摘要:

Dahl ‘S’ rats become hypertensive when fed a high NaCl diet but remain normotensive on a low NaCl diet. Dahl ‘R’ rats are normotensive on either diet. For a given perfusion pressure, isolated ‘S’ kidneys excrete 50% less Na than ‘R’ kidneys. Therefore, we searched for a Na-retaining hormone in ‘S’ rats. Kidneys were isolated without ischemia from normal rats and were continuously perfused at 125 mm Hg with blood from Dahl ‘S’ and ‘R’ rats, all on low NaCl diets. Kidneys and adrenals had been extirpated from the perfusing rats. During 15 min of perfusion, the isolated ‘normal’ kidneys excreted a mean of 164 µEq of Na/min/100g during 26 perfusion experiments with blood from ‘R’ rats. The ‘normal’ kidneys excreted a mean of 84 µEq N

ISSN:1663-2818    

DOI:10.1159/000179066

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Follow-up data of a girl with 3β-hydroxysteroid dehydrogenase deficiency at a pubertal bone age are presented. On examination at age 14.7 years (bone age 12 years), there was no spontaneous breast development. On treatment with hydrocortisone and fludrocortisone, most steroids with the exception of increased 170H-ρregnenolone in plasma and △5-pregnenetriol and pregnanetriol in urine, were normal. After 1 week off hydrocortisone, plasma 170H-pregnenolone, DHA and △5-androstenediol and urinary Δ5-pregnenetriol and pregnanetriol increased markedly, while plasma 170H-progesterone increased only slightly. On increased hydrocortisone medication, there was no response of plasma estradiol to HMG. This first observation of a pubertal girl with 3β-hydroxysteroid dehydrogenase deficiency indicates that in this patient, the defect persists at a pubertal bone age and that it is not limited to the adrenals, but also affects the ovaries. Girls with this type of defect thus require estrogen replacement at a bone age of about 12 years. The large quantities of pregnanetriol in the urine are not due to an incomplete defect or an additional 21-hydroxylase deficiency, but most likely to the peripheral or hepatic conversion of 170H-pregnenolone or △5-preg

ISSN:1663-2818    

DOI:10.1159/000179067

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Luteinizing hormone-releasing hormone (LH-RH) was administered to pre-pubertal male rats (intact, castrate or castrate-adrenalectomized, 60 g body weight) for 28 days (1 µg LH-RH/day, s.c), at a 10-fold physiological dose, as compared to the minimal FSH-releasing dose of 100 ng/rat s.c. In intact rats, serum LH and weight of androgen-dependent organs (ventral prostate, seminal vesicles) were reduced after 14 days of treatment. In castrate rats, the postcastration rise in serum LH was abolished by treatment. Pituitary LH content, FSH secretion and prolactin secretion were not suppressed. Hypo-thalamic LH-RH was increased at 14 and 21 days. In castrate adrenalectomized male rats, LH secretion was also suppressed by 1 µg LH-RH s.c. × 28 days. The hypothalamic LH-RH content did not increase. The pituitary LH-RH receptor level was not down-regulated after 14 days treatment either in intact or castrate male rats. Pituitary inhibition (LH release) in rats by a supraphysiological dose of LH-RH given for 28 days indicates that the optimal regime for chronic treatment has to be determined by monitoring LH release at regular intervals. Direct pituitary inhibition by LH-RH may explain some of the unexpected antifertility effects observed with high doses of LH-

ISSN:1663-2818    

DOI:10.1159/000179068

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The 24-hour urinary excretion of cyclic AMP was determined in 102 normal boys aged 1.9-16.9 years and in 136 cryptorchids aged 2.5 – 16.9 years. A marked increase of the normal cyclic AMP excretion was found in pubertal years. There was a positive correlation between urinary excretion of cyclic AMP and the excretion of testosterone, androstenedione, LH and FSH. A positive correlation was also found between cyclic AMP excretion and height and weight, respectively. Mean cyclic AMP excretion of bilateral and unilateral cryptorchids was normal in all bone age groups except in unilateral cases with bone age 8-9.9 years and bone age ≧14 years. In these two groups, mean cyclic AMP excretion was moderately increased. After HCG stimulation of 25 cryptorchids, urinary cyclic AMP excretion varied between increased, unchanged and decreased values. The cyclic AMP excretion changes observed in some of our patients were difficult to interpret and were possibly of unspecific nature. Further information about the testicular cyclic AMP secretion and the relationship between this nucleotide and sexual hormones may be obtained from studies in testicular biopsy tis

ISSN:1663-2818    

DOI:10.1159/000179069

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The response of plasma prolactin to vigorous suckling was measured in lactating rats which had been isolated for 10-12 h from their offspring. Plasma prolactin was investigated during suckling at various stages of lactation. The results demonstrate that prolactin responds maximally to suckling already in the first days of lactation. In the second half of the lactation period, the prolactin rise in the plasma induced by suckling decreases gradually; this is not due to a reduced suck-intensity of older pups. A relationship is found between the height of the suckling-induced prolactin rise and litter size. The data suggest that during suckling in the first weeks of lactation the pituitary secretes large amounts of prolactin at a constant rate. It is speculated that in the first minutes of suckling, receptors may clear considerable amounts of released prolactin from the circulation.

ISSN:1663-2818    

DOI:10.1159/000179070

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000179071

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000179072

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000179073

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000179065

出版商:S. Karger AG    

年代:1979

数据来源: Karger