摘要:

It has been shown that repeated doses of a long-acting synthetic ACTH preparation (Synacthen Depot®) are able to restore adrenal function in rats with adrenal atrophy (induced by hypophysectomizing the animals and leaving them untreated for varying periods of time). Restoration of responsiveness to single doses of synthetic ACTH (Synacthen®) can be effected after a relatively short time (10 days’ treatment is sufficient for this purpose); restoration of adrenal weight, how ever, calls for at least 30 days’ treatment with the doses used in this study. In other words, the animals’ adrenals, though greatly reduced in size, are nevertheless capable of displaying a virtually normal response to stimulation. This discrepancy indicates that, during the stimulation test, they must be more active than normal adrenals. This phenomenon cannot be accounted for at

ISSN:1663-2818    

DOI:10.1159/000178185

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Androgen treatment during the critical neonatal period in themouse leads to a marked change in the evolution of the reproductive performance. Though ovulation occurs in most animals in the early mature period, 25% of the androgenized mice are sterile. The mice that prove to be fertile do not develop young after the first insemination apparently due to a faulty maternal milieu caused by a temporary incompetence of the endometrium. The total reproduction capacity is reduced by more than half. The fertility span of the androgenized mice is shortened due to the late appearance of first litters and the early onset of secondary sterility. The early failure of the uterus to support developing embryos and thereby initiating the end of reproduction suggests an early aging of the uterus.

ISSN:1663-2818    

DOI:10.1159/000178186

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

A pronounced lipolytic activity was found in homogenate of rat adrenal gland. The pH optimum of adrenal lipase was wide and the highest lipolytic activity was found at pH 8.5. An inhibition of lipolytic activity in the presence of 1 M NaCl, protamine sulphate, diisopropylfluorophosphate at pH 8,5 and after the addition on NaF at pH 7.2 was noted. Heparine activated the lipase activity at pH 8.5. These result suggested that both lipoprotein like lipase and neutral ‘tissue’ lipase are present in rat adrenal gland. An activation of adrenal lipase activity with ACTH and 3’5’ cyclic adenosine monophosphate was demonstrated. The other pituitary hormones and adrenaline did not increased the adrenal lipase a

ISSN:1663-2818    

DOI:10.1159/000178187

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Topochemical, radio chromatographical, electron microscopic studies about 3 cases of family goitre by deficiency of deiodase. Protein synthesis is almost directed towards cell-division and co-exists with a dishormogenesis, pointed out by extracellular losses of iodotyrosins (MIT and especially DTT), the insufficient synthesis of tyronins (T3 and especially T4) and the inconsistency of the extracellular storage process of thyroglobulin. The alteration of the mitochondrial apparatus shows that, at least partially, the activity of mitochondrial enzyme is deficient. The absence of microvilli, the reduced number of lysosomes, the poorness of the cytoplasmic fundamental matrix are still other factors which point to the existence of an abnormal quantitative and qualitative secretory cycle. Our results show that the ultra-structural lesions of family goitres by deficiency of deiodase differ from structural troubles pointed out for goitres by a deficiency of organification of iodine and reproduce only partially the cyto-structure of embryonic thyroid.

ISSN:1663-2818    

DOI:10.1159/000178188

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

At a stage when histological damage detectable witha light microscope is slight, various indices of the thyroid function in rats immunized with total homologous thyroid extract are impaired, suggesting the existence of a ‘pre histological’ stage of isoimmune thyroiditis. The data indicate alterations of iodine utilization and hormone secretion, since the radioiodine fixation curve, iodinated amino-acids and iodothyronines concentrations in the thyroid, as well as proteolytic activity and protein bound iodine in serum, are significantly affec

ISSN:1663-2818    

DOI:10.1159/000178189

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000178190

出版商:S. Karger AG    

年代:1970

数据来源: Karger