摘要:

Abstract:Sections of temporal and occipital cortex from 14 patients with Alzheimer's disease were examined by light and electron microscopy. Especially, areas without senile plaques or neurofibrillary degeneration were examined in detail. The initial change in the cerebral cortex occurred in the capillaries. The endothelial cells demonstrated degeneration with hypertrophic distorted basement membranes and swelling of the vascular feet. Lipochromes were found in the processes and cell bodies of the astrocytes. A decrease in the number of nerve cells and their processes noted in the cortices may be due to primary vascular degeneration. Severe dementia in Alzheimer's disease may be related to the histopathological findings of diffusely destroyed nerve cells and their processes.

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1991.tb00509.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract:The subjects used in the present study consisted of 8 cases with Alzheimer's disease. Senile plaques which seemed to have no relation with the capillaries were examined in thick serial sections (3,000–5,000 A) by electron microscope. The results obtained were as follows: All of those senile plaques had amyloid angiopathy with amyloid fibrils and these amyloid fibrils formed the main elements of senile plaques. From these findings, it was confirmed that the amyloid fibrils in all plaques are produced from the capillarie

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1991.tb00510.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract:Neurofibrillary tangles (NFT) in the brains of patients with Alzheimer's disease were examined by means of tilt‐stage electron microscopy. Observing a longitudinal direction, constricted parts of the NFT did not move in an axial direction. In a transverse section, a fibril of the NFT consisted of globular subunits having a hollow structure in the center and did not appear as paired filaments. From these findings, it was considered that a fibril of NFT consists of twisted protofilaments made up of globular subunits and does not consist of paired helical filament

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1991.tb00511.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Abstract:Rat brain S‐HT2and dopamine2receptors were assessed following a chronic (3 weeks) administration of verapamil, lithium, and a combination of these two drugs. A significant increase in the number of 5‐HT2 receptors was observed in the frontal cortex after the verapamil treatment, but the lithium and combined treatment had no effect on the densities of either binding sites. These data suggest that one or more of the mechanisms of the antimanic effect of verapamil may be involved in the change in 5‐HT2binding sites in a manner that is different from that of li

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1991.tb00512.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1991.tb00513.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1991.tb00514.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY