摘要:

AbstractBenign non‐parasitic cysts of the spleen are very uncommon, with a total of 651 cases having been described in the literature to date. Because of their uncommon nature, and the fact that their symtoms may be vague, a high index of suspicion is necessary if they are to be diagnosed. The therapy of choice is surgical excision by splenectomy and the accompanying cystectomy. The prognosis following such therapy is excellen

ISSN:0022-4790    

DOI:10.1002/jso.2930100502

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractOne hundred forty‐four Wistar‐Furth rats in 12 therapeutic groups have been studied in a long‐term comparison of the effectiveness of nonspecific immunotherapy with MER (methanol extraction residue) vs active‐specific immunotherapy with neuraminidase‐modified tumor cells. Six months after surgical adjuvant immunotherapy a 100% improvement in survival was achieved with MER immunotherapy compared to untreated control animals. In addition, the use of MER enhanced the value of active‐specific immunotherapy where both modalities were combined in sequence. The predicted value of MER‐BCG (Bacillus Calmette‐Guerin) for the immunotherapy of solid tumors was borne out by these results suggesting that present ongoing clinical trials of MER as adjuvant therapy for large bowel cancer should prove to be successful if properly controlled. The pattern of survival in these experiments suggests that surgical adjuvant immunotherapy is cytostatic rather than cytocidal, and implies the need for long‐term, repea

ISSN:0022-4790    

DOI:10.1002/jso.2930100503

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA case of locally recurrent and metastatic uterine hemangiopericytoma successfully treated with surgery, radiotherapy and chemotherapy is presented. The patient is alive without evidence of detectable tumor, 13 years after the initial diagnosis. Review of the literature revealed 64 reported cases of uterine hemangiopericytoma. The clinical features are not sufficiently characteristic to enable the diagnosis to be made preoperatively. However, with the help of histological and ultrastructural studies a definite diagnosis of hemangiopericy toma can be made. The primary treatment is radical surgery which usually involves total hysterectomy and bilateral salpingo‐oophorectomy. The prognosis of uterine hemangiopericy toma is better than that of other sites. However, long follow‐up of these patients is necessary because of the tendency to local and distant recurrence many years after the initial treatment. The recurrent tumor should be treated aggressively with surgery, radiotherapy, and chemotherapy as long‐term survival is not un

ISSN:0022-4790    

DOI:10.1002/jso.2930100504

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractThirteen cases of leiomyosarcomas of the extremities are reported. Most of the cases were operated on without information concerning benignancy or malignancy. Plain radiographs showed amorphous calcification in two cases. Three cases had angiographic study and all revealed malignant neovascularity. In no literature that we reviewed was angiography mentioned in the cases of leiomyosarcomas of the extremities. Venography alone has been done in many reported cases. The leiomyosarcoma of the extremities looks often benign but is notorious for local recurrences and distant metastases.

ISSN:0022-4790    

DOI:10.1002/jso.2930100505

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractKlinefelter syndrome increases the risk of developing breast cancer to approximately 1/5 that of women and 20 times that of normal men. A case report and the patient's response to hormone manipulation for metastatic disease is described.

ISSN:0022-4790    

DOI:10.1002/jso.2930100506

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractThe effectiveness of MFC (mitomycin C, 5‐fluorouracil and cytosine arabinoside) therapy for non‐resectable cancers and cancers recurring after surgery was investigated in 60 patients with solid cancers aged 26 to 69 years. Treatment was effective in 28 patients (47%) including seven (12%) who showed a very good response. Side effects included anorexia, vomiting, melena, anemia, decreased leukocyte and platelet counts, and impaired renal function. In particular, hemorrhage of the digestive tract should be watched carefully during MFC therapy. MFC therapy is suitable for solid tumors of the breast and digestive organs, especially with metastases to the lymph nodes. Response to treatment is generally seen after 6–10 doses. If there is no response at this time, treatment should be changed. In cases where induction of remission is successful, maintenance therapy should be continued keeping the frequency of administration to a minimum. Remission is readily induced with MFC therapy, but because of the problems of hemorrhage of the digestive tract, and bone marrow suppression, its use for out patient treatment is not considered safe. Therefore, alternative treatment should be given for long term maintenance of remission. FAMT (5‐fluorouracil, cyclophosphamide‐endoxan, mitomycin C, chromomycin A3‐toyomycin) therapy is considered safe and suitable for maintenance therapy in outpatients. Three cases in which MFC therapy was very effective are described to illustrate the treatm

ISSN:0022-4790    

DOI:10.1002/jso.2930100507

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractFive cases of malignant fibrous histiocytoma are presented and the relevant literature is reviewed. All the patients had locally extensive tumor or eventual recurrent or metastatic disease. Determining malignancy by histologic criteria is difficult. Therefore, histologic, gross, and clinical behavior of the tumor is important. Though the role of radiation therapy and chemotherapy is not yet established, it appears that at least wide “cancer resection,” if possible, is the treatment of choice. The unusually high incidence of nonresectable, recurrent, or metastatic disease in retroperitoneal histiocytomas raises the question as to whether all three modalities of therapy should be used in the treatment of tumors at this particular s

ISSN:0022-4790    

DOI:10.1002/jso.2930100508

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractChloroma cells, which were shown to contain the X and Y chromosomes, were used to induce Shay chloroleukemia (SCL) in female recipients. Karyotype analyses of leukemic myeloblasts which appeared in the peripheral blood of the female recipients during blast crisis demonstrated invariably the presence of the X and Y chromosomes. These results directly demonstrate that transmission of SCL is the result of donor cell colonization and therefore SCL can be considered a true transplantable leukemia. Reports by other workers of viral association with this dissease are discussed in light of our results.

ISSN:0022-4790    

DOI:10.1002/jso.2930100509

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractBacillus Calmette‐Guérin (BCG) was administered in various doses by four different routes to C3H/HeJ mice bearing well‐established syngeneic MC‐42 fibrosarcomas. Injections of BCG into established primary tumors decreased survival of tumor‐bearing mice as compared to saline‐injected controls. Of the three dosage groups, high‐dose (108viable organisms) intralesional BCG was most detrimental. The injection of low‐dose BCG (104organisms) into established tumors or subcutaneously at a distant site also shortened host survival times. Other subcutaneous injections and injections of BCG into the peritoneal or pleural cavities had no significant effect on survival, regardless of dosage. The dose‐dependent effects of BCG immunotherapy which may prolong or shorten surviv

ISSN:0022-4790    

DOI:10.1002/jso.2930100510

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractAntibody against Epstein Barr Viral capsid (EBV‐VCA) was measured in 65 patients with primary head and neck cancer referred for radical radiotherapy. Sixty‐three percent had locally advanced cancer and 37% had early disease. Forty‐eight percent had detectable antibody in their sera. Thirty‐three percent had elevated titers (above 1:20 dilution). Only 19% of cases with early cancer had increased titers. Almost 50% of those with locally advanced cancer or recurrence following treatment had titers above 1:20. A rise in titer within six months following radiotherapy was associated with a significant incidence of recurrence. There was no correlation between delayed hypersensitivity skin reaction to 2–4 dinitrochlorobenzene (DNCB) and titer values. EBV‐VCA may be an additional parameter which can be used to determine host defenses in patients with m

ISSN:0022-4790    

DOI:10.1002/jso.2930100511

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY