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| 1. |
A Clinical and Laboratory Study of Some Metabolic and Hormonal Effects of CI-583 Na Compared with CI-440 and Indomethacin in Patients with Rheumatoid Arthritis |
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Hormone Research in Paediatrics,
Volume 1,
Issue 4,
1970,
Page 193-208
De Salcedo,
M.D. Carrington,
Almeida Santos,
Luis Silva,
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摘要:
In this trial we have studied the following parameters: (1) Clinical improvement of rheumatoid arthritis, (2) changes in protein-binding of plasma cortisol, (3) changes in protein-binding of thyroid hormone, (4) changes in fibrinolytic activity of plasma, and (5) adverse reactions attributable to medication. We have studied 30 male or non pregnant female in-patients during a four week period. They were classified according to the A.R.A. criteria. From our study it seems quite probable that the anti-flogistic effects of these drugs may be due in part at least to an increased adrenocortical secretion of cortisol or to an increase of its free fraction. In most of the cases it is evidently impossible to correlate analytical and clinical effects. So, we must assume that on present grounds of our knowledge the therapeutic effects are largely independent of the results obtained.
ISSN:1663-2818
DOI:10.1159/000178181
出版商:S. Karger AG
年代:1970
数据来源: Karger
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| 2. |
Abnormal Iodoproteins in Human Congenital Goiter |
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Hormone Research in Paediatrics,
Volume 1,
Issue 4,
1970,
Page 209-227
M. Andreoli,
F. Monaco,
M. D’Armiento,
S. Fontana,
G. Scuncio,
G.B. Salabé,
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PDF (1745KB)
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摘要:
Soluble iodoproteins from three congenitally goitrousthyroids have been isolated by salt fractionation followed by DEAE-cellulose chromatography, gel filtration and density gradient centrifugation and characterized by analytical ultracentrifugation, polyacrylamide electrophoresis and by immunological procedures. It has been shown that the amount of 19 S thyroglobulin is strikingly decreased, the soluble proteins consisting of several slow-sedimenting iodocompounds: (3 S-6S) not identified as any of the known thyroglobulin subunit. The immunological data suggest that some of the heterogenous 3 S-6 S fractions is related to the thyroglobulin metabolism.
ISSN:1663-2818
DOI:10.1159/000178182
出版商:S. Karger AG
年代:1970
数据来源: Karger
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| 3. |
Difficulties in the Diagnosis of Hypothyroidism in Old Age, in Young Women and in Schoolchildren |
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Hormone Research in Paediatrics,
Volume 1,
Issue 4,
1970,
Page 228-232
V.C. Medvei,
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PDF (598KB)
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摘要:
Difficulties in the diagnosis of Hypothyroidism mayoccur in the above age groups. The presentation of the disease may be oligosymptomatic. Ignorance of the social background may be misleading. To illustrate this, five case histories and Pendred’s syndrome are discusse
ISSN:1663-2818
DOI:10.1159/000178184
出版商:S. Karger AG
年代:1970
数据来源: Karger
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| 4. |
Mechanism of Hormonal Action |
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Hormone Research in Paediatrics,
Volume 1,
Issue 4,
1970,
Page 233-256
Ronald S. Snart,
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PDF (2567KB)
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摘要:
A review of evidence supporting a general mechanism of action of steroid hormones has been made by comparing the action of aldosterone in stimulating sodium transport across toadbladder, with corticosterone stimulation of gluconeogenic enzymes in rat liver and oestradiol binding in rat uterus. Related aspects of the mechanism of action of neurohypophyseal hormones have been considered in terms of the ‘pore’ and cyclic AMP theor
ISSN:1663-2818
DOI:10.1159/000178183
出版商:S. Karger AG
年代:1970
数据来源: Karger
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