摘要:

AbstractEleven unresectable hepatoma patients and three metastatic tumor patients with colonic cancer underwent ligation and/or catheterization of the hepatic artery of the main tumor‐bearing zone. Mitomycin C (liquid or microcapsulated) or Adriamycin were administered via the catheter intermittently or continuously with a portable pump device. In follow‐up study the tumor size was frequently visualized by arteriography via the cannula. Some tumors became smaller with calcification. The levels of α‐Fetopro‐tein of CEA in some cases dropped remarkably and stayed low for a fairly long period. There was no immediate postoperative death. Six of 11 unresectable hepatoma patients survived longer than 8 months with a maximum survival of 17.5 months. Two of three metastatic patients have survived more than 11 months at this writing. This method seems effective for prolongation of patient

ISSN:0022-4790    

DOI:10.1002/jso.2930230402

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractTwenty‐one patients with metastatic germ cell tumors achieved only partial clinical tumor regression following chemotherapy, and underwent surgical biopsy or resection of the residual tumor deposits. Sixteen (76%) are at present clinically disease‐free after a median 30+ months (range 17–50 months) from the time of surgery, and five (24%) died after 9–29 months. Adverse prognostic signs were the finding of persistent cancer at histopathological examination of the resected tumor masses, and the presence of elevated serum tumor markers at the time of surgery. Postchemotherapy surgery in this setting provides tissue for the prognostically important histopathological examination on which a decision regarding further chemotherapy may be based. In addition, it provides tumor bulk reduction in the cases of differentiated teratoma and persistent

ISSN:0022-4790    

DOI:10.1002/jso.2930230403

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractSera of 8 stage II melanoma patients undergoing surgical adjunctive immunotherapy with bacille Calmette Guérin (BCG) plus melanoma cell vaccine (MCV) were assayed for humoral response by the complementdependent antibody cytotoxicity (CDAC) assay and by the microcomplement fixation (MCF) test. The patients developed high levels of cytotoxic (CTX) and complement‐fixing (CF) antibodies to the UCLA‐SO‐M14 (M14) cells, one of the three melanoma cell lines in the MCV. Significant rises in CTX and CF antibodies occurred one month post‐immunotherapy. While the level of CTX antibodies was maintained for 11 months thereafter, the titer of CF antibodies was sustained for seven months, then gradually declined. When the sera were absorbed with lymphoblastoid (ML14) cells which are autologous to the M14 cells, two residual peaks of CTX antibodies, one and four months postimmunotherapy and two peaks of CF antibodies, one and seven months postimmunotherapy, emerged. Two sera that exhibited high levels of CTX and CF antibodies one month postimmunotherapy were absorbed with ML 14 cells and human fetal brain tissue. The reactivity of one serum in both the CDAC and MCF assays was abolished, whereas the reactivity of the other serum was not significantly diminished in either assay. These data indicate that the stage II post‐surgical melanoma patients developed a humoral immune response to at least two distinct tumor antigens on the membrane of the M14 cells. One of these antigens appeared to be of fetal origin (OFA). the other M14‐associated (TAA). Both antigens, OFA and TAA, were involved in complement‐dependent antibody cytotoxic and complement fixation reac

ISSN:0022-4790    

DOI:10.1002/jso.2930230404

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractMice with intravesical urothelial tumors (MBT‐2) were challenged with E coli inoculated intravesically. Adherence of bacteria measured at 15 min or persistent infection at 24 h was significantly greater in the tumorbearing bladders than in normal non‐tumor‐bearing mice. The tumorbearing portion of the bladder contained significantly more bacteria than the non‐tumor‐bearin

ISSN:0022-4790    

DOI:10.1002/jso.2930230405

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractA retrospective study of 177 patients attending Tata Memorial Hospital over a period of 40 years from 1942 through 1981 is presented. These patients who had “primary lesions” in the head and neck region, breast, esophagus, lung, and elsewhere as carcinoma or sarcoma developed “second primary” at different sites, after the treatment for the primary lesion after a variable period over years—as “metachronous lesions” (139 patients). Another group of patients presented with “double primary” at initial clinical examination and investigations, and these were “synchronous” lesions (38 patients). The analysis brings out the relationship of these lesions in both groups to each other with reference to habits in Indian population, viz, pan chewing, tobacco smoking, and alcohol consumption and time interval and histological variations among these lesions. An interesting relationship has been observed in certain aerodigestive tract primary lesions developing second cancer due to continued effect of “carcinogens,” as habits are hard to die even after developing cancer. Analysis also brings out an interesting observation of involvement of “physiologically and anatomically” related organs developing second cancer at an interval or concurrently. A solitary pulmonary nodule or an opacity in a patient with extrathoracic cancer should not be considered as “metastatic” unless proved otherwise; metachronous lesions need to be treated energetically, adequately, efficiently, and aggressively in certain clinical situatio

ISSN:0022-4790    

DOI:10.1002/jso.2930230406

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractAnal gland cancer is often insidious in its presentation with no evidence of an intraluminal mass. It is frequently slow‐growing and often thought to be a perirectal or ischiorectal abscess. Repeated incision and drainage is performed until a biopsy reveals the diagnosis. A very wide resection is then necessary to totally remove the tumo

ISSN:0022-4790    

DOI:10.1002/jso.2930230407

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractInflammatory carcinoma of the breast is rare and lethal. Since the early 1940s, operation except for biopsy has been contraindicated in patients with inflammatory breast cancer. Results with radiotherapy alone and with radiotherapy and chemotherapy are reviewed. Results of treating patients with initial chemotherapy and debulking surgery in patients who respond to chemotherapy are presented. Mastectomy may be safely performed in selected patients with inflammatory breast cancer. Local control will improve quality of life. By removing the breast and residual tumor after chemotherapy and/or radiotherapy, fungation, ulceration, and some of the clinical and psychological problems of uncontrolled local disease may be avoided. Mastectomy should be performed only in patients who responded well to preoperative therapy. Patients who do not respond to chemotherapy should be treated with radiotherapy and should not undergo operation. This approach has not been detrimental to survival or to ultimately achieving local control of the disease.

ISSN:0022-4790    

DOI:10.1002/jso.2930230408

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractIn a material consisting of approximately 6,000 injections of Adriamycin during a 2‐year period, eleven moderate and five severe extravasation injuries have been observed. Even a small leakage of the drug may cause a permanent lesion. The most serious injuries were caused by large doses and on the dorsum of the hand. Plastic surgical operations were successfully performed in the severe cases. An active surgical intervention after primary neutralization of the extravasated Adriamycin is recommende

ISSN:0022-4790    

DOI:10.1002/jso.2930230409

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractFrom 1974–1980, 15 patients with pT2–4bladder carcinoma received adjuvant postoperative radiation therapy (XRT). The extent of initial surgery varied (six radical cystectomy, 5 partial cystectomy, four “total” transurethral resection). The planned XRT was 4,000–5,040 rads in 5–6 weeks to the pelvis (achieved in 14/15 patients) followed by a bladder boost in noncystectomized patients (achieved in 8/9). Survival at two years and five years was 54% (7/13 patients) and 27% (3/11 patients), respectively. Local‐regional disease control (minimum two‐year follow‐up) was achieved in 7/11 (63%). Of seven patients alive at least two years later, small bowel complications (chronic diarrhea, obstruction) occurred in two; these latter patients each had had radical cystectomy. Adjuvant postoperative XRT may be useful in the multimodality management of patients with bladder carcinoma, especially those identified as high risk after pathologic staging and initial surgery. The poor regional control rate and relatively high incidence of complications seen in this and previous studies suggest that improved radiation technique is needed, both to ensure adequate coverage of the volume at risk and to minimize complications. Representative portals are shown to illustra

ISSN:0022-4790    

DOI:10.1002/jso.2930230410

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY

摘要:

AbstractWe reviewed 17 patients with colon carcinoma metastatic to the ovary seen from 1970–1980. This represents 2.5% of the total malignant ovarian neoplasms seen during this time period. In 3/17 patients, exploratory celiotomy was performed without preoperative barium enema, stool for occult blood, or colonoscopy. These patients subsequently were found to have a primary colon carcinoma. Colectomy was performed in 8/17 of our patients without prophylactic oophorectomy. All of these patients subsequently developed metastatic ovarian carcinoma. Long‐term survival in our series was dismal. We recommend (1) a compulsary colon examination to include colonoscopy prior to surgery for ovarian masses, and (2) prophylactic bilateral salphingo‐oophorectomy at the time of colectomy for colon carc

ISSN:0022-4790    

DOI:10.1002/jso.2930230411

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1983

数据来源: WILEY