ISSN:0300-9742    

DOI:10.3109/03009748009112346

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

A postal questionnaire designed to assess joint laxity was sent to 364 specialist female teachers of physical education who had participated in a radiological survey on the lumbar spine. 295 replied and in this group the prevalence of spondylolisthesis was 4%. Although statistical analysis failed to demonstrate a significant association between generalized joint laxity, measured with a simple scoring system, and radiological spondylolisthesis, spondylolisthesis was found to correlate with known associations of joint laxity such as flat feet. Adults with spondylolisthesis considered themselves more supple in youth than adults without spondylolisthesis.

ISSN:0300-9742    

DOI:10.3109/03009748009112347

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

A 62-year-old man with classical signs of polymyalgia rheumatica for one year suddenly developed fatal renal failure, despite treatment with steroids. Autopsy showed disseminated giant cell arteritis in the kidneys, pancreas, oesophagus, and larynx, with the most pronounced changes in the kidneys. All intrarenal arteries and arterioles were affected. The changes ranged from occlusive intimal proliferation to severe fibrinoid necrosis in the whole arterial wall. Fibrinoid necrosis was also found in the afferent and efferent arteries and several thromboses were seen in the glomeruli. It is not known why this apparently non-complicated case of polymyalgia rheumatica suddenly turned into a fatal case of disseminated giant cell arteritis. The only precipitating factor to be incriminated seems to be a reduction in the corticosteroid dose. This case adds further support to suggestions of the existence of a distinct type of systemic giant cell arteritis.

ISSN:0300-9742    

DOI:10.3109/03009748009112348

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Platelet survival studies were carried out on 36 patients suffering form SLE. Twelve of them received no therapy, 17 were on corticosteroids (CS), and the remaining 7 received CS and azathioprin (AT). Ten healthy hospital eployees served as controls. Only 1 of our SLE patients had thrombocytopenia (platelet count 42×109/l). All the remaining 35 patients had venous platelet counts≥120×108/l. In the control group the average platelet mean life-span (MLS) was 5.8±0.3 (range 4.0–6.8) days. In the group of untreated SLE patients 3 out of 12 subjects (25%) had a platelet MLS below the lower range for the controls. The mean platelet MLS in the control group did not differ statistically from any of the means of the three groups of SLE patients studied. The lowest mean for platelet MLS (5.2±0.6 days) was encountered in the group of patients who received no therapy. The means for platelet MLS in the two groups of SLE patients who received immunosuppressive therapy were higher (6.5±0.4 and 6.6±0.4 days, respectively) but did not differ statistically from the mean of untreated patients (0.10>p>0.05). The mean platelet production rate in the control group (23×1010platelets per day) did not differ from any of the three groups of SLE patients investigated. In the literature it has been proposed that a state of compensated thrombocytolysis is present in most cases of SLE. The results of the present study do not support this hypothesis, however.

ISSN:0300-9742    

DOI:10.3109/03009748009112349

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

When patients with rheumatoid arthritis develop rapidly growing tumours around the hip or elbow joint, the possibility should be considered that this condition could be pseudocystic with a low virulent infection. The present report describes such a case of anaerobic bacterial coxitis with rapidly growing tumour.

ISSN:0300-9742    

DOI:10.3109/03009748009112350

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Twenty-one consecutive patients (14 women and 7 men aged 35–68 years, mean age 50 years) with chronic active RA for 2–24 years (mean 12.7 years) had a normal glomerular filtration rate (GFR) (mean value 99.8%±14.8% (S.D.) of sex- and age-dependent normal value) before penicillamine treatment. All patients had previously been undergoing gold treatment; no patient had signs of renal disorder, or diabetes. GFR (total51Cr-EDTA plasma clearance) was measured before and after 3 and 6 months' penicillamine treatment, respectively. Treatment was stopped because of side effects in 4 patients, including one with renal side effects. In the remaining 17 patients there was a mean fall in GFR of 3.8±12.5 (S.D.) ml/min during 6 months' penicillamine treatment, which was not significant. There was no correlation between individual changes in GFR and penicillamine dose. The individual changes in GFR correlated well to individual changes in plasma creatinine. Repeated determinations of plasma creatinine should be done during penicillamine treatment.

ISSN:0300-9742    

DOI:10.3109/03009748009112351

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Six months of haloperidol treatment significantly increased the serum sulfhydryl (SH) levels in all 12 rheumatoid arthritis (RA) patients studied and significantly decreased the PIP joints technetium index (Tc-index), erythrocyte sedimentation rate (ESR) and joint count. These findings suggest a specific antirheumatic activity of haloperidol in the RA patients.

ISSN:0300-9742    

DOI:10.3109/03009748009112352

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Cyclic adenosine-3, 5-monophosphate (cAMP) may influence important mechanisms in the inflammatory process, and fasting has been claimed to be clinically beneficial in rheumatoid arthritis (RA). A study was therefore designed to measure the concentrations of plasma cAMP in RA patients not undergoing drug treatment during a control and a fasting period. Twelve female RA patients were hospitalized for two 14-day periods and investigated in a crossover study. Clinical and laboratory variables of inflammatory activity were assessed during both periods. During the control period the concentrations of cAMP in plasma were slightly below the lower normal limit, with no significant change throughout the period. The clinical and laboratory variables of inflammatory activity were unchanged during the same period. In the fasting period, the prefasting level of plasma cAMP was significantly higher than on the corresponding day in the control period. During 7 days of total fasting the plasma cAMP concentrations decreased significantly. The clinical and laboratory variables of inflammatory activity decreased significantly from the start to the end of fasting. High prefasting plasma cAMP concentrations were associated with improvement in clinical inflammatory activity. A decrease in plasma cAMP concentrations during fasting in RA patients is in contrast to the findings in obese and healthy subjects previously reported.

ISSN:0300-9742    

DOI:10.3109/03009748009112353

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Thirty-four consecutively admitted patients with acute anterior uveitis (AAU) were examined. The male to female ratio was 1.8: 1. Twenty-two patients (67%) were HLA B27 positive. Twelve (36%) had radiographical sacro-iliits; all were males and were HLA B27 positive. Three of them were asymptomatic. Eighteen patients (53%) had low back pain suggestive of sacro-iliitis, but this symptom was associated neither with radiographical sacro-iliitis nor with HLA B27. Radiographical sacro-iliitis and HLA B27 occurred together more frequently in males than in females. It was concluded that the association between AAU and signs of joint affection reflects the association seen in HLA B27 positive patients, while HLA B27 negative patients suffered from low back pain as well. HLA B27 positive patients with AAU should be remitted for radiographical examination of the sacro-iliac joints.

ISSN:0300-9742    

DOI:10.3109/03009748009112354

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor

摘要:

Six months' cyclophosphamide treatment significantly increased the sulfhydryl (SH) serum levels in all 12 rheumatoid arthritis (RA) patients studied and significantly decreased the PIP joints' technetium index (Tc-index), the erythrocyte sedimentation rate (ESR), and the joint count.

ISSN:0300-9742    

DOI:10.3109/03009748009112355

出版商:Taylor&Francis    

年代:1980

数据来源: Taylor