摘要:

AbstractOf the various methods used for the management of the remaining pancreas in 70 patients who had pancreatoduodenectomy for cancer, pancreatojejunostomy (P/J) was associated with the lowest morbidity and closure of the remnant with the highest. End‐to‐end and end‐to‐side P/J were equally satisfactory, the use of stents, however, doubled the morbidity. P/J was particularly safe in the presence of a dilated pancreatic duct. Closure of the remnant caused a very high morbidity regardless if the pancreas was closed with sutures or staples. Despite their difference in morbidity, P/J and closure had the same mortality and approximately the same impact on pancreatic function, exocrine as well as endocrine. The study indicated that although closure of the remnant, as it is practiced today, gives results inferior to those obtained with P/J, with some modification it might offer a simple alternative to P/J in the

ISSN:0022-4790    

DOI:10.1002/jso.2930180102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractThe use of a selected group of biological markers in breast cancer patients who are disease free but at risk of relapse after mastectomy has potential for detecting recurrent tumor before there is clinical evidence. In this preliminary study, multiple materials were serially analyzed in the body fluids of patients without overt tumor but receiving adjuvant chemotherapy because of positive axillary nodes at surgery. The total frequency of elevated levels was determined and compared for those patients who remained disease free, for those who subsequently relapsed, and for a third group of patients with proven metastases. Frequency of elevation was directly proportional to increasing disease. Although differences in the relative frequency of individual materials was observed, the same trends with increasing tumor burden were found. The results suggest that the serial measurement of biological markers has potential for indicating the presence of occult disease. A nucleus of biological markers to be considered should include carcinoembryonic antigen, urinary hydroxyprolineheatinine ratio for bone lesions, and γ‐glutamyltranspeptidase for liver involveme

ISSN:0022-4790    

DOI:10.1002/jso.2930180103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractThe metastatic capacity of rat mammary tumors induced with N‐nitrosomethyl urea was tested in BUF/N inbred female rats by successive transplantation. After the first and second passage, tumor cells appeared diffusely distributed throughout the bone marrow and spleen, confirming results reported by others; no other metastases were observed. After six successive transplantations, large, well‐defined tumor nodules were observed in the liver, spleen, lung, and the peritoneal surface of the intestines in 40% of the injected animals. The morphology of the primary and metastatic tumors was compared by light microscopy. The tumors appeared to be adenocarcinomas with differing degrees of differentiation. No morphlogical differences could be observed between the primary and the metastatic tum

ISSN:0022-4790    

DOI:10.1002/jso.2930180104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractTwenty‐one patients undergoing gastrectomy for adenocarcinoma of the stomach died during the first two postoperative weeks and were subjected to autopsy. They all had “curative” resections for lesions confined to the stomach and the regional lymph nodes. Autopsy revealed distant metastasis in ten of 13 patients who had (TNM) stage III disease at the time of surgery. There was no residual disease in patients with stage I and II lesions (P<0.01). The study suggests that, in most cases, stage III gastric adenocarcinomas have already spread beyond the confines of gastrectomy at the time of oper

ISSN:0022-4790    

DOI:10.1002/jso.2930180105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractWe examined, by light and electron microscopy, three cases of malignant lentigo, one of which was in the vertical growth phase. The purpose of our work was to compare the diverse patterns between superficial spreading melanoma and malignant lentigo. The observations suggest the following major findings: 1) the cells of malignant lentigo differ from normal melanocytes, and in the same specimen they differ from one another; 2) in malignant lentigo, melanosomes at stage II‐IV are visible; and 3) in spreading melanoma, the melanosomes do not attain complete maturation. These morphological features explain the different behaviour of these two types of tumor

ISSN:0022-4790    

DOI:10.1002/jso.2930180106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractThe end results of therapy of 346 patients with lung tumors, treated with surgery alone, are compared, depending on the type of general anesthetic agent used. Anesthesia was induced with ether in 220 patients, halothane in 103, and neuroleptanalgesia in 23 cases. All the anesthetic agents were administered in a mixture with nitrous oxide. The basic characteristics of patients, who were divided on the basis of anesthetic agent, were identical. The results show that type of anesthesia during surgical treatment for lung tumor has an effect on the end results of therapy, and the best prognosis is ensured when halothane is used. Further analysis established that the end results of surgery with halothane anesthesia are improved, when partial resection rather than radical pneumonectomy is performed, at stage 2 of malignant disease and when metastases into regional lymph nodes are absent. Such improvement may be explained by stimulation of the hypothalamo‐pituitary‐adrenal system as well as a relatively lower degree of immunosuppression and development of conditions more adverse for implantation of circulating tumor cells than in the case of ether or neuroleptanalgetic anesthe

ISSN:0022-4790    

DOI:10.1002/jso.2930180107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractA study of 257 gastric cancer patients treated with gastrectomy and followed to their death showed that (a) the incidence of local recurrence in the field of gastrectomy was 25%; (b) from the three types of gastrectomy used, extended total gastrectomy resulted in the lowest incidence of recurrence, followed by subtotal and total; (c) recurrences were more common in patients with TNM stages I, II, and III tumors where extended total gastrectomy was proven superior (p<0.05); (d) early stage tumors tended to recur in the gastric remnant and the esophagus; (e) narrow surgical margins and margins involved by disease predisposed to recurrence; (f)not every patient with histologically invaded margins developed recurrence; (g) the risk of recurrence did not decrease with time; (h) the longer the disease‐free interval the better the prognosis; (i) the more advanced the original lesion the longer the disease‐free interval; (j) of all patients with recurrence only 19% had resectable lesions on reexploration; (k) the longer the disease‐free interval the higher the resectability rate; (l) the median interval from recurrence to death was 2 months; (m) the same interval of those undergoing resection was 18 months. Patients with early‐stage tumors treated with gastrectomy should be followed closely for local recurrence and should recurrence develop they should be reexplored if there is no evidence of met

ISSN:0022-4790    

DOI:10.1002/jso.2930180108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractIt is well established that approximately 60% of female breast cancers contain estrogen receptors (ER+). The hormonal receptor status of male breast cancers remains relatively unknown. Tumor tissue from 14 patients has been reviewed at the University of Oregon Health Sciences Center. Specimens of all 14 patients were ER+ with a range of 5.5 to 374 fmol/mg protein. Eight of 12 patients had tumors which also contained progesterone receptors (PR+) with a range of 42 to 1852 fmol/mg protein.Nine patients were treated by modified radical mastectomy, two by radical mastectomy, one by simple mastectomy, and two by biopsies only. Twelve patients remain free of disease with a mean follow‐up of less than 2 years. The two patients who developed metastases both responded to endocrine ablation by orchiectorny and subsequent adrenalectomy.These data suggest that male breast cancer is highly endocrine sensitive and that endocrine ablation can play an integral part in those men unfortunate enough to develop disseminated diseas

ISSN:0022-4790    

DOI:10.1002/jso.2930180109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractA case of locally invasive malignant thymoma is presented. This 8‐month‐old child presented with respiratory distress and superior vena cava syndrome. Histology revealed malignant lymphocytic thymoma infiltrating the great vessels, pericardium, and regional lymph node. He was successfully treated with surgical removal, radiotherapy, and aggressive chemotherapy. We believe he is the youngest child with thymoma reported in medical literat

ISSN:0022-4790    

DOI:10.1002/jso.2930180110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY

摘要:

AbstractWe have applied an in vitro colony‐forming assay system to the study of primary urothelial explants obtained transurethrally by bladder barbotage and tumor biopsy from 91 patients. Urothelial cells obtained by bladder barbotage from patients with bladder cancer and from a “control” group of individuals exhibit differential capacity to clone in agar. Of samples from bladder cancer patients, 88% formed colonies, whereas only 27% of these from a “control” group did so. Of samples from a “suspicious” patient group, 70% formed colonies. In vitro drug sensitivity studies of cells obtained by biopsy of solid tumors demonstrate a spectrum of drug sensitivity to cyt

ISSN:0022-4790    

DOI:10.1002/jso.2930180111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1981

数据来源: WILEY