摘要:

Serum growth hormone (GH) fell and serum insulin (IRI) rose within 30 min following infusion of phentolamine, an α-adrenergic blocking agent, into the anterior hypothalamus or third ventricle of conscious, fasted baboons. GH and IRI were unchanged following intravenous infusion systemically of phentolamine at doses 2 to 4 times greater than given centrally, indicating that the reciprocal changes in GH and IRI did not result from direct action of phentolamine on the adenohypophysis and pancreatic islets. Rather, these data suggest that the phentolamine blocked hypothalamic adrenergic mechanisms participating in the normal regulation of GH and IRI. Plasma glucose and 17-OHCS rose and plasma glycerol fell in association with changes in GH and IRI, but blood pressure, heart rate and internal temperature were not altered

ISSN:1663-2818    

DOI:10.1159/000178270

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The present report concerns a child with galactosemia due to galactose-1-phosphate uridyl transferase deficiency, in whom both oral glucose and galactose tolerance tests were performed along with measurements of plasma insulin and growth hormone (GH). An oral galactose tolerance test showed an abnormally high rise and prolonged peak of the galactose curve as compared to the control. Insulin levels remained at extremely low values in both our patient and the control. GH levels showed no consistent changes in relation to blood glucose or galactose, but remained high throughout the test. GH levels showed a rise after the administration of glucose with failure of complete suppression. In the young infant, hypoglycemia may be partially prevented by hypersecretion of GH. Patients with a longer duration of untreated disease might be more prone to develop hypoglycemia.

ISSN:1663-2818    

DOI:10.1159/000178271

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Human chorionic somato-mammotropin (HCS) was injected intravenously (25 mg/kg) into hypophysectomized dogs and caused a sluggish rise in the concentration of plasma free fatty acids (FFA), which became statistically significant 2 h after administration of the hormone. When the animals were pretreated with dihydroergotamine (DHE, 0.2 mg/kg), the lipolytic effect of HCS was greatly facilitated and augmented; the rise in the concentration of plasma FFA became statistically significant already 30 min after injection of the hormone. The combined adipokinetic action of DHE-HCS was suppressible with puromycin. The results are comparable to those reported by us for the DHE-growth hormone combination, and thus provide further evidence for the intimate biological relationship between these two hormones.

ISSN:1663-2818    

DOI:10.1159/000178272

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Thyroidectomized rats present lower plasma β-glucuronidase activity than age-paired controls. A very small daily dose of L-thyroxine (0.2 µg/100 g body wt.) which reinitiated growth in thyroidectomized rats increased their plasma β-glucuronidase activity toward the values of age-paired controls. Hypothyroidism induced by different drugs decreased the plasma activity of the enzyme. Animals on KCI04 had the lowest values and were comparable to those observed in thyroidectomized rats. However rats on PTU and KSCN showed higher values than the KCIO4 treated rats, although they were lower than those of the controls. The same change to β-glucuronidase was observed in plasma insulin lev

ISSN:1663-2818    

DOI:10.1159/000178273

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

Radioisotopic exchange studies in pregnant sheep support the concept of a small but significant bidirectional transplacental thyroxine flux between mother and fetus in the last bimester. The direction and extent of this transfer is not known. There appears to be a rapid and appreciable deiodination of the administered radioactive thyroxine, but no indication that this iodide appeared to any measurable amount as radiothyroxine. The relatively small quantities of radioactive thyroxine transferred become quite significant when compared to the extremely small concentrations of free thyroxine presented to each placental interface.

ISSN:1663-2818    

DOI:10.1159/000178274

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

In order to study thyrotropin releasing hormone (TRH)-thyroid hormone interaction, we examined thyrotropin (TSH) behaviour after synthetic TRH administration in 24 euthyroid subjects, 3 patients with primary hypothyroidism and 10 hyper thyroids. 8 normal subjects were studied before and after triiodothyronine (T3) treatment with increasíng TRH dosage. Our results suggest that (1) TRH-thyroid hormone interaction is dose-related: this means that TSH response to TRH depends on both thyroid hormone and TRH concentration; (2) T3-TRH interaction on TSH release is only roughly quantitative since it is suggested that other extrathyroidal factors interfere with this mechanism controlling TSH secretion

ISSN:1663-2818    

DOI:10.1159/000178275

出版商:S. Karger AG    

年代:1972

数据来源: Karger