摘要:

Thyroid function was studied in 27 subjects who underwent bronchography with propyliodone (18–70 ml, containing 30% of organic iodine). Sustained elevations of serum non-hormonal iodine were observed, indicating that significant amounts of propyliodone were absorbed from the bronchial tree and also that elimination may take several weeks. During the period of anaesthesia, there was an increase in thyroxine-binding globulin and all thyroid hormones which was transient and probably reflected vascular response to the anaesthetic. T4-T3 conversion was inhibited with a nadir of T3 and a peak of rT3 occurring on the 2nd day after propyliodone exposure. FT4 increased gradually during the 2 weeks after bronchography, but remained within the normal range. 6 out of the 27 patients developed pathologic T4 levels, 3 elevated T3 levels, and 2 an abnormal response to thyrotropin-releasing hormone; these changes might have been confused with hyperthyroidism. None of the patients developed clinical thyrotoxicosis; however, in patients with autonomous thyroid tissue, the same precautions should be taken with propyliodone as with other iodine-containing agents which are known to induce hyperthyroidism in this situatio

ISSN:1663-2818    

DOI:10.1159/000179686

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

To explore a possible downward setting of the hypothalamic osmoreceptors in the hyponatremia of hypothyroidism, 4 adolescent patients with hypothyroidism were studied. Plasma and urine osmolality were measured on random paired simultaneous samples, and following a water load. The osmotic threshold was determined by the isovolemic infusion of hypertonic NaCl, and compared to the osmotic threshold of 6 healthy subjects. Random paired urine and plasma osmolality revealed inappropriately high urine osmolality for the given plasma osmolality. A water load produced a normal dilution of urine. Osmotic threshold was found at plasma osmolality of 286–287 mosm/kg, compared to 286.7 ± 1.0 in 6 normal individuals. It is concluded that none of the known types of the syndrome of inappropriate ADH secretion could account for the hyponatremia in the hypothyroid patients, and that patients with hypothyroidism have normal osmoreceptors as measured by the osmotic threshold te

ISSN:1663-2818    

DOI:10.1159/000179687

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

We have evaluated the use of urinary vasopressin (AVP) measurements in human newborns to see if urinary AVP excretion is a true reflection of the plasma level. AVP was measured in 37 simultaneously collected plasma and urine samples. The correlation coefficient was 0.8 (p < 0.001). AVP extracted in duplicate from six urine samples was measured by bioassay and radioimmunoassay. The correlation coefficient was 0.85 (p < 0.05). To facilitate long-term urine collection we have developed a urine collecting tray to fit a standard incubator or cot. Urinary AVP was measured in 24-hour urine collections in 37 normal infants. AVP excretion was higher in the first 48 h of life than subsequently. Continuous 4-hour urine collections were made in 1 sick infant to assess AVP excretion when urine flow is variable.

ISSN:1663-2818    

DOI:10.1159/000179688

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The diazoxide infusion test (600 mg i.v. over a 1-hour period) was performed in 12 patients bearing single benign islet B-cell adenoma and in 6 normal subjects. Blood glucose, plasma insulin and glucagon concentrations were measured every 15 min during the infusion and thereafter up to 150 min. In insulinoma patients, blood glucose levels failed to increase significantly while in the control group a significant rise starting from 30 min persisted throughout the test (p < 0.05 or less). Plasma insulin mean levels decreased significantly in normal subjects from 30 to 60 min (p < 0.05), while they were significantly suppressed in hypoglycemic patients from 15 to 120 min (p < 0.02). Diazoxide administration induced in the normal group a significant decrease in glucagon levels (p < 0.02 from 30 to 150 min) whereas no such suppression occurred in patients. In our experience, insulin response to diazoxide infusion in patients with insulinoma may provide additional information for diagnosis.

ISSN:1663-2818    

DOI:10.1159/000179689

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The major objective of this study was to investigate the analogy existing between the typical circadian periodicity of ACTH and that recently described of β-lipotropin (β-LPH) and β-endorphin (β-EP) plasma levels. The determination of their concentrations, plus cortisol, has been performed on the same plasma samples of 6 healthy volunteers. All hormones were measured by radioimmunoassay. Those of β-LPH and β-EP were preceded by a purification of plasma through silicic acid extraction and Sephadex G-75 gel filtration. The highest values (mean ± SEM) were found in the morning (ACTH: 10.3 ± 0.9; β-LPH: 6.3 ± 0.7; β-EP: 6.5 ± 0.5 fmol/ml; cortisol: 378 ± 30 pmol/ml) and the lowest values in the evening (ACTH: 6.1 ± 0.7; β-LPH: 3.3 ± 0.4; β-EP: 3.7 ± 0.6 fmol/ml; cortisol: 130 ± 23 pmol/ml). Statistical analysis using the Fourier method led to the evidence of a concomitant circadian secretory pattern of the three proopiocortin-related peptides. These results strongly suggest that the phasic secretion of ACTH, β-LPH and β-EP underlies a co

ISSN:1663-2818    

DOI:10.1159/000179690

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A rapid specific radioimmunoassay for progesterone in mixed, unstimulated saliva is described. Column chromatography is not necessary. One single extraction with petroleum ether provides a fractional recovery of 75–95%. The assay sensitivity is 9 pg progesterone/tube. The intra- and interassay variation for low, medium, and highly concentrated progesterone pools is 13.1–9.5 and 17.4–13.9%, respectively. Analytical recovery documents excellent correlation between expected and detected progesterone concentrations (r = 0.994). Data from salivary progesterone of a regularly menstruating girl and of a patient with XO Turner’s syndrome are p

ISSN:1663-2818    

DOI:10.1159/000179691

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

To estimate the possible involvement of a peripheral serotonergic pathway in the mechanism of the aldosterone-stimulating effect of metoclopramide (M) the plasma aldosterone (PA), renin activity (PRA) and prolactin (PRL) response to M was studied in 6 normal subjects before and after administration of ketanserin (K), a pure, specific, and selective blocking agent of 5-hydroxytryptamine type 2 (5-HT2) receptors. With K preadministration the M-induced increase of PRL was similar to that observed in control conditions, in accordance with the specific and peripheral antiserotonergic action of the drug. K potentiated the PA and PRA elevation in response to M. These data suggest that the PA response to M is not related to M’s agonist activity at the peripheral 5-HT2 receptors level. The results further indicate that K can induce an enhancement of the activity of renin-angiotensin-aldosterone system with an higher PRA and PA response to stimulatory action of

ISSN:1663-2818    

DOI:10.1159/000179692

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In vivo and in situ subcutaneous injection of 30 µCi of 3H-estrone (3H-E1) to guinea pig fetuses was carried out to study the dynamics of the selective uptake and retention of this estrogen in the uterus and other fetal organs. In the fetal uterus an increase in the uptake of radioactivity with time was found which was maximal 1 h after injection of 3H-E1. The analysis of radioactive material showed that in the fetal uterus unmetabolized 3H-E1 accounts for 65–75% of the total radioactivity between 10 and 60 min after the injection and its maximal concentration is 2.5–15 times and 10 times higher than the maximal concentrations found in other fetal organs and fetal plasma, respectively. Significant amounts of 3H-E1 were also present in lung (33–60% of the total radioactivity in this tissue), brain (37–52%) and ovary (18–47%), while an important conversion of 3H-E1 into 3H-estradiol was observed in the kidney (20–26 %). Estrogen sulfates, essentially estrone sulfate, represented the greater part of the fetal plasma radioactivity (30–49%). 3H-E1-specific binding sites in the cytosol of the fetal uterus were found with physicochemical characteristics (specifically limited to natural and synthetic estrogens, Kd = 8.1 ± 1.2 × 10-10M(SD), sedimentation coefficient 8S) similar to those of the typical estrogen receptor. The cytosol receptor-3H-E1 complex has a dissociation rate constant (K-1) of 16 ± 0.7 × 10-4 s-1 at 25 °C. The responsiveness of the fetal uterus to estrone treatment was studied after subcutaneous administration of estrone to pregnant guinea pigs (1 mg/kg/day for 3 consecutive days). Two biological responses were observed: an increase in fetal uterine weight (50–100% in relation to the nontreated animals) and a significant stimulation of progesterone receptor protein (10–16 times higher than in control animals). At the same time, there was a 50–70% decrease in the total estrog

ISSN:1663-2818    

DOI:10.1159/000179693

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000179694

出版商:S. Karger AG    

年代:1983

数据来源: Karger