摘要:

Yersinia enterocolitica (Y. ent.) infections are rather frequently complicated by acute reactive inflammation in the connective tissue, especially in the joints. At this stage of the disease the specific diagnosis can be obtained either by bacterial isolation and identification from the feces and/or mesenterial lymph nodes, or by serological methods. Serodiagnostics are frequently the only method during the complication phase, since the bacteria have often disappeared from the feces by this stage of the disease. Specific Y. ent. Serodiagnostics are benefitted by the fact that no antisera cross-react with the serotype 3 thermostable O-antigen. A titre of≥80 is therefore highly indicative of a recent or current Y. ent. infection. In the absence of other known arthritogenic agents the Y. ent. antibodies are highly indicative of the Y. ent. etiology of a current disease. The Y. ent. complications affect most inflammatory reactive diseases, acute as well as chronic. In an area in which Y. ent. infections are endemic, Y. ent. is the most frequent cause of acute and chronic arthritis. The present results indicate that not all cases of acute Y. ent. arthritis remit, but some persist, usually with an intermittent course, and develop into rheumatoid arthritis or allied conditions. This suggests a common pathogenic mechanism in most inflammatory rheumatic diseases. It is proposed that the time has come for a classification of these diseases based on their etiology, in order to replace the present symptom-based treatment with a causal one, and to institute prophylactic measures. The pathology is not exclusive to Y. ent., but can presumably also be brought about by other bacteria, such as gonococci, meningococci, salmonellae, shigellae, and brucellae, possibly by their content of lipopolysaccharide.

ISSN:0300-9742    

DOI:10.3109/03009748009098143

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Two (7%) out of 29 patients with chronic prostatitis were HLA B27 positive. They had roentgenological normal sacro-iliac joints. Two (7%) had sacro-iliitis as judged by radiological examination; one of them had never experienced low back pain. No patient had arthropathy in peripheral joints, ulcerative colitis, Crohn's disease, psoriasis or anterior uveitis. It was concluded that ankylosing spondylitis is rare in patients treated for chronic prostatitis.

ISSN:0300-9742    

DOI:10.3109/03009748009098144

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

The right knee of adult rabbits was immobilized in extension for 5 weeks. The rabbits were then allowed to move freely for 8 weeks. Some rabbits were given 100 mg of ibuprofen (Brufen®) dailyper osduring the immobilization and remobilization periods. The controls were not given any drug. The development of the thickness, stiffness and degenerative changes in the knees as a result of immobilization was observed. The thickening was significantly less and the radiological changes were significantly smaller in the knees of those rabbits given ibuoprofen than in the controls. There were no significant differences between the groups regarding the mobility of the immobilized knees. In the study the anti-inflammatory drug ibuprofen had a prophylactic effect on some of the pathological processes in the rabbit knee (following immobilization and resulting in progressive osteoarthritis.

ISSN:0300-9742    

DOI:10.3109/03009748009098145

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

The causes of death of 79 patients with ankylosing spondylitis (AS) diagnosed between 1952 and 1959 were investigated. The basic cause of death was a cardiovascular disease in 35.4% of the patients, AS in 29.1 %, violent death in 10.1%, malignancy in 8.9%, gastrointestinal diseases in 6.3%, pulmonary tuberculosis in 2.5%, urogenital diseases in 2.5%, respiratory diseases in 3.8% and diabetes mellitus in 1.3%. Only one patient had a lymphoma and another patient chronic lymphatic leukaemia despite the X-ray therapy that almost every patient received. The immediate cause of death was uraemia caused by renal amyloidosis in 18% of the cases. In addition, uraemia from renal amyloidosis was part of the basic cause of death or a contributory factor in 3.8%. Thus, uraemia caused by renal amyloidosis in one way or another affected the cause of death in 21.5% of the cases. This figure is considerably higher than those given in earlier works.

ISSN:0300-9742    

DOI:10.3109/03009748009098146

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

The effect of indomethacin on bone resorption was studied in an organ culture system, using calvarial bones from 6–7-day-old mice. It was found that indomethacin inhibited spontaneous bone resorption, as estimated by decreased release of45Ca, Ca2+and P,. Indomethacin reduced the release ofβ-glucuronidase,β-galactosidase andβ-N-acetylglucosaminidase, diminished glucose consumption and lactate production, but showed no effect on the release of lactate dehydrogenase. No inhibitory effect of indomethacin on the release of45Ca stimulated by parathyroid hormone, prostaglandin E2or 1α(OH)D3could be registered. 5,8,11,14-eicosatetraynoic acid, an inhibitor of both cyclo- and lipoxygenase pathway of arachidonate metabolism, reduced the spontaneous release of45Ca, whereas the selective lipoxygenase inhibitor 5,8,11-eicosatriynoic acid was without effect. The results presented indicate that indomethacin may have an inhibitory effect upon the osteoclasts, probably by decreased metabolism of arachidonic acid via the cyclo-oxygenase pathway. A possible relationship between this rinding and the pathogenesis of rapid destruction of articular bone in osteoarthritic patients treated with indomethacin is discussed.

ISSN:0300-9742    

DOI:10.3109/03009748009098147

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

In order to study interactions in vivo between Au+and SH-containing agents, groups of mice were given 35μmol/kg of radiolabelled [195Au] thiomalate (Myocrisin) intramuscularly. The administration of Myocrisin is known to result in protein-bound gold and free thiomalate (mercaptosuccinate). High doses of dimercaptosuccinate (1 mmol/kg daily) increased the urinary excretion of radiolabelled gold [195Au] for several days. Treatment for 7 days with 1 mmol/kg of penicillamine or dimercaptosuccinate reduced the blood and kidney levels of gold to 30–50% of the controls. The oral administration of penicillamine in high doses, 1–10 mmol/kg, increased significantly the urinary excretion of [195Au] the first day after the Myocrisin injection, but on the subsequent days the radio-metal excretion was unaffected by the treatment. A lower dose level of penicillamine (0.3 mmol/kg daily) gave rise to only a small and insignificant increase in the urinary excretion of gold. The present results indicate that penicillamine at low clinical doses is an inefficient chelator of gold, while high doses (presumably comparable to about 1200 mg daily in humans) may mobilize certain amounts of the metal deposits.

ISSN:0300-9742    

DOI:10.3109/03009748009098148

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

The effects of a commonly used non-steroid anti-inflammatory drug (naproxen) on zinc metabolism was studied in healthy volunteers. A significant increase in the urinary zinc excretion rate was found during treatment with naproxen, with a mean increase in the order of 35%. At the end of the treatment period the urinary zinc excretion fell towards normal, and after withdrawal of naproxen the urinary excretion rate became normal. During the treatment period the serum zinc concentration was virtually unchanged, being comparable to the initial and post-treatment values. The mechanism by which naproxen induces hyperzincuria is not known. Protein binding interaction or a direct renal action of naproxen implying a decrease in the maximum tubular reabsorption capacity (Tmax) would lead to an increase in zinc excretion. Prolonged studies in patients with rheumatoid arthritis, both untreated and treated with prostaglandin inhibitors, are needed however in order to evaluate the possibility of a zinc depletion.

ISSN:0300-9742    

DOI:10.3109/03009748009098149

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Synovial fluid from the inflamed knee joints of 30 patients with rheumatoid arthritis (RA) contained 2.75±0.81 mmol/1 cholesterol (51% of the corresponding mean serum level) and 0.32±0.13 mmol/1 triglycerides (35% of the corresponding mean serum level). The ratio of synovial fluid triglycerides to cholesterol indicates that in RA the concentration of very low density lipoproteins (VLDL) is lower in synovial fluid than in serum. In a few patients, however, the“relative triglyceride concentration”in synovial fluid (i.e. synovial fluid tg/chol: serum tg/chol) was greater than 1. This concentration did not correlate, moreover, with the clinical activity of the disease.

ISSN:0300-9742    

DOI:10.3109/03009748009098150

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Sixty adult male rats were used to study the effect of the anti-inflammatory drug Ibuprofen on fracture callus and perpendicular skeleton. After experimental periods of 3 and 9 weeks, fracture callus and both fractured and unfractured tibiae were examined with respect to bone mass and composition and45Ca metabolism. No significant changes were found in the composition of fracture callus during treatment. Significantly diminished parameters of both fractured and unfractured tibia were observed for wet and dry weights, ash content, and organic matter after 3 weeks but the bone mass had become almost restored and the changes were non-significant during treatment 9 weeks following fracturing. The45Ca activity was elevated significantly in fracture callus and fractured tibia 3 weeks after fracturing but had definitely declined to physiological levels at 9 weeks. Serum45Ca activity was significantly elevated during Ibuprofen treatment. The findings support the concept that Ibuprofen lessens the bone mass and composition of both fractured and unfractured tibia and also activates the calcium metabolism in fracture callus. In the long run, however, this effect is weakened and the bone changes are become almost normal. Some explanations regarding these short-term effects of Ibuprofen are discussed.

ISSN:0300-9742    

DOI:10.3109/03009748009098151

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Pigmented villonodular synovitis (PVS) was diagnosed in 25 patients during the period 1950–76. Twenty-two of the patients were re-examined 2–28 years later. Three patients with local affection of tendon sheaths, treated by excision, were all free of symptoms at follow-up. Nineteen patients all with unilateral knee joint affection were divided into two groups according to peroperative findings, 6 localized PVS and 13 diffuse PVS. The 6 patients with localized PVS all had normal knee movement at follow-up, whereas the 13 with diffuse involvement had varying impaired knee mobility.

ISSN:0300-9742    

DOI:10.3109/03009748009098152

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor