摘要:

The participation of T lymphocytes in the immunopathogenesis of corneal opacity in herpetic stromal keratitis was investigated. In BALB/c mice infected intracorneally with herpes simplex virus type 1 corneal opacity was manifested 10 days after infection, while in athymic mice corneas remained almost clear. Histologically, all opaque corneas revealed stromal edema accompanied by the diffuse presence of polymorphonuclear cells and lymphocytes. When complement (C’)-treated immune spleen cells were adoptively transferred into athymic mice 6 or 72 h after corneal infection, stromal keratitis with mild opacity was observed 10 days after transfer. The athymic mice given anti-Thy 1.2 + C’-treated immune spleen cells failed to develop corneal opacity. The difference, as revealed by light and electron microscopy, was the presence or absence of lymphocytic infiltration and edema in the posterior third layers of the stroma and endothelial lesions. The endothelium was infiltrated by lymphocytes or macrophages and showed various stages of destruction. The main cause of corneal opacity in the early stage of herpetic stromal keratitis is thought to be stromal edema due to an adverse effect on the endothelium by immune T lymphocytes.

ISSN:0030-3755    

DOI:10.1159/000309886

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Of a 61-year-old woman with bilateral high myopia and bilateral juvenile cataract (which had been operated upon over 40 years ago), the blind and painful left eye was removed because of a tumour-like mass protruding from the pupil into the anterior chamber. Histological examination revealed this mass to be an anteriorly subluxated lens remnant with the posterior side touching the anterior face of the iris. Exclusively in this area of contact there was a typical lens-induced inflammatory reaction. We assume that this reaction could occur only because of the presence of vascular tissue, i.e. the iris stroma. Immunopathological considerations would seem to make this plausible.

ISSN:0030-3755    

DOI:10.1159/000309887

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Fabry’s disease has well-known characteristic morphological findings, i.e., the whorl-like corneal opacity and the posterior spoke-like cataract, etc. But its functional aspect has not been investigated fully. Thus, a 47-year-old male with Fabry’s disease was examined with Cochet-Bonnet’s esthesiometer, photokeratometry, ultrasonography, electropupillography, electroretinography, electro-oculography and fluorescein fundus angiography. Most of functional findings remained normal in spite of corneal opacity, cataract, retinal and conjunctival vascular tortuosity, choroidal vascular disturbance and delayed retinal circulation time. We discuss the reasons why significant functional disturbance has not developed.

ISSN:0030-3755    

DOI:10.1159/000309889

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Sisters with congenital vertical nystagmus are described in this report. In these 2 cases, the nystagmus on the electronystagmogram (ENG) showed a pure pendular pattern on forward gaze. Neurological examinations revealed no abnormality except for the nystagmus and visual disturbance. In the elder sister, the ENG showed that the intensity of the nystagmus decreased during eye closure and that there was no response to vertical optokinetic stimulation. We believe that the elder sister is the first case of congenital vertical pendular nystagmus confirmed by neuro-otological and neuro-ophthalmological examinations.

ISSN:0030-3755    

DOI:10.1159/000309890

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

In the hope of identifying an animal model for age-related macular degeneration (AMD) we undertook a pilot investigation of aged rhesus monkeys. Twenty-nine monkeys from a seminatural colony were examined at the Caribbean Primate Research Center. Macular drusen were found in 74% of the monkey eyes. Alterations of the retinal pigment epithelium within the macula were noted in 45% of the eyes. Fluorescein angiography in selected animals revealed window defects consistent with drusen. None of this sample showed the exudative form of AMD or disciform scarring. One typical monkey underwent special studies including measurement of visual resolution by electrophysiological study of the retinal and visual cortex. Application of human criteria to this animal supported the diagnosis of early AMD. Histopathologic study of one eye by transmission electron microscopy confirmed the presence of drusen with nearly identical ultrastructural features to those found in the human pigment epithelium in AMD.

ISSN:0030-3755    

DOI:10.1159/000309891

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The pecten oculi of the diurnally active pigeon (Columba livia) has been examined by light and electron microscopy. In this species the pecten is of the pleated type. It is situated over the optic nerve head and extends out into the vitreous. Fifteen to 17 accordion folds are joined apically by a heavily pigmented ridge of tissue which holds the pecten in a fan-like shape, widest at the base. The entire pecten is enclosed by a fine basal lamina. Within each fold are numerous capillaries, larger blood vessels and melanocytes. The capillaries are surrounded by thick fibrillar basal laminae which often contain pericytes. These capillaries display numerous microfolds on both the luminal and abluminal borders. The endothelial cell body is extremely thin with most organelles present in a paranuclear location. The melanocytes which are more plentiful in the bridge region form an incomplete sheath around the capillaries and other blood vessels. The morphology of the pecten in the pigeon is indicative of a heavy involvement in the transport of materials.

ISSN:0030-3755    

DOI:10.1159/000309892

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Lymphomatoid granulomatosis is an angiocentric and angiodestructive lymphoproliferative disorder involving multisystems but rarely conjunctiva. We present a 62-year-old Chinese female with lymphomatoid granulomatosis who had an ulcerative conjunctival nodule. Conjunctival biopsy revealed pathological findings important for diagnosis and indicating progression of disease severity. To our knowledge, this is the first report to demonstrate pathological findings characteristic of lymphomatoid granulomatosis with conjunctival involvement.

ISSN:0030-3755    

DOI:10.1159/000309893

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:0030-3755    

DOI:10.1159/000309894

出版商:S. Karger AG    

年代:1988

数据来源: Karger