摘要:

AbstractSixty‐four patients (mean age, 51 years) had mastectomies which were synchronous and bilateral. Sixty‐one premastectomy biopsies (bilateral, 34 and unilateral, 27) demonstrated the following: invasive carcinoma, 17; noninvasive carcinoma, 24; combination of above, 10; and benign disease, 10. Twenty‐two patients had bilateral mastectomy because of bilateral positive biopsy. Twenty‐nine patients with unilateral carcinoma on biopsy had bilateral mastectomy. Thirteen patients had bilateral mastectomy despite benign disease only on biopsy (10) or no biopsy (3). Ten unexpected carcinomas (34%) were found in the contralateral breast in the 29 patients with carcinoma diagnosed on unilateral biopsy. The biopsy pathology of these 10 spicemens was invasive ductal carcinoma in 1 and multifocal, noninvasive carcinoma(ductal, 3 and lobular, 6) in 9.An unexpected carcinoma may be found in the contralateral breast in a significant number of patients who are selected for bilateral mastectomy, particularly if the selection is on the basis of a noninvasive, lobular histology. Bilateral mastectomy may be appropriate for such patients, particularly when complicated by a strong family history and breasts which are difficult to assess by physical or mammographic exam

ISSN:0022-4790    

DOI:10.1002/jso.2930590202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractFifty‐four previously untreated patients with locally advanced resectable squamous cell carcinoma of the head and neck (SCCHN) were enrolled into a prospective randomized controlled trial to evaluate whether induction chemotherapy improves the disease‐free survival compared to the standard treatment (surgery + radiation). Thirty patients received chemotherapy, which consisted of cisplatin 20 mg/m2day 1–5, bleomycin 10 mg/m2, continuous infusion from day 3–7, and methotrexate 40 mg/m2given on day 15 and day 22. The cycle was repeated on day 29 for two cycles. Twenty patients completed chemotherapy courses. Overall response rate was 77% (23 of 30). No survival improvement was observed. Kaplan‐Meier analysis indicated survival (and 95% confidence interval) at 3 years was 57% (29%‐84%) for the control group and 60% (34%‐87%) for the chemotherapy group, and 57% (29%‐84%) and 45% (12%‐78%) at 4 years (P = 0.736). However, patients who had a complete response were significantly better in terms of long‐term survivors (5 of 7 patients were still alive), in contrast to patients who had partial responses among whom only 4 of 16 were alive. Toxicities of this induction protocol are tolerable; one chemotherapy‐related death occurred from profound thrombocytopenia. If efforts in determining a chemotherapy‐sensitive patient were successfully established, along with a better sequence and the discovery of new and safter drugs, survival of SCCHN

ISSN:0022-4790    

DOI:10.1002/jso.2930590203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractThe effect of the lipophilic, cationic dye, Rhodamine‐123 (Rh‐123), on prostate cancer in rats, and on three tumor cell lines in vitro is reported here. The general toxicity of Rh‐123 in mice has been found to be minimal. Lobund‐Wistar (L‐W) rats with the autochthonous prostate cancer of Pollard were treated for six doses with Rh‐123 at a dose of 15 mg/kg subcutaneously every other day. Microscopic examination of the tumors revealed cellular and acinar destruction. The effectiveness of Rh‐123 as a cytotoxic agent was tested by clonogenic and viability assays in vitro with three human prostate cancer cell lines. Severe (60‐95%) growth inhibition was observed following Rh‐123 exposure for 2–5 days at doses as low as 1.6 μg/ml in all three prosta

ISSN:0022-4790    

DOI:10.1002/jso.2930590204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractForty‐seven patients with renal cell carcinoma with tumor thrombus extension to the renal vein or inferior vena cava (IVC) were treated surgically over a 10‐year period. There were 41 males and 6 females with a mean age of 45.7 years. Thirty‐three patients had right‐sided and 14 had left‐sided tumors. Patients with renal vein or infrahepatic IVC thrombus were treated with radical nephrectomy with tumor thrombus excision after achieving conventional vascular control over the IVC and the opposite renal vein. Four patients with retrohepatic IVC thrombus were treated with venacavotomy and thrombectomy after achieving vascular control above the thrombus but below the hepatic veins while two other patients with retrohepatic and one with suprahepatic thrombus required a bifemoroatrial partial venous bypass prior to tumor thrombectomy. There was one postoperative death due to pulmonary embolism. The actuarial 5‐year survival for all patients with venous extention was 50% and the median survival was 4.35 years. Perinephric spread and lymph node metastases were significant prognostic factors affecting survival. This suggests that it is the locoregional spread of renal cell carcinoma rather than the level of the thrombus which governs the prognosis of patients with tumor thrombus extension to the renal

ISSN:0022-4790    

DOI:10.1002/jso.2930590205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractWe investigated and compared the DNA content between primary and metastatic lesions from 30 colorectal cancer cases. The findings were only diploid in 2 cases (6.7%) and only aneuploid in 18 cases (60.0%). On the whole, the DNA ploidy agreed in 20 cases (66.7%) between both lesions. In the 18 cases with only aneuploid tumors in both lesions, the DNA index tended to be larger in the metastatic lesions than in the primary lesions. In contrast, a variation in the DNA ploidy was observed in 10 cases (33.3%). These findings show that DNA ploidy tends to remain stable during metastasis in many cases of colorectal cancer, although the DNA index did tend to be larger in metastatic lesions than in primary lesions. The existence of intertumoral heterogeneity in the DNA ploidy also shows that specimens should be investigated from both lesions in order to obtain more accurate information on the tumor and its biological behavior.

ISSN:0022-4790    

DOI:10.1002/jso.2930590206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractIn our previous study on liposome‐mediated transfection of the human interferon‐β (HuIFN‐β) gene into subcutaneously implanted human gliomas in nude mice, we found that HuIFN‐β was produced and secreted by the tumor cells and that the growth of solid tumors was completely inhibited. The present study investigated the growth‐inhibitory effect of liposomes containing the HuIFN‐β gene inserted into a vector (PSV2IFN‐β) on T9 rat glioma implanted into the brains of rats. Tumor cells and liposomes containing pSV2IFN‐β or other additives were simultaneously injected into the brains of rats. HuIFN‐β was detected in solid gliomas growing in the brains of rats injected with liposomes and magnetic resonance imaging (MRI) showed that tumor growth was inhibited. In addition, the latent period until the appearance of neurological symptoms was significantly prologed in rats treated with liposomes containing pSV2IFN‐β. However, the survival time of the treated rats was not significantly increa

ISSN:0022-4790    

DOI:10.1002/jso.2930590207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractThe role of pulmonary metastasectomy for metastatic soft tissue sarcomas is examined by reviewing the recent (1978‐1994) English language literature. There are no prospective studies that contain an appropriate control group, and only one retrospective study contains a matched control group. In those few studies that provide greater than 5‐year survival data, the survival curve still has a steep slope and few patients are alive at 7 years. In most studies only one or two patients are at risk at 5 years or more. Projected survival is therefore statistically questionable. It is currently impossible to know what is the impact of the surgical procedure over and above the natural history (biology) of the tumor. A randomized, prospective study, as suggested a decade ago, is still needed. While there may be some merit to pulmonary metastasectomy in highly selected patients, aggressive pulmonary metastasectomy does not seem justified by the available d

ISSN:0022-4790    

DOI:10.1002/jso.2930590208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractCPT‐11‐resistant human gastric and colonic xenograft lines were established by direct intratumoral injection of CPT‐11 into subcutaneous SC‐1‐NU and CC‐2‐NU tumors in nude mice once a week for 10 months. The resistance of these xenograft lines to CPT‐11 was confirmed by growth inhibition rate, to be 36.3% and 45.4%, respectively, compared to each parent cell line. DNA topoisomerase I activity of the nuclear extracts of SC‐1‐NU/CPT‐11 and CC‐2‐NU/CPT‐11, as assayed by relaxation of supercoiled DNA Col‐E1, was significantly less than those of the parent lines. The cellular levels of topoisomerase I in those resistant lines measured by Western blot analysis were 0.57‐ and 0.79‐fold lower than those of the parental lines, respectively. However, the activity of DNA topoisomerase II of those resistant cell lines assayed by decatenation of kinetoplast DNA was higher than that of the parental lines and the cellular levels of topoisomerase II in the resistant lines measured by Western blot analysis were 10.8‐ and 8.1‐fold higher than those of the parent lines. Intracellular accumulation of CPT‐11 in CPT‐11‐resistant tumors was not changed as compared to that of the parental lines, but hydrolysis of CPT‐11 to more act

ISSN:0022-4790    

DOI:10.1002/jso.2930590209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractBetween 1983 and 1994, we treated 51 patients with esophageal varices and portal trunk and main branch invasion of hepatocellular carcinoma, using endoscopic injection sclerotherapy. Variceal bleeding was controlled in 28 of 29 patients (96.6%), esophageal varices were completely eradicated in 28 (54.9%), and only 2 of 28 (7.1%) bled from small, dilated, venous vessels after eradication. The cumulative nonbleeding rate at 3 years was 87.5%. Death caused by hepatocellular carcinoma accounted for 89.4% of the patients, whereas the rate of bleeding from esophageal varices was 4.3%. Variables significantly associated with the duration of survival were Okuda's clinical stage, alpha‐fetoprotein, eradication of esophageal varices by sclerotherapy, and treatment of hepatocellular carcinoma, as determined in a univariate analysis. Multivariate analysis showed that eradication of esophageal varices by sclerotherapy, Okuda's clinical stage, and age were independent factors which significantly influenced survival time. We propose that complete eradication of esophageal varices and close follow‐up using endoscopy may lead to a reduction in bleeding from esophageal varices, and hence may reduce mortality rates related to this bleed

ISSN:0022-4790    

DOI:10.1002/jso.2930590210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractWith the purpose of studying changes in the expression of glycoconjugate structures in cholangiocarcinoma and the nonneoplastic epithelium of stone‐bearing intraheptic bile ducts, a panel of 12 biotinylated lectins were used on formalin‐fixed, paraffin‐embedded tissue sections from 13 patients who had undergone surgical resection of cholangiocarcinoma and on nonneoplastic stone‐bearing intrahepatic bile ducts from 10 patients. Of the 13 patients with cholangiocarcinoma 10 had hepatolithiasis and 3 did not.Among the 12 lectins, only wheat germ agglutinin (WGA) stained the cholangiocarcinoma and nonneoplastic epithelium of the stone‐bearing intrahepatic bile duct. all nonneoplastic epithelia of stone‐bearing intrahepatic bile ducts were stained heavily and homogenously by WGA, the GlcNAC‐specific lectin. The high columnar epithelium of both intramural and extramural glands was stained in the supranuclear region, while the low columnar epithelium of serous acini was stained in the whole cytoplasm. In the well‐differentiated cholangiocarcinoma, the WGA weakly stained the neoplastic cells in the supranuclear region, while it stained the luminal cytoplasmic membrane heavily. In the poorly‐differentiated chollangiocarcinoma, about 50% of cancer cells were stained with WGA. The carcinoma was moderately stained in the cytoplasm. Less reactivity and a lower percentage of cells stained with lectin were found in cholangiocarcinomas when compared to nonneoplastic epithelial. This led us to conclude that there is a dramatic decrease in lectin‐binding carbohydrate structures associated with cholangioca

ISSN:0022-4790    

DOI:10.1002/jso.2930590211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY