摘要:

We examined a 52-year-old man with bilateral symmetric lesions of the cornea and fundus. The corneal lesions were compatible with granular dystrophy, and the fundus lesions were consistent with cone dystrophy. The simultaneous occurrence of these dystrophies may be uncommon.

ISSN:0030-3755    

DOI:10.1159/000309920

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

In 14 patients undergoing hemodialysis, the intraocular pressure did not change significantly when measured at hourly intervals for 4 h. There was a loss in body weight because of fluid loss; also the Schirmer values decreased significantly at the conclusion of treatment. Blood osmolality decreased markedly in a linear fashion. The fluctuations of intraocular pressure during hemodialysis were likely dependent on the dynamics of dehydration and hypo-osmolality. Regulatory forces stabilized the intraocular pressure to such a degree that statistical significance in these fluctuations was not reached.

ISSN:0030-3755    

DOI:10.1159/000309921

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Transient accommodative paresis and pupillary disturbances are some of the less known and uncommon complications of peripheral retinal laser treatment extending over at least one third of the retinal periphery. They are the result of damage by the laser applications to parasympathetic nerve fibers that lie beneath the coagulated area and innervate the ciliary body and iris sphincter. Six myopic patients who suffered from these complications following peripheral laser treatment for retinal tears are presented. A mechanism of direct damage to ciliary muscle fibers during photocoagulation is proposed.

ISSN:0030-3755    

DOI:10.1159/000309922

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A population-based study found an overall incidence rate of symptomatic retinal vein occulusion (RVO) in a 4-year period to be 2.14 per 1,000 in the 40 years and over age group. When cases found among glaucoma clinic patients were separated from the remainder of the population there was marked difference in the incidence rate of RVO in the same time period (1.85 and 17.3 per 1,000, respectively). The rate of RVO increased significantly (p < 0.001) with age in the general population from 0.93 per 1,000 among persons under 64 years of age to 5.36 per 1,000 among persons over 65. The increase in the rate of RVO by age was less dramatic in the glaucoma clinic population. The two populations also differed in the frequency of the occlusion type: the ratio of the rate of branch vein occlusion to central vein occlusion was 3.2:1 in the general population, but equally distributed in the glaucoma clinic population. Persons with increased intraocular pressure and/or glaucoma were found to have a higher prevalence of RVO than persons with no history of elevated intraocular pressure.

ISSN:0030-3755    

DOI:10.1159/000309923

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Response to treatment was evaluated prospectively in 58 patients with Graves’ ophthalmopathy. Prednisone, administered to 44 patients, resulted in a favourable response in 29 patients (66%): excellent in 3, good in 10 and fair in 16 subjects; 15 patients (34%) did not respond. Orbital irradiation was administered to 39 patients of whom all except 4 had been treated previously with steroids. Six months later, 25 patients (64%) had responded favourably (excellent in 0, good in 9 and fair in 16 subjects) and 14 patients had not responded (36%). A favourable response to prednisone or irradiation was reflected in a general shift to lower grades in each of the classes 2–6 of the NOSPECS system. Responders were not different from non-responders with regard to age, sex, NOSPECS classification, ophthalmopathy index, interval between the onset of eye disease (or of thyroid disease if present) and the start of treatment, or the presence of thyroid disease. In conclusion, (1) the ratio of responders to non-responders is 2:1 for both prednisone treatment and orbital irradiation in Graves’ ophthalmopathy, (2) the response is seen in all classes of the NOSPECS system, and (3) the response is not dependent on age, sex, severity or duration of eye disease, or the presence of thyroid disease.

ISSN:0030-3755    

DOI:10.1159/000309924

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

For elucidating the nonvisual eye position control system, we studied the accuracy of saccades toward the remembered position (memory-guided saccades) in a patient with ocular lateropulsion having tonic bias of the eye position. Although the saccadic dysmetria caused by ocular lateropulsion was recorded during memory-guided saccades in the same manner as visually guided saccades, the eyes reached precisely the intended position by corrective saccades. The mean latency of corrective saccades was significantly longer than that of corrective saccades observed for visually guided saccades. This long latency of corrective saccades supports the assumption that feedback information of the eye position is a signal generated by orbital afferents rather than a copy of the motor command.

ISSN:0030-3755    

DOI:10.1159/000309925

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

We evaluated the efficacy and safety of 0.5% levobunolol HC1 (Vistagan®) in 2,041 glaucoma patients at 143 sites in the Federal Republic of Germany. This study was a 3-month, open-label, noncomparative trial of levobunolol administered twice daily. Eighty-five percent of the patients completed the study period with well-controlled intraocular pressure (IOP). Treatment was discontinued in the remaining 15%: 7% for adverse reactions, 1% for lack of drug efficacy, and 7% for reasons unrelated to the study treatment. Efficacy, ocular drug tolerance, and systemic safety were judged as good to very good in approximately 80% of the patients. This large, postapproval study confirms previous findings of several well-controlled clinical trials indicating that levobunolol is an effective drug for the treatment of elevated IOP and is safe and comfortable for most patients

ISSN:0030-3755    

DOI:10.1159/000309926

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

We review 77 patients with perforating ocular wounds due to occupational accidents seen in our hospital over a period of 5 years. Industrial accidents were the most frequent cause (61.04%), followed by agricultural (25.97%) and services trade (12.98%). Seventy-five patients were males (97.40%), with a mean age of 32.88 years. The cornea was statistically the most frequent location (p < 0.001). The nasal quadrants were more frequently affected than the temporal ones (p < 0.001) and the upper quadrants were also more affected than the lower ones, especially in the cornea (p < 0.001). Fifty-two percent had intraocular foreign bodies; industrial accidents were responsible of 65% of these injuries. They were significantly more frequent in summer than in autumn (p < 0.001) and spring (p < 0.001). We discuss the prognosis of these injuries and the circumstances that may influence in their occurrence, stressing the importance of prevention programs.

ISSN:0030-3755    

DOI:10.1159/000309927

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The effect of alpha-human atrial natriuretic peptide (alpha-hANP) on the intraocular pressure (IOP) was studied in normal rabbits. Dose response studies to IOP were performed after intravenous administration of alpha-hANP at 6.25, 12.5, 25.0, 50 and 100 μg/kg to the rabbits. The maximum reduction in IOP was observed to occur with the alpha-hANP 50 μg/kg dose. The time course of the pressure response to alpha-hANP were measured prior to and following intravenous administration of 50 μg/kg of alpha-hANP. The change in IOP and blood pressure showed the same pattern in the simultaneous record. Silver grains of 125I-alpha-hANP (10 μCi/g body weight) were detected in the ciliary processes of mice by radioautography after intravenous injection. The pupillary response was not tested in this experiment. The mechanism of IOP reduction was discussed.

ISSN:0030-3755    

DOI:10.1159/000309928

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Preservation of intraocular pressure during routine opening of an eye in the pathology laboratory is important to retain the anatomic interrelationships. For this purpose we have devised a closed-chamber system by which the globe is held intact while it is bisected or while a calotte is excised.

ISSN:0030-3755    

DOI:10.1159/000309929

出版商:S. Karger AG    

年代:1988

数据来源: Karger