ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02878.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02879.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02880.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Eight healthy men received 100 mg oral doses of etretinate separated by two‐week washout periods in an open, randomized, crossover study. Etretinate was administered during a complete fast, with a standard high fat breakfast, a standard high carbohydrate breakfast, and 16 ounces of whole milk. Plasma samples were obtained at specific times over a 48‐hour period. Plasma concentrations of etretinate as well as two of its major metabolites were determined by a specific, reverse‐phase, high‐performance liquid chromatography method. Plasma concentrations of etretinate were greater when administered with a high fat meal and whole milk compared to ingestion with a high carbohydrate meal or during a complete fast. In contrast, there was no increase in the plasma concentrations of the active metabolites following any of the meals. These data indicate that chronic dosing of etretinate with milk or a high fat meal compared with fasting conditions will result in higher concentrations of etretinate, which may ultimately lead to higher metabolite concent

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02881.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02882.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The relative potency of intravenous indoprofen and intramuscular pentazocine in postoperative pain was evaluated. Indoprofen was administered in 200‐ and 400‐mg single doses and pentazocine was given in 15‐ and 30‐mg doses. Pain was assessed at different time intervals, and additional medication consumption was recorded, as well as side effects and overall evaluations. An analysis of peak pain intensity difference (PID) has shown a significant dose‐effect relationship for both drugs and a potency ratio of 1:7 between indoprofen and pentazocine (mg to mg). Based on the frequency of patients requiring remedication and those reporting total pain relief in at least one instance, the potency ratio of indoprofen:pentazocine was 1:13 and 1:10, respectively. The mean peak PID of the pooled data for both doses of each drug was significantly greater for indoprofen. Intravenous indoprofen 400 mg was ranked the most effectiv

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02883.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The antihypertensive effect of carteolol, a new potent nonselective beta‐adrenergic antagonist, was investigated in a double‐blind, parallel study of 35 patients with mild‐to‐moderate, essential hypertension whose blood pressures were not adequately controlled with a diuretic. Patients were randomly assigned to receive placebo, carteolol 5 mg, or carteolol 20 mg once a day in addition to hydrochlorothiazide 50 mg for six weeks. Thirty‐four patients completed the study: 11 patients received placebo (group 1), 12 patients received carteolol 5 mg (group 2), and 11 patients received carteolol 20 mg (group 3). After six weeks of treatment, the two groups that received carteolol had significant reductions in systolic (SBP) and diastolic (DBP) blood pressure from baseline in both the supine and standing positions. In group 2, mean SBP decreases for supine and standing positions were 11 ± 2.1 and 11 ± 1.9 mm Hg, respectively (P<.01) and 8 ± 1.2 and 9 ± 1.3 mm Hg, respectively, for DBP (P<.01); whereas in group 3, values were 8 ± 2.8 and 12 ± 3.0 mm Hg for SBP, in 5 ± 1.9 and 9 ± 3.1 mm Hg, respectively, for DBP (P<.01). The hypotensive effect was associated with slight but significant decreases in heart rate (P<.01 in group 2 andP<.05 in group 3). Reductions in SBP and DBP with the 20‐mg dose were not significantly different from those with the 5‐mg dose. With both carteolol regimens, the fall in mean blood pressure did not correlate with the initial level; but in the group taking the 5‐mg dose, it did correlate significantly with the decrease in heart rate (r =.72, P<.01). Side effects attributable to carteolol were infrequent and did not persist during continued therapy. It is concluded that carteolol, when combined with hydrochlorothiazide, is effective in reducing blood pressure in patients with mild t

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02884.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02885.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02886.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0091-2700    

DOI:10.1002/j.1552-4604.1985.tb02887.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY