摘要:

A group of 17 hyperprolactinemic women was given 200 mg of nomifensine orally to evaluate its diagnostic potential to discriminate between tumors and nontu-morous hyperprolactinemia. The nomifensine suppressive effect on prolactin serum levels was not significantly different between patients with or without enlargement of the sella turcica. A control group of 5 women with normal prolactin levels exhibited a nomifensine suppressive effect below 65% of the baseline prolactin level, which was significantly different from that in the hyperprolactinemic group. In conclusion it is confirmed that the nomifensine test provides no value in the early diagnosis of the prolactinoma.

ISSN:1663-2818    

DOI:10.1159/000179458

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

8 male collegial athletes were submitted at random to three (55, 70 and 85% of VO2 max) ergocycle exercises of 20-min duration. Venous blood samples were obtained before, during and after ergocycling sessions by antecubital catheterization. Serum prolactin was measured by RIA using specific antiserum. The exercise treatments induced a blood prolactin response proportional to the intensity of the work loads.

ISSN:1663-2818    

DOI:10.1159/000179459

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The growth hormone and prolactin response to oral bromazepam (3 mg) was assessed in 5 normal men and 5 normal women. A peak growth hormone response of 11.9 ± 3.7 ng/ml (mean ± SD), significantly above the baseline (p < 0.01), was achieved in the men. On the other hand, there was no statistically significant response of growth hormone secretion in the women. No change in prolactin secretion was observed in either se

ISSN:1663-2818    

DOI:10.1159/000179460

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effect of acute and chronic cimetidine administration on glucose tolerance and insulin secretion was studied in healthy male volunteers. Cimetidine was administered intravenously (4 mg · kg-1 followed by 0.7 mg · kg-1 · h-1) in acute studies and by oral route (1 g/die for 4 weeks) in long-term studies. Oral (100 g) or intravenous (0.5 g · kg-1) glucose was used as a stimulus for insulin secretion in both studies. Neither acute nor chronic cimetidine administration modified insulin secretion and glucose tolerance. These data are consistent with the idea that H2-receptors are not involved in the insulinogenic effect of gluc

ISSN:1663-2818    

DOI:10.1159/000179461

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effect of arginine infusion on blood glucose and plasma levels of insulin, C-peptide and glucagon has been studied in leukemic children before and after treatment with L-asparaginase (10,000 U/m2/day for 10 days). Therapy induced a significant reduction in basal and peak blood glucose, insulin and C-peptide levels, while glucagon was unmodified. The conserved C-peptide-insulin molar ratio suggests the interference of L-asparaginase with proinsulin synthesis. In conclusion our results prove a decreased insulin reserve with a preserved, although reduced, beta-cell function.

ISSN:1663-2818    

DOI:10.1159/000179462

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Pituitary content and concentration of LH and FSH were measured by radioimmunoassay from birth to adulthood. The pituitary contents and concentrations of both gonadotropins increased from birth to 70-90 days, then reaching adult levels. 1 µg/100 g body weight of synthetic LHRH was administered to immature (25 and 55 days of age) and adult male rabbits. LH and FSH were measured in plasma samples taken just before and 30 min after LHRH injection. At all stages studied, LHRH significantly increased circulating LH and FSH. The FSH response at 55 days and at adult age was lower than that of LH. There was a peripubertal increase of the mobilizable pituitary reserve of LH while the FSH reserve slightly but not significantly increased. This change in the pituitary responsiveness to LHRH could play a role in pubertal processes

ISSN:1663-2818    

DOI:10.1159/000179463

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The amount of 125I-insulin associated with freshly isolated hepatocytes was increased 50% in the presence of 0.2 mM chloroquine (CQ) after 2 h of incubation. The degradation of insulin by the hepatocytes incubated with CQ was significantly diminished as compared with control cells. Hepatocytes incubated with 125I-insulin in the presence of CQ showed a slower rate of ligand dissociation than control cells. More TCA-precipitable and less TCA-soluble material appeared in the dissociation buffer of CQ-treated cells. However, CQ inhibited only 25-35% of intracellular insulin degradation. Non-lysosomal intracellular insulin degradation appears to be responsible for the remaining portion of the ligand degradation by isolated hepatocytes.

ISSN:1663-2818    

DOI:10.1159/000179464

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In autoradiograms of mammary glands of rats on days 18 and 20 of pregnancy and day 6 of lactation after injection of 3H 1,25-(OH)2 vitamin D3, a nuclear concentration of radioactivity is observed in alveolar and ductal cells, as well as in cells of the epidermis of the nipple. Myoepithelial cells and connective tissue cells do not concentrate the hormone in their nuclei. The nuclear radioactivity appears specific, since 1,25-(OH)2 vitamin D3 but not 25-(OH)2 vitamin D3 prevents the uptake. The results suggest the existence of nuclear receptors for 1,25-(OH)2 vitamin D3 in mammary tissues and thus complements previous biochemical evidence showing the presence of cytoplasmic receptors for the hormone in mouse mammary glands; in addition, our results allow the identification of the cell types possessing the receptors.

ISSN:1663-2818    

DOI:10.1159/000179465

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

We have recently shown that beside a general stimulation of most adrenal proteins, corticotropin induces a marked increase in a specific adrenal cytosolic protein, protein E. in intact and hypophysectomized rats. To further clarify the mechanisms by which corticotropin exerts its trophic action we have investigated the effects of cycloheximide, calcium and calcium chelator administration on intact and hypophysectomized animals. These substances were injected in rats with or without corticotropin, and slices of adrenal glands from control and treated animals were removed 5 h later, incubated with [14C]- or [3H]-leucine for 2 h, and cytosolic proteins analyzed by polyacrylamide gel electrophoresis using a dual labelling technique. When high doses of cycloheximide (higher than 500 µg) were injected in rats, incorporation of labelled leucine in adrenal slices of control and corticotropin-treated animals was inhibited. With 500 µg cycloheximide per rat, incorporation of labelled leucine in adrenal slices of control animals was normal, but the corticotropin stimulation of both protein E and total protein synthesis was inhibited. Lower doses of cycloheximide (100 µg per rat) completely inhibited the stimulatory effect of corticotropin on total protein synthesis but did not affect protein E synthesis, while after 50 µg per rat both stimulatory effects were preserved. The two higher doses of cycloheximide (500 and 100 µg per rat) could not completely block the steroidogenic effect of the hormone. The effects of calcium and calcium chelators were studied in 1-day hypophysectomized rats. Calcium alone or injected simultaneously with corticotropin has no effect. Calcium chelators injected simultaneously with corticotropin partially inhibited the stimulatory effects of corticotropin on steroidogenesis but totally inhibited stimulation of total protein synthesis, while the stimulation of protein E persisted. Our results show that after corticotropin, stimulation of protein E synthesis correlates better with steroidogenesis than with total protein synth

ISSN:1663-2818    

DOI:10.1159/000179466

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000179467

出版商:S. Karger AG    

年代:1981

数据来源: Karger