摘要:

AbstractA case report of a 56‐year‐old man with the characteristic clinical and histologic features of multiple neurofibromatosis is presented. This patient was also diagnosed as having a malignant fibrous histiocytoma involving the right thigh with metastasis to the lung. A definite association between Von Reckling‐hausen's disease and various sarcomas (most commonly neurofibrosarcomas) of the peripheral nerves and the somatic soft tissues is well‐known. This is apparently the first report in the literature of a malignant fibrous histiocytoma arising in a patient with multiple neurofibromatosis. The phenomenon of sarcomatous change in Von Recklinghausen's disease and the clinical and pathologic features of malignant fibrous histiocytoma are also di

ISSN:0022-4790    

DOI:10.1002/jso.2930120202

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractZinc in plasma and whole blood from 13 patients with squamous cell carcinoma of the head and neck was significantly decreased, and the copper:zinc ratio in the plasma was significantly higher than in healthy controls.The plasma zinc was significantly lower in patients who did not respond to therapy and who died within 12 months than in those who responded to therapy and had a remission within 12–15 months. In patients responding to therapy and alive after 12–15 months, zinc in the plasma and whole blood and the copper:zinc ratio became normal.These results suggest a potential screening and predicting value of zinc in the plasma and whole blood and the copper:zinc ratio in squamous cell carcinoma of the head and n

ISSN:0022-4790    

DOI:10.1002/jso.2930120203

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractSquamous cell carcinoma of the skin complicated by hypercalcemia is very rare. This report is of a patient with long‐term exposure to medicinal oral arsenic who developed an extensive squamous cell carcinoma complicated by hypercalcemi

ISSN:0022-4790    

DOI:10.1002/jso.2930120204

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe case history of a 10‐year‐old black girl with gliomatosis peritonei, Grade 0, is presented. The primary tumour was resected and a “second look” operation carried out 3 months later. The glial implants demonstrated distinct circumferential and intra glial fibrosis (resolution). Because the peritoneal implants had undergone resolution, further therapy became unnecessary.We believe gliomatosis peritonei fully justifies a second laparotomy in order to be able to accurately grade the implants. The grade of the peritoneal implants influences the prognosis and therefore determines the type of therapy to be ins

ISSN:0022-4790    

DOI:10.1002/jso.2930120205

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractRadioimmunoassay for serum carcinoembryonic antigen (CEA) was performed in 49 colonic cancer patients. The test results were positive in 42 patients (85.7%) in whom tumor was present at the time of assay. Preoperatively, CEA level suggested the extent and the prognosis of the disease. Strongly positive CEA test results in such patients correlated with metastatic tumors and poor prognosis. Postoperatively, a positive result for serum CEA indicated presence of residual tumor, while negative results did not exclude residual tumor. Periodic CEA determination in the patients who have undergone resection of colonic cancer may detect tumor recurrence that is at a treatable stage. The data show that patients in whom the immediate postoperative CEA concentration returns to normal have a much lower incidence of recurrent cancer of the colon than patients whose CEA level remains elevated.

ISSN:0022-4790    

DOI:10.1002/jso.2930120206

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA 59‐year‐old black woman presented with an ill‐defined plaque on her nose. This appeared clinically suggestive of a sclerosing type of basal cell epithelioma (BCE). Microscopic sections demonstrated this diagnosis. Multiple excisions employing the microscopically controlled technique of Mohs traced the tumor deep into the nasal cartilage before histologic sections were free of tumor cells. This type of BCE deserves well planned therapy because of its destructive pote

ISSN:0022-4790    

DOI:10.1002/jso.2930120207

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA retrospective study of 1, 178 females suffering from cancer of the breast and treated by radical mastectomy is presented. All operations were performed by essentially one group of four senior surgeons, each either trained or connected with Memorial Sloan Kettering Hospital in New York and spent practically all of his professional career in the treatment of cancer. The same techniques of surgery were practiced. The same principles of the overall treatment were utilized; namely, if there were no metastases to lymph nodes detected on histologic studies, no radiation therapy was given. If metastases were present in the axillary lymph nodes, each of the patients received postoperative radiation therapy. None received either chemotherapy nor immunotherapy, as primary treatment. The study includes all patients treated between 1930 and 1965 and complete follow‐up data were obtained in 94.6% of all patients. Five hundred and ninety‐six patients were classified histologically as Stage I (50.6%), 291 as Stage II (24.7%), 74 as Stage III (6.3%), and 217 patients (18.4%) were undetermined. The total number of patients who developed a second primary cancer in the remaining breast was 91 (7.7%), and only 51 patients (4.3%) developed local recurrences in the chest wall or axilla. The mean age of the patients was 51.9 years. The absolute 5‐year survival of all patients was 64% and the 10‐year survival equaled 54.6%. The 9.4% mortality between the 5‐ and 10‐year survival emphasizes that the 10‐year survival figures are a more accurate index of survival. The larger the tumor, usually the poorer the prognosis, except where the tumor was 8 cm or larger where the prognosis was rather good. This indicates some biolog

ISSN:0022-4790    

DOI:10.1002/jso.2930120208

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractSerum immunoglobulins were determined in 120 women with breast cancer. A strong association between age at tumor diagnosis and serum IgA levels was noted. Relative hypoglobulinemia of IgA was associated with appearance of tumors early in life, and was more frequent among women with family history of breast cancer and among those with poor prognosis. A strong association between levels of serum IgG and parity was noted. Parous women and/or those who had good prognosis had higher levels of serum IgG, compared to nulliparous women and those with poor prognosis. The observations indicate that serum immunoglobulins may be useful in the identification of women who have a high breast cancer risk and poor prognosis.

ISSN:0022-4790    

DOI:10.1002/jso.2930120209

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractThe effects of elemental diets on selected aspects of the rat colon were studied. Forty young male Sprague‐Dawley rats were divided into 4 diet groups of 10 rats each: Purina Rat Chow (control); Flexical; Precision L‐R; and Vivonex. All diets were fed ad lib to rats housed in pairs in wire‐bottom cages. Two weeks after weight stabilization had been achieved all rats were killed and colon contents were collected for culture and short‐chain fatty acid analysis on the Perkins‐Elsoner 3920 gas chromatograph. Colon fecal butyric/acetic acid ratios of the rats in the 4 groups were: Rat Chow, 2.56; Flexical, 0.28; Precision L‐R, 0.16; and Vivonex, 0.26. Bacterial cultures showed increased coliform and enterococcal species in the rats consuming elem

ISSN:0022-4790    

DOI:10.1002/jso.2930120210

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY

摘要:

AbstractA 13‐year‐old white male had Ewing sarcoma of the right pubic and ischial bones. Initial therapy consisted of 5,400 rads in seven weeks to the right side of the pelvis and 14 intravenous injections of cyclophosphamide (Cytoxan, CTX) at 500 mg/m2; BCNU and Adriamycin maintenance therapy continued for a total of two years. He has now been disease‐free for five years.Three months following the completion of the right pelvic radiotherapy (RT), while on intravenous CTX, severe hematuria appeared, which subsided, but at present he has continuous microscopic hematuria, as well as periodic episodes of gross hematuria.Serial cystocopies initially revealed thickening and hemorrhagic and edematous changes on the right (irradiated) side of the bladder, and recent multiple telangiectatic patches have been demonstrated as a late “healing” phase.This case demonstrates the additive toxicity to the bladder of CTX and RT, illustrating that the hemorrhagic cystitis can be extremely protracted lasting f

ISSN:0022-4790    

DOI:10.1002/jso.2930120211

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1979

数据来源: WILEY