摘要:

4 patients with presumed pituitary hypothalamic sarcoidosis are described. 3 had histological diagnoses compatible with sarcoidosis and in the other this diagnosis was strongly suspected from chest X-rays. 2 patients presented with diabetes insipidus. ACTH reserve was diminished in 3 out of 4 and growth hormone reserve was diminished in the 3 who were tested. All 4 patients developed secondary amenorrhea. 3 patients had hypothalamic hypothyroidism. Prolactin dynamics were intact. Tomograms of the sella turcica in all 4 and computerized tomography of the hypothalamic area in 2 patients failed to reveal any abnormality.

ISSN:1663-2818    

DOI:10.1159/000179099

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The plasma insulin and blood glucose responses to synthetic 1-24ACTH were studied in 21 patients bilaterally adrenalectomized for pituitary-dependent Cushing’s syndrome and in 8 healthy adults. In the adrenalectomized patients, intravenous 1-24ACTH administration was followed by an increase in plasma insulin concentrations after 15 and 30 min and a fall in blood glucose after 30 min. In healthy subjects no significant changes in plasma insulin and blood glucose levels were found. The presence of intact adrenals seems to be the cause of the different responses of insulin to 1-24ACTH injection in these two group

ISSN:1663-2818    

DOI:10.1159/000179100

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The effect of hypo- and hyperglycemia on the renin-aldosterone system was studied in 10 endocrinologically normal children. Insulin-induced hypoglycemia caused an elevation of plasma renin activity (PRA) up to 371 ± 23% (mean ± SEM) over the basal level (p < 0.001) and of the plasma aldosterone level up to 243 ± 7% (mean ± SEM) over the basal values (p 0.05) and a reduction in the plasma aldosterone level to 53 ± 12% (mean ± SEM, p < 0.01). It is suggested that the widely used diagnostic procedures, the insulin tolerance and oral glucose tolerance tests, be also applied for the investigation of the renin-aldosterone

ISSN:1663-2818    

DOI:10.1159/000179101

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The effect of fluoxymesterone (FMA), a fluorinated androgen, on ovum implantation has been studied using ovariectomized, progesterone-treated pregnant (‘delayed’) mice. 500 µg FMA, given either continuously from day 4 to 9 or singly on day 8, was able to induce implantation but at the same time caused total resorption of implanted embryos in the case of prolonged treatment with the drug. This anti-estrogenic activity of FMA could be reversed by supplementation of 0.25 µg estradiol-17β given on day 8. Testosterone also induced implantations in ‘delayed’ mice. FMA and testosterone given to long-term ovariectomized, progesterone-primed mice showed characteristic changes in uterine epithelial cell morphology similar to the attachment found in normal pregnancy. The possible mechanism of action of FMA in early pregnancy will be

ISSN:1663-2818    

DOI:10.1159/000179102

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Human choriogonadotropin (hCG) was labelled with 125I using a low temperature (4°C), minimal chloramine-T (10 µg) concentration and 20-sec oxidization. The structural integrity of labelled hCG was analyzed immediately after the labelling as well as after storage for 7 and 14 days at 4 or –15°C by gel filtration on a Sepharose 6B and Sephadex G-200 column and by polyacrylamide gel electrophoresis. Gel filtrations of freshly labelled hCG revealed a single radioactive peak (Kav = 0.52 and 0.33) corresponding to the intact unlabelled hCG. Polyacrylamide gel electrophoresis also showed a high homogenity of labelled hormone. The capability of freshly labelled hCG to bind to LH(hCG) receptor was 51% and to anti-hCG γ-globulin Sepharose 4B, 94%. Storage for 14 days at 4°C caused a complete change of the molecule to a smaller conformation (Kav = 0.62 and 0.41) accompanied by a marked reduction in the binding to LH(hCG) receptor (12%). The binding to specific antibody remained high (75%). No change in the structure was found when the labelled hormone was stored for 14 days at – 15°C. The hormone also exhibited high binding to the LH(hCG) receptor (45%) and to specific antibody (86%). SDS-polyacrylamide gel electrophoresis indicated that over 90% of the radioiodine present in labelled hCG was associated with the α-subunit. No difference was found in the disappearance rate of freshly labelled and fresh unlabelled hCG from the circulation of the rat after a single intravenous injection. The rate of disappearance of the structurally changed hormone was, however, markedly increased and was found to be due to the higher uptake of the hormone by the kidneys and liver. The present observations indicate that hCG retains well its structural integrity and capability to bind to LH(hCG) receptor and specific antibody when radioiodinated with the chloramine-T method. However, there occurs a rapid structural change in labelled hormone molecules under storage at 4°C leading to a smaller conformation, a marked reduction in its binding capability to LH(hCG) receptor and altered metabolic clearance

ISSN:1663-2818    

DOI:10.1159/000179103

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The maturation of the potential for ovulation in man is reviewed in the light of recent data quantitating gonadotropins and gonadal steroids in the prepubertal child. The primary limitations of the hypothalamic-pituitary-gonadal axis are seen as related to feedback control mechanisms. Based on preliminary data obtained in patients with gonadal dysgenesis, a hypothesis which links positive and negative feedback maturation is proposed. The development of full reproductive potential in man is clearly a process which extends over a decade or more.

ISSN:1663-2818    

DOI:10.1159/000179104

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000179105

出版商:S. Karger AG    

年代:1980

数据来源: Karger