摘要:

AbstractThe efficacy of killing small cell lung cancer (SCLC) cells at the G1, S, and G2‐M phase of the cell‐cycle by a new111In‐bleomycin complex (111In‐BLMC) was investigated. SCLC cells (N417, H526, H209) were synchronized by double thymidine block and assessed by DNA content with flow cytometry, and the period for the maximal accumulation of cells in S, G1, or G2‐M phase was determined. Cells in different cell cycle phases were exposed to 0.9% NaCl, BLM, or111In‐BLMC for 1 hour and observed for colony formation. The survival of H526 cells treated with111In‐BLMC was 71% (for enriched S phase), 46% (G1), and 31% (G2‐M). For N417 cells, it was 25% (S), 20% (G1), and 8% (G2‐M) for111In‐BLMC and 18%% (S), 33% (G1), and 10% (G2‐M) for BLM. These results indicated that SCLC cells in G2‐M were most sensitive and those in S phase were least sensitive to111In‐BLMC; cells in G1phase were t

ISSN:0022-4790    

DOI:10.1002/jso.2930400203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractThe influence of splenectomy upon the growth of B16‐F10 malignant melanoma and changes in interferon‐synthesizing ability in mice were studied. Surgical stress alone temporarily diminished the ability of mice to respond to interferon induction by poly rIrC. Two weeks following the surgery, mock‐splenectomized mice fully regained their interferon synthesis ability. However, this was not true in the case of splenectomized mice. They remained refractory to interferon induction. The removal of the spleen had no obvious effect on the rate of pulmonary metastasis in mice injected with B16‐F10 malignant melanoma in relation to the mock‐splenectomized or control mice. Mice that were splenectomized and inoculated with B16‐F10 melanoma also remained refractory to interfero

ISSN:0022-4790    

DOI:10.1002/jso.2930400204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractLeukocyte alkaline phosphatase (LAP) scores in peripheral blood and plasma carcinoembryonic antigen (CEA) levels were determined in 208 breast cancer patients with nonmetastatic disease. Patients were followed until clinical manifestations of metastases appeared. Then the LAP score and CEA level were analyzed in relation to the clinical appearance of metastases.Of the 208 patients studied, 58 developed metastases during the follow‐up period. The LAP scores and CEA levels of this group of patients were compared to a control group of 60 breast cancer patients who did not develop metastases. Of the two markers, LAP score seems to be considerably more useful in detecting metastatic diseas

ISSN:0022-4790    

DOI:10.1002/jso.2930400205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractEmergency one‐stage surgery for acute, complicated, left‐sided colonic cancer can be performed because of intraoperative antegrade irrigation of the large intestine. This procedure was performed in 17 patients: 15 patients with an obstructive, left‐sided cancer and two patients with a perforated carcinoma. The age distribution ranged between 57 and 92 years. There were two postoperative septic complications: a small wound abscess and a partial abdominal wall dehiscence. One patient died because of massive upper gastrointestinal bleeding. This method permits the creation of a primary anastomosis in the left colon, obviating the necessity of a coeco‐ or colostomy, preternatural anus, or an extensive right‐sided hemicolectomy. Several surgical interventions are avoided, resulting in a decrease of mortality, morbidity, duration of hospital stay, and costs. Moreover, intraoperative irrigation could be an attractive alternative for the usual preoperative mechanical bowel preparation, which is especially burdensome in elderly

ISSN:0022-4790    

DOI:10.1002/jso.2930400206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractVaccinia virus (VV) was used to infect and lyse the Balb/c colon tumor line C‐C36 to prepare oncolysate (VCO) with augmented immunogenicity. Mice treated with VCO and challenged with C‐C36 were significantly protected against tumor growth as compared to untreated controls (P<0.001) and mice treated with CO (P<0.01). Moreover, protection induced by VCO was specific when growth inhibition of C‐C36 was compared to that of meth‐A (P = 0.027). Splenocytes from mice stimulated with VCO in vitro showed greater proliferation than splenocytes stimulated with CO alone or VV alone, suggesting induction of a unique VCO component. Additional evidence for a specific response was suggested by the observation that splenocytes stimulated with VCO in vitro demonstrated augmented cytolysis of C‐C36 but did not show cytolytic activity against unrelated target cells. However, augmented cytolysis of the natural killer (NK)‐sensitive YAC‐1 by VCO‐stimulated splenocytes was also observed. These results suggest that in vivo resistance to tumor challenge induced by VCO treatment may result from stimulation of both specific and nonspecific

ISSN:0022-4790    

DOI:10.1002/jso.2930400207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractA retrospective review of 832 patients with squamous cell cancer of the head and neck between 1961 and 1985 was carried out to determine the incidence of multiple primary cancers (MPC) at the time of autopsy and the number who died of the second cancer. The overall risk of developing a second MPC of the head and neck, lung, or esophagus from treatment of first head and neck cancer to time of autopsy was 4.04% per year.

ISSN:0022-4790    

DOI:10.1002/jso.2930400208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractIn patients with a malignant primary disease the risk of thromboembolic complication is demonstrably increased. This is undoubtedly attributable to a whole range of factors (multifactorial etiology) which are highlighted in the present synoptic study. In addition to local influences from the tumor, a particular role appears to be played by an increased aggregation of thrombocytes, various tumor cell products, polyglobulism, hypercalcemia, increased release of thrombocinase, microthrombotic embolization, and a decrease in antithrombin III.

ISSN:0022-4790    

DOI:10.1002/jso.2930400209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractSputum cytologic examination is still an important method for diagnosing lung cancer, and it is simple to perform. The present report is an analysis of 161 cases of primary lung cancer proved by thoracotomy. A detection rate of 73.3% in sputum and 84.5% in combination with other cytologic methods have been obtained. Cytotyping accuracy as compared with histologic classification in 105 cases was 79.0%. The importance of examining more than three sputum samples from a patient with suspected lung cancer is stressed.

ISSN:0022-4790    

DOI:10.1002/jso.2930400210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractIt is difficult, time‐consuming, and expensive to evaluate the therapeutic efficacy of regional chemotherapy of metastatic liver disease by means of imaging procedures. Therefore it was the aim of this study to find out whether serial carcinoembryonic antigen (CEA) determinations yield reliable data on the therapeutic progress and the individual prognosis of these patients. Since there exists no generally accepted modality to assess CEA curves of patients receiving chemotherapy, we developed our own criterion and tested it in a group of 35 patients. For each patient an individual reference level (CEA‐x̄) was fixed which was obtained as the arithmetical mean of serial CEA values taken during the first three courses of chemotherapy (reference time). On the basis of CEA‐x̄ the marker curves of the 35 patients could be divided into two groups. After the reference time the CEA values of group 1 (12 patients) never decreased below CEA‐x̄. Survival of these patients was significantly (P= 0.00001) shorter than that of the 23 patients (group 2) who showed a decrease in their CEA curves below CEA‐x̄ after the reference time. Beyond this it could be observed that the improvement in survival was significantly greater in those patients who showed a CEA decrease below CEA‐x̄ for a prolonged period (3 months). This difference in prognosis is not an artefact due to different pretherapeutic conditions but is a sign of different responses to therapy. The decrease in CEA values below the individual reference level (CEA‐x̄) is a certain sign of the efficacy of the chosen chemotherapy. A continuous rise of the CEA curve above CEA‐x̄ signifies an ineffective intrahepatic chemotherapy or extrahepatic tumor manifestation. In this case an intensive diagnostic workup of the patient and possibly a modification of the

ISSN:0022-4790    

DOI:10.1002/jso.2930400211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY

摘要:

AbstractLocalization of lymphocyte subsets and macrophages in the mesocolic lymph node of the colorectal cancer and their distribution among the paracolic, intermediate, and main nodes were studied quantitatively by means of immunohistochemical staining with monoclonal antibodies. In all of the three lymph node groups, in the paracortex, helper/inducer T cells were more numerous than suppressor/ cytotoxic T cells. The number of whole T cells in the paracortex diminished with increasing proximity to the primary tumor. In the three lymph node groups, no significant difference was found regarding the ratio of the cell number among suppressor/ cytotoxic T cells, natural killer cells, and macrophages. Lymphocytes in the paracortex of lymph node had a positive correlation to lymphocytes in the peritumoral stroma and intratumoral fields. These data neither suggest the presence of a powerful immunological reaction in the mesocolic lymph node nor support the concept of conservation of uninvolved regional lymph nodes in the surgery of the colorectal cancer.

ISSN:0022-4790    

DOI:10.1002/jso.2930400212

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1989

数据来源: WILEY