摘要:

5 prepubertal boys with unilateral cryptorchidism and compensatory hypertrophy of the descended testicle, 22 prepubertal boys with unilateral cryptorchidism and without CTH, and 14 prepubertal normal boys were submitted to LH-RH and to HCG tests in order to study the hormonal behaviour in CTH phenomenon before puberty. High but normal peaks of plasma LH and FSH were observed after LH-RH in CTH boys who showed a significant increase of testosterone after HCG stimulation. On the contrary the LH response to LH-RH and the testosterone response to HCG of the boys with unilateral cryptorchidism and without CTH were, as expected, significantly lower than in the control ones.

ISSN:1663-2818    

DOI:10.1159/000178912

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

An original method for 5-androsten-3β,17β-diol (A-diol) measurement using an antiserum against A-diol-16-CMO-BSA is described. A-diol and testosterone (T) were determined by radioimmunoassay methods in spermatic and peripheral venous plasma of nine normal subjects during surgical intervention for inguinal hernia repair. In spermatic venous plasma the levels of T and A-diol were, respectively, 25.9 ± 13.3 and 4.8 ± 5.1 µg/100 ml (mean ± SD) with an A-diol/T ratio of 0.19 ± 0.15 (mean ± SD); in peripheral plasma the levels of T and A-diol were, respectively, 269 ± 58 and 91 ± 25 ng/l00 ml (mean ± SD) with an A-diol/T ratio of 0.35 ± 0.12 (mean ± SD) significantly different from spermatic venous plasma (p < 0.01). From these data a mean testicular A-diol secretion of about 0.70 mg/24 h can be calculated: this value corresponds approximately to the 50% of the blood production rate (BPR) of this steroid. So it can be assumed that a large amount of A-diol in systemic blood comes from sources outside th

ISSN:1663-2818    

DOI:10.1159/000178913

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Endocrine evaluation is reported in 8 acromegalic patients who received 5,500 rad to the pituitary from a linear accelerator. There was a mean decrease in hGH levels of 72%. Plasma testosterone levels were low in 1 of the 6 male patients prior to pituitary irradiation and were below normal in all male patients on the final evaluation (3.1 ± 0.2 SD years postirradiation). Deficiency of TSH secretion developed in 2 patients following irradiation. This rather high incidence of postirradiation partial hypopituitarism was not anticipated, and is thought to be related to radiation necrosis of the normal pituitary tissue which surrounds the adenoma

ISSN:1663-2818    

DOI:10.1159/000178914

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effects of drugs which interfere with α-adrenergic and dopaminergic mechanisms, involved in GH and PRL secretion, have been analyzed in urethane anesthetized rats. Clonidine induced a dose-dependent release of GH (0.0032–0.1 mg/kg i.v.) as well as of PRL (0.032–1.0 mg/kg i.v.). The lowest dose of clonidine, when given into the third ventricle, provoked a very pronounced release of GH. Phentolamine, given intravenously, inhibited the clonidine-induced GH release in a dose-dependent manner. L-Dopa administered intravenously and apomorphine administered intravenously or intraventricularly did not affect basal secretion of GH but produced a dose-dependent inhibition of clonidine-induced GH release. Pimozide did not change basal GH secretion. Furthermore pimozide did not attenuate the inhibition of clonidine-induced GH secretion seen after apomorphine administration, however, it completely reversed apomorphine-induced PRL inhibition. These findings demonstrate that an α-adrenoceptor-mediated stimulatory mechanism is involved in GH and PRL secretion. An inhibitory dopaminergic mechanism is confirmed for PRL secretion and suggested for GH secr

ISSN:1663-2818    

DOI:10.1159/000178915

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Doses of testosterone propionate from 2.5 to 320 µg and doses of LH from 2 to 360 µg given over 1–3 days generally decreased fructose/body weight ratios in the coagulating glands of late prepuberal rats. The ratios of testes, seminal vesicles, coagulating glands and ventral prostates to body weight were increased after different treatment regimes with testosterone propionate. These changes in the variables measured could be detected by computer analysis in spite of the rapid growth rates of organs of rats of this age. LH increased the weights of only the seminal vesicles and coagulating glands, and then, only at the highest doses gi

ISSN:1663-2818    

DOI:10.1159/000178916

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

A significant elevation in plasma prolactin was observed 10 min following the intravenous injection of 100 µg of melatonin into either estrogen-progesterone (EP) primed or into nonsteroid-treated male rats. 60 min postinjection in the EP-primed rat, the groups treated with 100 µg or 10 mg of melatonin had significantly elevated plasma prolactin levels while no effect was observed with these same doses in the nonsteroid-treated rats. Compared to diluent-treated controls, a significant elevation in plasma prolactin was observed at 10, 20 and 60 min following the intravenous injection of either 1 µg arginine vasotocin (AVT) or 1 mg melatonin into EP-primed male rats. A consistent rise in plasma prolactin was also evident after the injection of 1 µg of either arginine vasopressin, lysine vasopressin or AVT. Oxytocin had no effect on plasma prolactin values. The intravenous administration of 1 µg of (deamino-1,6 dicarba, 8-arginine)-vasotocin caused a significant elevation of plasma prolactin 10 and 20 min after injection. However, the injection of another analogue of AVT, (4-leucine, 8-arginine)-vasotocin, had no effect on prolactin release at the time points meas

ISSN:1663-2818    

DOI:10.1159/000178917

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000178918

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000178919

出版商:S. Karger AG    

年代:1978

数据来源: Karger