparison. Additional mortality rates of Chinese in Japan and incidence rates of Chinese in Singapore and British Columbia are also available. Such statistics emphasize both the distinctions and the similarities in cancer problems among chinese living abroad and Chinese living in China. Some ethnic and cultural differences, as well as differences in age, site distribution, and histological subtype, of certain cancers are discussed.

ISSN:0022-4790    

DOI:10.1002/jso.2930170408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractNine previously untreated patients with stage D prostatic carcinoma received megestrol acetate 40 mg orally three times daily. Responses included five partial regressions, two stabilizations, and two progressions. Duration of response ranged from 3 + to 33 + months, with a mean of 11.7 months and a median of 12 months. Three of five patients who had failed prior hormonal therapy remained objectively stable while receiving megestrol acetate. No gastrointestinal toxicity, gynecomastia, fluid retention, or thromboembolic complications were observed during treatment. Weight gain of 5 to 51 pounds occurred in seven of 14 patients.

ISSN:0022-4790    

DOI:10.1002/jso.2930170409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractTransperineal biopsies of prostate carcinomas were histochemically stained with estradiol‐3‐dansylate, a fluorescent stain. About half of the carcinomas were stainable but carcinomas with distant metastasis showed a lower staining percentage than carcinomas without distant metastasis. The combination of a positive estradiol‐3‐dansylate staining and a well‐to‐moderate differentiation of the tumor seems to indicate a low chance of developing metastasis in the future. If this correlation could be confirmed in following studies, it would mean that about one‐third of patients with localized prostatic carcinoma may be indicated by a transperineal biopsy with this method, as having a low risk for futu

ISSN:0022-4790    

DOI:10.1002/jso.2930170410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractAdministration of 0.2 ml of a 1.25% solution of phenylhydrazine (PHZ) and 500 rads of X‐irradiation to BALB/c mice produced a prompt and severe reduction to hematocrit with a resultant increase in plasma levels of erythropoietin (Ep). By also giving mice treated with PHZ and irradiation an ascites from of a transplantable sarcoma, the amount of recoverable material rich in Ep could be greatly increased because ascitic fluid contained levels of Ep comparable to plasm

ISSN:0022-4790    

DOI:10.1002/jso.2930170411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY