摘要:

Abstract:Among 53 delirious patients with an electrolyte imbalance in the serum, the duration of delirium in 18 cases was significantly shortened by the correction of electrolyte imbalance, compared with that of 35 cases of delirium without an electrolyte correction. The mean duration of delirium (mean value ± SE) corrected by electrolyte was 9.4 ± 1.9 days, whereas the mean duration of delirium without the electrolyte correction was 25.7 ± 4.6 days. The mean duration of delirium in 13 cases without the electrolyte imbalance was 25.0 ± 6.6 days. From these results, the electrolyte correction should be done systematically for the delirious patients as a treatment for the disor

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1988.tb01959.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract:Here is a report of three cases of dellvery from women who have taken sodium valproate (VPA). One neonate was born with polydactylism, and we reviewed the congenital malformations in children of mothers who have taken VPA. In the other two cases, we also examined the levels of VPA in the cord serum and breast milk. The levels of VPA in the cord serum were 50 μg/ml at 12 hours after the last maternal dose and 75 μg/ml at 14 hours after the last maternal dose. The blood levels of VPA in the two mothers were 48–59 μg/ml and 55–85 μg/ml in their late pregnancy, respectively. The levels of VPA in the breast milk were 2.0–3.5 μg/ml and the ratio of VPA in the breast milk to blood was 2–3%. These results suggest the high rate of placental transfer and the low rate of milk tra

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1988.tb01960.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Abstract:The relationship between clomipramine (CMP) brain concentration and its inhibitory effect on serotonin (5HT) turnover was investigated in rats treated with a single dose and multiple doses of CMP. CMP reduced the 5‐hydroxyindole acetic acid (5HIAA) brain levels in two groups of rats. Concerning the 5HT turnover measured by the probenecid (PBC) technique, there were significant correlations between the CMP brain level (x) and 5HIAA brain level (y) after PBC injections in both acute and chronic experiments. The regression lines for the respective groups were y = 764 ‐ 117 log x (r = 0.84, P<0.001) and y ‐ 770 ‐ 97.7 log x (r ‐ 0.68, P<0.001). The regression coefficient for the acute experiment was greater than that for the chronic one (p<0.001), indicating a less dose‐response in the latter. From these findings, the acute dosing with CMP seemed to reduce the 5HT turnover without reference to the dose but a prolonged administration seemed to vary in its effect. This may be due to a compensatory mechanism in the 5HT system induced by chronic CM

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1988.tb01961.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1988.tb01962.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1988.tb01963.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1988.tb01964.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY