ISSN:1663-2818    

DOI:10.1159/000181097

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000181098

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Growth velocity (cm/year) was studied in 93 prepubertal children of varying height and correlated with the parameters of 24-hour growth hormone (GH) secretion: maximum peak, integrated concentration (IC), number and amplitude of peaks. The group consisted of 74 boys and 19 girls whose mean age was 10 years 8 months. Fifty-five children had growth retardation (m = -2.8 SD), 22 were of normal height between ± 2 SD and 12 had tall stature (m = 3.1 SD). Growth velocity for the group as a whole was 4.7 cm/year, 3.9 cm/year for the children with delayed growth, 4.6 cm/year for the normal children and 7.4 cm/year for the tall children. The study of 24-hour GH secretion for the group as a whole gave the following results: maximum peak 22.4 ± 13.4 ng/ml, number of peaks 4.6 ± 1.9 and IC 3.5 ± 2 ng/ml. The multiple regression test showed a significant correlation (p < 0.001) between growth velocity and the number of peaks during the night and over the 24-hour period. This correlation existed in all three groups, but was stronger in the group of tall stature than in the other two groups. However, no correlation was found between growth velocity, value of the maximum peak and integrated concentration in the group as a whole or in any of the three subgroups. These data show that the pulsatile nature of GH secretion is one of the factors most closely correlated with growth velocity, in children with growth retardation as well as in children of normal height and in tall children. On the other hand, there is no significant correlation with maximum peak and 24-hour integrated concentrat

ISSN:1663-2818    

DOI:10.1159/000181099

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Growth hormone (GH) and prolactin (PRL) responses after TRH administration were studied in 31 women presenting with the clinical, biochemical and ultrasonographic characteristics of the polycystic ovarian (PCO) syndrome; their results were compared with those of 20 normally menstruating women investigated during the early follicular phase of the cycle. Based on the GH responses two PCO subgroups were observed: (a) nonresponders (n = 16) who showed △max GH responses (0.7 ± 0.27 ng/ml, x ± SE) similar to those of the normals (0.97 ± 0.20 ng/ml), and (b) responders (n = 15), 48.4% of the PCO patients who showed a paradoxical increase in GH levels (△max GH, 18.0 ± 1.96 ng/ml) following thyrotropin-releasing hormone (TRH) administration significantly higher than those observed either in nonresponder PCO patients or in normals. Furthermore, basal GH levels were found to be significantly higher in the responder PCO subgroup (5.65 ± 0.75 ng/ml) compared to either nonresponders (1.58 ± 0.21 ng/ml) or normals (1.8 ± 0.18 ng/ml). However, no correlation was found between basal GH levels and △max GH responses observed. Additionally, basal PRL and △max PRL levels following TRH administration did not differ either between the two PCO subgroups or those observed in normal controls. Δ4A, T and E2 levels were similar between the two PCO subgroups. No correlation was found between the △max GH responses to △max PRL or the post-luteinizing hormone-releasing hormone stimulation test △max luteinizing hormone:follicle-stimulating hormone ratio observed or to steroid levels. These data are suggestive of an abnormal responsiveness of somatotrophs to TRH stimulation in 48.4% of PCO patients which could not be correlated either with an abnormality of lactotrophs or with a difference of the androgen and

ISSN:1663-2818    

DOI:10.1159/000181100

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Thirteen patients who presented with signs and symptoms of pituitary disease gave a history of classical pituitary apoplexy. Six presented with acute symptoms and in 7 the history antedated the admission by a mean of 887 days (range 365–2,190 days). All patients had an enlarged eroded sella. CT scans revealed a bleed in the tumor in 11 (histologically confirmed in all 8 patients operated), evidence of residual tumor in 1 and an empty sella (ES) in 1 patient. Hypopituitarism was present in 9, 4 were endocrinologically normal, 8 had visual problems requiring decompressive surgery and radiotherapy (RT) was given to 7 patients. They were subsequently followed for a median period of 730 days (range 365–3,385 days). During this time an empty sella developed in 5, 2 of whom had no surgery or RT; 4 remained endocrinologically normal, and a second hemorrhage occured in 2 patients. Histological evidence of previous bleeds was noted in 6 of the 8 patients treated surgically. We conclude that apoplexy (1) may produce complete or partial tumor destruction with or without preservation of endocrine function; (2) recurrent, often silent, bleeding into a pituitary tumor appears to be a common event; (3) RT should be withheld unless recurrent tumor is documented (since at least 2 patients in this study have experienced spontaneous resolution of the tumor); and (4) the presence of an enlarged eroded fossa with an ES is reasonable presumptive evidence of an infarction of a pre-existing pituitary tu

ISSN:1663-2818    

DOI:10.1159/000181101

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

In order to study the hypothesized impairment of the serotoninergic system in human obesity, an insulin tolerance test (ITT) was carried out on 12 obese normoprolactinemic women and on 6 normal-weight women before (A) and after (B) the administration of a serotoninergic drug, fenfluramine (60 mg twice a day per os for 7 days). After a washout period, a new ITT (C) followed the administration of fenfluramine at the same dose, associated with a specific S2 blocker receptor agent, ritanserin (30 mg/day for the first 2 days and 20 mg/day for a further 5 days). In obese subjects, the prolactin (PRL) response to ITT A was reduced as compared to the controls: in 6 patients (‘nonresponders’) the PRL levels did not change, while in the other 6 (‘responders’) they increased (p < 0.003) but less than in the controls (p < 0.02). In normal-weight subjects, the administration of fenfluramine alone or with ritanserin did not modify the PRL response to ITT. In the responders, the serotoninergic drug normalized the PRL response to ITT while significantly improving it in the nonresponders; these effects were not antagonized by ritanserin. In conclusion, our data suggest that the serotoninergic system of obese patients is impaired and that the different secretory pattern observed in the two groups before and after fenfluramine may reflect differing degrees of this imp

ISSN:1663-2818    

DOI:10.1159/000181102

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Recombinant human insulin-like growth factor I (IGF-I) was injected daily (4 or 8 mg/pig) as an intra-arterial bolus into pigs for 3 consecutive days and the serum IGF-I concentration was measured to determine disappearance profiles. IGF-I partitioned to a fast component (half-life, t½ = 5.7 min) and a slow component (t½ = 253 min) in pig serum. Chromatography of serum revealed that the fast component comprised unbound IGF-I, whereas the slow component comprised IGF-I bound to 40- and 150-kD serum IGF-binding proteins. In addition, administration of exogenous IGF-I caused significant hypoglycemi

ISSN:1663-2818    

DOI:10.1159/000181103

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Testosterone is known to increase epidermal growth factor (EGF) concentrations in mouse plasma and submandibular salivary gland. We tested in adult sialoadenectomized (sx) and sham-operated female and male mice our hypothesis that female sex steroids also affect EGF concentrations in fluids and tissues. In 10-day treatment estradiol-17β increased the EGF concentration in male urine and in (sx) female plasma. Progesterone increased the concentration in both sexes in plasma (sx mice) and in the kidneys. In contrast, progesterone decreased it in female urine

ISSN:1663-2818    

DOI:10.1159/000181104

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1663-2818    

DOI:10.1159/000181105

出版商:S. Karger AG    

年代:1989

数据来源: Karger