ISSN:0300-9742    

DOI:10.3109/03009748009098153

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

The case histories of an unrelated husband and wife in whom polymyalgia rheumatica developed within one month are described. In the wife, giant-cell arteritis was present. The clinical courses were similar and there was a typical good response to treatment with prednisone. Both patients were HLA-B8. Only the husband had positive hepatitis-Bsantibody. The aetiology of the disease is discussed in relation to tissue antigens and hepatitis-B infection.

ISSN:0300-9742    

DOI:10.3109/03009748009098154

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Purified human granulocyte collagenase (1 mg%, 10 mg% or 50 mg%) was injected into rabbit knee joints (three groups of 6 animals each) three times within one week. Synovium and synovial fluid were investigated 18 hours, 1 week and 3 weeks after the last injection. After 18 hours, synovial fluids showed distinct cellular exudation, its size depending on the amount of collagenase applied. A smaller number of cells was seen after one week, while normal cell counts were observed 3 weeks after the last injection. Histologically, synovium showed an acute arthritis after 18 hours, whereas after 1 and 3 weeks a chronic proliferative form of arthritis with predominant activation of fibroblasts was diagnosed. As compared with an experimental arthritis induced with rheumatoid synovial collagenase, granulocyte collagenase was less arthritogenic. Neither trypsin nor saline injections induced distinct cellular exudation into synovial fluids nor histologic signs of arthritis.

ISSN:0300-9742    

DOI:10.3109/03009748009098155

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

This work describes four patients with poly myalgia arteritica (PMA) and one patient with an illness compatible with PMA within one family. Of these 5 patients, 4 are siblings while one is a genetically unrelated husband. The husband had a classical GCA in 1969. Over a period of one year starting in 1975, the husband's wife and three of her siblings were affected with PMA. This observation is highly suggestive of an infectious agent as being responsible for PMA, and a genetic disposition is probably essential for development of the disease. The incubation period is probably in the range of 5–7 years.

ISSN:0300-9742    

DOI:10.3109/03009748009098156

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

ISSN:0300-9742    

DOI:10.3109/03009748009098157

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor