摘要:

The AA induced isoimmune thyroiditis in the guinea pig using homologous total thyroid extract. They studied carefully the most intimate ultrastructural alterations in basal conditions and after a single TSH stimulation. About 20% of follicles were grossly damaged, with very little signs of function and did not respond to TSH. About 70% of follicles were less damaged, with very rudimental functional aspects and did not respond to TSH. Only 10% of follicular units, with small alterations of epitelial cells exhibited quite slight changes after the tropin. Very small interstitial infiltration is detectable at the immunization time considered.

ISSN:1663-2818    

DOI:10.1159/000178239

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Thyroxine by displacement analysis (T4D) along with the resin-T3 (RT3) and resin-T4 (RT4) ratios were determined analytically on serum samples from 160 ‘normal’, 50 hypothyroid and 70 hyperthyroid persons. From these data, the mathematical products of the T4D and either the RT3 or RT4 ratios were calculated and then designated the free thyroxine indices (FTI-T3 and FTI-T4). These were compared to the mean value ± 3 SD range derived from 137 normal blood bank samples. The T4D used alone was the single most accurate diagnostic parameter. The RT3 and RT4 were singularly poor tests for discriminating thyroidal dysfunction from normal. Despite theoretic considerations, the FTI-T4 was superior in diagnostic discrimination compared to the FTI-T3 with 93.8% ‘normal’ but only 16.0% hypothyroid and 0.0% hyperthyroid values in the normal range. The FTI-T4 showed a linear correlation with the free thyroxine concentration obtained by equilibrium dialysis. The FTΓ-T4 is particularly advantageous for clinical use since it is derived from the T4D which obviates interferences from iodine contamination and the RT4 which can be performed in concert with the T4D by a unified

ISSN:1663-2818    

DOI:10.1159/000178240

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Exophthalmos usually did not appear nor did pre-existent exophthalmos progress in thyrotoxic patients treated with desiccated thyroid in full replacement dosages, 2½ to 3 grains per day, simultaneously with thyroid blocking agent therapy, 131I administration, or thyroidectomy. Indeed, in most patients so treated, exophthalmos present prior to therapy of the hyperthyroidism decreased or disappeared. Our observations are consonant with the hypothesis that full replacement dosages of thyroid hormones started at essentially the same time that treatment of the thyrotoxic state is initiated may provide prophylaxis against the appearance or the progression of the exophthalmos which follows treatment of thyrotoxicosis. We do not intend to suggest, however, that exophthalmos which appears, progresses, or enters a malignant phase after successful treatment of hyperthyroidism at some time in the past is benefited by such treatment

ISSN:1663-2818    

DOI:10.1159/000178241

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

After reviewing the incidence of diabetes and hypertension as associated diseases, 1,000 cases of diabetes and 1,000 cases of arterial hypertension are reviewed. The statistical results permit us to affirm that there is no direct relation between the two diseases. If hypertension seems to be somewhat more frequent in diabetics than in the general population, this is due to vasculorenal or endocrine alterations which, with relative frequency associates with or are complications of the same diabetes, but this does not support the existence of a common etiopathogenic link.

ISSN:1663-2818    

DOI:10.1159/000178242

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

40 consecutive pregnancies following treatment of infertile women with gonadotrophins were investigated. The 24-hourly excretion of oestriol, pregnanediol and chorionic gonadotrophin was measured at weekly intervals and correlated with the clinical findings. 23 pregnancies resuited in single babies, 6 in twins, 1 in triplets and 10 in abortion. Twelve single pregnancies were clinically normal and were used as a control group to estimate the mean and 95% confidence limits of the 24-hour excretions, and the mean and 95% confidence limits of the weekly rates of increase of each hormone excreted. These figures were used to determine if threatened abortion, abortion, pre-eclamptic toxaemia or multiple pregnancy could be predicted from the excretion of the hormones. Abnormally low excretion of at least 1 of the steroids occurred before clinical evidence of threatened abortion in 4 of 10 cases, abortion in 6 of 10 cases and pre-eclamptic toxaemia in 3 of 8 cases. The excretion of all steroids appeared to be raised in multiple pregnancies but the difference between the mean of these and the mean for single pregnancies was not significant, probably because of the wide scatter. The usefulness of hormone assays in pregnancy is discussed.

ISSN:1663-2818    

DOI:10.1159/000178243

出版商:S. Karger AG    

年代:1971

数据来源: Karger