摘要:

Abstract:An EEG frequency analysis using the wave‐form recognition method was performed in different stages of senile dementia (SD), evaluated according to the Hasegawa Dementia Rating Scale (HDS), and the differences in EEG changes between patients with Alzheimer's disease (AD) and patients with SD were studied.We found that the EEG changes in the SD patients correlated with HDS, and that an increase in slow theta (4–5.8 Hz) and a decrease in fast theta (7–7.8 Hz) waves were early changes in the SD patients.Furthermore, delta and slow theta waves increased mainly in the anterior frontal and temporal areas in the severe SD patients.The AD patients showed more severe EEG abnormalities than the SD patients and showed severe focal abnormalities in the temporal

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00446.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Abstract:The forced running stress in male rats induced some fine structural changes in the arcuate nucleus. By inducing stress for 2 days, the number of multilamellar astrocytic wrappings and endoplasmic reticular (ER) whorls increased significantly. After a stress of 12 days, half of the rats remained inactive for several weeks, and the other half regained their normal activity. In the inactive group, the ER whorls were partially degenerated at 2 weeks after the stress. These degenerative changes remained for 14 weeks after the stress with the increased lysosomes and the disorganization of r‐ER. These findings may suggest that long‐term stress induces degenerative changes in the arcuate nucleus neurons and that some of these changes persist with some aging‐like morphological ch

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00447.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Abstract:The effect of estrogen on the sleep‐wakefulness circadian rhythm was examined in ovariectomized rats. Implantation of crystalline estradiol benzoate (EB) into the third cerebral ventricle reduced the slow wave sleep (SWS) and paradoxical sleep (PS) appearances within the dark period. This result was similar to that obtained by a systemic administration of 20 μg of EB. The inhibition of sleep during the nighttime was more remarkable in PS than in SWS. The reduction of SWS was due to a shorter duration of SWS episodes and the reduction of PS to a fewer number of PS episodes. These results indicate that ovariectomized rats treated with estrogen develop an inability to sustain episodes of SWS and initiate PS episod

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00448.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

SummaryThe summary of the above results is demonstrated in Fig. 1. Li enhanced 5‐HT synthesis and 5‐HT release via its inhibitory effect on presynaptic 5‐HT autoreceptors. The increased 5‐HT level in synaptic cleft down‐regulated 5‐HT1Aand 5‐HT., receptors. The 5‐HT1A‐me‐diated AC activity and behaviors were enhanced, but the 5‐HT2‐mediated PI turnover and behaviors were suppressed. These effects of Li on 5‐HT neurones might be involved in the mechanism of acti

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00449.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00450.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00451.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00452.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00453.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00454.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1990.tb00455.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY