摘要:

Abstract:The effect of age on resting‐state cerebral blood flow (CBF) was studied in 40 medicated patients with chronic schizophrenia aged 20 to 57 and 32 age‐ and sex‐matched normal Controls, using the regional CBF with the xenon‐133 inhalation technique. Global CBF (average of 16 cerebral regions) and the left prefrontal flow ratio (left prefrontal/global CBF) were significantly lower in schizophrenics aged 20–29 than in age‐matched controls. Both global CBF and the left prefrontal flow ratio correlated with age in controls, but neither of such correlations was found in schizophrenics. Therefore, the CBF deficits in chronic schizophrenia appear to be unaffected by the ag

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00825.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:An all‐night polysomnogram was twice recorded in a patient with neuroleptk‐induced akathisia (NIA). The polysomnogram revealed nocturnal myoclonus. After disappearance of akathisia by the administration of clonazepam, we recorded the second polysomnogram. At the second examination, sleep efficacy increased and the total number of nocturnal myoclonus decreased remarkably. The mean inter‐movement interval of nocturnal myoclonus prolonged. These findings suggest a close relationship between the mechmisms of neuroleptic‐induced akathisia and nocturnal my

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00826.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:Clinical responses to different kinds of neuroleptics in fresh schizophrenics were prospectively investigated. The scales used were the Globd Assessment Scale (GAS), Brief Psychiatric Rating Scale (BPRS) and Psychiatric Evaluation Scale (PES). The 48 subjects were classified into three groups, 16 in the phenothiazine response group, 19 in the butyrophenone response group and 13 in the nonresponse group. For the schizophrenics who displayed negative symptoms such as motor retardation and blunted affect, while displnying milder positive symptoms, phenothiazine drugs were effective, Contrarily, for the schizophrenics who displayed severe positive symptoms such as hallucination and delusion while displaying milder negative symptoms, butyrophenone drugs were effective. Large dosages of the drug did not enhance the curative effect in most cases.

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00827.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:We examined the Linkage between schizophrenia and DNA markers on chromosome 11 in two Japanese pedigrees. Thirty individuals from the two pedigrees were genotyped at the eleven polymorphisms (eight loci) studied. Data were analysed according to three models, representing a range of single gene models from near dominant to an intermediate model. For all markers, except those at the D11S35 locus, there is no evidence for the linkage. Positive LOD scores between 1 and 1.5 are obtained for some genetic models with the polymorphism at D11S35. Two point scores for the broad diagnostic model and for the intermediate parameter set peak at 1.49.

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00828.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:One hundred twenty‐nine schizophrenic inpatients who were administered zotepine were studied to see if they had zotepine‐induced convulsive seizures. Twenty‐two patients had grand mal seizures during the administration periods. The incidence of the seizure was 17.1%and was higher than that in previous reports. The average duration of zotepine administration before the seizure was 48.3 days. The incidence of the seizure was closely related to the daily dosage of zotepine, but there was no significant correlation between the daily dosage of zotepine and the duration of administration before the onset of the seizure. The patients who received a combined administration with the higher dose of zotepine and other phenothiazines were revealed to be more likely to have the seizure. In addition, young pateints and patients with a past history of head injuries showed a high incidence of the seizure with the administration of zot

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00829.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:The SHT‐induced shape change (SHT‐SC) of blood platelets, which had been suggested to reflect the SHTs receptor‐mediated function of the central nervous system (CNS), was examined in patients with depression before or after antidepressant therapy. The degree of SHT‐SC did not differ between patients before treatment (n = 17) and healthy controls (n = 26). In patients after treatment (n = 12), in whom depression had been improved but drug therapy was continued, SHT‐SC in a concentration of 10–5 M SHT was observed more potently than that in healthy controls or untreated patients (p<0.05 and p<0.05, respectively). In 4 patients in whom SHT‐SC was measured before and after mianserin treatment, SHT‐SC increased after the treatment. These results suggest that the SHT2receptor‐mediated function in the CNS may not be demaged in patients with depression, and that the 5HT2receptor‐mediated function in the CNS may be enhanced

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00830.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:We conducted serial EEG and SPECT studies on one female with Creutz‐feldt‐Jakob disease (CJD). In an analysis of EEG, a periodic synclmnons discharge WD) was observed in the middle of the third stage (terminal stage) of Bernonlli's classification. “he frequency of PSD was the highest at the begiMing of the third stage, followed by a gradual decrease and disappeared at the end of the third stage. In the middle of the third stage, SPECT disclosed blood flow differences between the cerebrum and other regions (the cerebellum amd the brainstem), while no such difference was observed by SPECT at the end of the third stage. It was snggested that the appearance of PSD requires the presence of a pathological change in the cerebrum precedent to other re

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00831.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:A micturitional history of unselected 110 patients with Parkinson's disease revealed that 66 (60%) had urinary symptoms such as irritative in 28%, obstructive in 11%, and both symptoms in 21%. The frequency of urinary symptoms statistically correlated with severity of the disease, but not with the duration of illness and no sexual difference was noted. A urodynamic study was conducted in 39 patients and 7 had residual urine of 30 ml or more, 19 had detrusor hyperreflexia, 19 had a small bladder capacity and only 1 had detrusor‐sphincter dyssynergia. The results indicate that the disturbed urine storage is more frequent and to a severer degree than that of urine evacuation in Parkinson's diseas

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00832.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:Rats were exposed to forced‐running stress for 1 day, 3 days or a long term (approximately 2 weeks), and P‐adrenergic receptor binding was then assayed using [3H]dihydroalprenoloI (DHA) in six brain regions and the liver. In the pons + med.obl., hypothalamus and midbrain, a reduction in Fadrenergic receptor density was first evident on day 1. In contrast, a decrease in Fadrenergic receptor density in the cerebral cortex and hippocampus was first evident on day 3. Decreased [3H]DHA binding in the pons + med.obl., cerebral cortex and hippocampus subsequently plateaued for the duration of the forced‐running stress. In the midbrain and hypothalamus, however, decreased [3H]DHA binding subsequently returned to control levels despite the exposure to the forced‐running stress. In the cerebellum and the liver, [3H]DHA binding did not change significantly throughout the stress. These results indicate that the forced‐running stress induces both the time‐ and region‐specific changes in Fadrenergic receptors. Moreover, the rats showed either a behavioral depression or a spontaneous recovery of running activity during the 2 weeks following the end of the long‐term stress. Thus, we also examined the relationship of P‐adrenergic receptors to these behavioral differences. [3H]DHA binding for the behavioral depression group was lower in the hippocampus and higher in the liver than for the spontaneo

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00833.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Abstract:Emerging evidences have suggested that the brain serotonin (5‐hydroxy‐tryptamine, 5‐HT) neurotransmitter system is involved in the compulsive alcohol‐seeking behaviors in humans and animal models. The aim of this study is to examine the effect of ipsapirone, which is a specific 5‐HT1A, agonist with a pyrimidinylpiperazine structure, on alcohol consumption in mice (C57BL/6J) by a voluntary alcohol intake paradigm. When the consumed 8, kohol was expressed as g/kg B.W., the total 12‐day amount was significmtly lower in the ipsapirone‐treated mice than in the saline‐treated mice. However, 5‐HT1Areceptor binding sites labeled with [3H]8‐OH‐DPAT in hippocampal membranes did not differ significantly in either the total number of binding sites (Bmax) or dissociation constant (Kd) between the two groups. The possible mechanism regarding the role of ipsapirone that attenuated the alcohol consumption, and its relationship to the subtyping 5‐HT receptor

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1992.tb00834.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY