摘要:

We studied the relationship between intraocular pressure (IOP) and progression of visual filed loss in 83 eyes of 83 patients with advanced primary open-angle glaucoma (loss of at least one quarter of the visual field on Goldmann perimetry). During the 15-year follow-up study, 71 eyes (86%) showed progression of visual field loss. The mean IOP was significantly lower in eyes that remained stable (13.4 ± 1.3 mmHg) than in those that showed progression of visual field loss (19.4 ± 2.6 mmHg). These results suggest that it is necessary to reduce IOP to below 15 mmHg to prevent further progression of visual filed loss in advanced glaucoma.

ISSN:0030-3755    

DOI:10.1159/000310397

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

The pathophysiological mechanism involved in normal-tension glaucoma is still not fully understood. Besides intraocular pressure, vascular and rheological factors have been described. In the present study, the prevalence of silent myocardial ischemia in patients of the same age with normal-tension glaucoma, primary open-angle glaucoma and cataract was compared. Our findings indicate that in all three groups ischemic episodes occurred more frequently than described in normal people. The most striking observation, however, was the fact that in normal-tension glaucoma the frequency was twice that of the other two groups.

ISSN:0030-3755    

DOI:10.1159/000310398

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We measured angiographically the foveal avascular zone (FAZ) in 26 subjects with idiopathic juxtafoveolar telangiectasia (IJFT) and 27 control subjects. Quantitatively, FAZ was significantly smaller in IJFT (median = 0 mm2) than in controls (median = 0.405 mm2). Qualitatively, the telangiectasia in IJFT was temporal (92.5% of eyes) and appeared as microaneurysms interconnected with several capillaries, spider-shaped microaneurysms, or Coats’ like telangiectasia. IJFT is characterized by temporal telangiectasia and small FAZ.

ISSN:0030-3755    

DOI:10.1159/000310399

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Recent advances in the treatment of central retinal artery occlusion (CRAO) have resulted in a relatively good prognosis, but few studies have been reported. In the present study, electroretinography (ERG) was used to evaluate visual function recovery in 15 cases of CRAO. All patients were treated with ocular massage, intravenous urokinase and hyperbaric oxygenation. Of 15 cases, 8 had improved vision after treatment. A single flash ERG of 40 J from a xenon lamp was recorded before and during treatment. For ERG evaluation, the a- and b-wave amplitudes and the b/a wave amplitude ratio were analyzed. As control, the nonaffected eye of each patient was used. Before treatment, no significant difference was found in the a-wave amplitude between the two eyes, while a significant attenuation was found in the b-wave of the affected eye (p < 0.01). The b/a ratio was 0.73 ± 0.04 (mean ± SE) in the affected eye group and 1.08 ± 0.03 in the nonaffected eye group. It was significantly higher (p < 0.01 in eyes with improved visual acuity (0.83 ± 0.03) than in those with unimproved visual acuity (0.62 ± 0.05). The b-wave amplitude increased in accordance with visual improvement. We could thus demonstrate the temporal changes of ERG before and after treatment and show their correlation with the visual prognosis in patients with CRAO.

ISSN:0030-3755    

DOI:10.1159/000310400

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Using immunohistochemical techniques, we investigated the expression of leukocyte adhesion molecules – intercellular adhesion molecule-1 (ICAM-1), E-selectin (endothelial leukocyte adhesion molecule-1), and vascular cell adhesion molecule-1 (VCAM-1) – in various chronic inflammatory corneal diseases of different etiology. ICAM-1 was focally expressed on epithelial cells and showed an increased expression, on keratocytes, corneal endothelial cells, and vascular endothelial cells. E-selectin was present on vascular endothelial cells of several corneas, while VCAM-1 was found particularly on macrophages and only sporadically on vascular endothelial cells. Our results suggest that ICAM-1, E-selectin, and VCAM-1 may be involved in the pathogenesis of various chronic inflammatory corneal diseases, particularly in the selective recruitment of different leukocyte populations.

ISSN:0030-3755    

DOI:10.1159/000310401

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

A patient with nanophthalmic uveal effusion had a recurrence 7 months after the initial sclerectomies and sclerostomies. The effusion was cured by repeating the procedure. Specimens obtained at the first operation showed interlacing collagen lamellae and thin collagen bundles with an electron-dense deposit in the perifibrillar space. Specimens from the second operation showed disarranged collagen bundles with closely packed thin collagen fibrils. Collagen lamellae were not found. The regenerated scleral tissue was thought to interfere with the transscleral outflow and to block the bypass route, thus resulting in the recurrence of uveal effusion.

ISSN:0030-3755    

DOI:10.1159/000310402

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

An electroretinogram (ERG) and C-wave were recorded from 15 patients suffering from cone dysfunction syndrome. Our results show that the photopic ERG was diminished with extinction of the oscillatory potentials. On the other hand, the mean value of the C-wave amplitude was diminished and the implicit time prolonged. This may serve as a further diagnostic sign of the disease.

ISSN:0030-3755    

DOI:10.1159/000310403

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

A new focal pattern stimulator was developed. Since this system enables direct observation of ocular fundus during examination, it may be useful for the objective assessment of visual function in patients with various kinds of eye diseases.

ISSN:0030-3755    

DOI:10.1159/000310404

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Between November 1975 and December 1989, we examined 1,540 patients with age-related macular degeneration (ARMD). 297 eyes of 270 of these patients received photo-coagulation treatment (from L.S.A.) for exudative ARMD, including choroidal neovascular membranes (CNVMs) and retinal pigment epithelial detachment. Initially, only the bluegreen argon laser was available. From 1983 onwards we could choose between the blue-green argon, green argon and red krypton laser wavelengths. The 270 treated patients were followed for a minimum of 6 and a maximum of 168 months posttreatment (median 16 months). Of the 297 eyes, 138 received treatment with the blue-green argon, 36 with the green argon and 123 with the red krypton laser. Eyes with subfoveal and juxtafoveal NVMs were treated with the krypton laser. Also assigned to krypton photocoagulation were extrafoveal NVMs accompanied by hemorrhage. There was no statistical difference in the results of the three treatment modalities as judged by visual acuity. But, green argon is preferable to bluegreen argon since it is absorbed less by the xantophyll pigment. On the other hand, krypton laser appears to be at least as effective as green argon in extrafoveal neovascularization and is certainly the treatment of choice in subfoveal and juxtafoveal NVMs.

ISSN:0030-3755    

DOI:10.1159/000310405

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:0030-3755    

DOI:10.1159/000310406

出版商:S. Karger AG    

年代:1993

数据来源: Karger