摘要:

SummaryPsychiatric and socio‐psychiatric problems of 1,388 narcotic addicts discharged during a 4 year period (January 1, 1966‐December 31, 1969) from Seoul Municipal Mental Hospital are investigated and discussed.1) The number of narcotic addicts is decreasing year by year. Admission rates are thus decreasing rapidly. On the contrary, there is a prominent tendency of transition from narcotic addicts to non‐narcotic, habit‐forming drug users.2) Only 0.73% are teenagers and average ages of the addicts are 42.88 in males and 35.73 in females. There is a preponderance in the middle age group. New addicts are few and repetitively readmitted cases are usual.3) Pure narcotic addicts are 28.94%, non‐narcotic, habit‐forming drug users are 26.94%, and mixed users are 31.56%. In 1969, narcotic addicts and mixed users decreased to 11.38% and 12.19% respectively. Non‐narcotic drug users increased to 54.48%. Among the narcotic drugs, heroin is the most frequently used, while barbiturates and meprobamate are most frequent among the non‐narcotic drugs. Narcotic drugs are mostly purchased in smuggling dens and non‐narcotic drugs are easily bought at drugstores. Abstinence syndromes were mild.4) Characteristic findings in addicts were irregular and distorted marital life, poor economic status and criminal occupations.5) Psychological conflicts were 68.90% of various motives of the first episodes. Among them interpersonal conflicts were most important. 72.98% became addicted during the course of self‐treatment of physical illness. In such cases, narcotic drugs were used as omnipotent drugs.6) A characteristic psychopathological feature of Korean narcotic addicts was that they became addicted during the course of treatment of physical illness or psychological instability, rather than as a manif

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1972.tb01117.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SummaryAn autopsy case was presented of brain stem encephalitis diagnosed clinically. A patient was taken ill with headache and double vision. He developed character change, dysphagia, dysarthria, nuchal rigidity and spastic quadriparesis with intermittent fever, following the disappearance of double vision. These symptoms and signs progressed slowly with transient remissions. He died at the age of thirty‐five years, three years and six months after the onset. On neuropathological examination, there were chronic inflammatory lesions together with demyelination and gliosis in the hypothalamus, lower end of the internal capsule, optic chiasm, midbrain, pons, medulla oblongata and spinal cord. The clinicopathological features of our case were most similar to those of brain stem encephalitis described by Iizuka. However, the spinal cord involvement was severe in our case. Viral studies examined were all negative, despite that the neuropathological findings were suggestive of some viral infectio

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1972.tb01118.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SummaryL‐Dopa was administered to 84 cases of schizophrenia (55 male, 29 female) together with major tranquilizers which had been given previously.1) Patients suffering from lack of spontaneity, abulia, apathy, and disturbance of rapport were chosen as subjects in this research. The cases with hallucination, delusion and disturbance of the self were also included. Duration of illness is as follows: 111 for within one year 2 cases, 2–3 years 4 cases, 3–5 years 8 cases, 5–10 years 17 cases, more than 10 years 53 cases.The subjects are in most cases 20–50 years old.2) Initial daily dose was 100–600 mg, then gradually increased to maximum dose 1200 mg. Maintenance dose was 400–600 mg, and continued administration was at most for 3 months in the longest administered cases. Symptom‐changes including amelioration and exacerbation were most remarkable at 400–800 mg daily dose.3) Remarkable amelioration was seen in 8 cases (9.5%), moderate in 17 cases (20.2%), and slight in 20 cases (23.8%). Aggravation was seen in 5 cases (6.0%), no change were seen in 34 cases (40.5%). Remarkable and moderate amelioration were noted in 25 cases (29.8%).4) Most remarkable amelioration was seen at L‐Dopa 600 mg administration: Remarkable amelioration 6 cases, moderate 11 cases, and 17 cases (20.2%) in all. Next was seen at 400 mg administration: Remarkably ameliorated cases are 2, moderately 2; in total of 4 cases. However four cases exacerbated at 600 mg.5) The relation between duration of illness and therapeutic effect is as follows. In the cases ill for more than 10 years, which show personality deterioration, any amelioration is hopeless. Generally speaking it is effective for the cases ill for within 10 years.6) The evaluation result on 74 cases is as follows. Disturbance of rapport was the most improved: Remarkably ameliorated cases were 5, moderately 18, and amelioration rate was 31.5%. Disturbance of emotional expression was ameliorated second most: Remarkably ameliorated cases were 8, moderately 11; the rate 26.4%.7) As exacerbated cases, 10 cases of excitement were noted.In relation to the above‐mentioned results, we discussed L‐Dopa'

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1972.tb01119.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SummaryTo elucidate the absorption, intracellular location and pathogenicity of clioquinol, micro‐autoradiographic studies were done.131I‐clioquinol was administered under different methods to 6 mongrels, 2 inbred beagles and a cat. Shortly after i.v.‐ or i.p.‐injections of the substance to the mongrels and cat, a high concentration of radioactive grains was seen in the following nervous system: Nerve cells of the spinal root ganglia, spinal grey matter and nuclei in the brain stem; peripheral nerves; capsular cells of the spinal root ganglia; glial cells in the spinal cord, brain stem and periventricular region of the cerebrum. Though in lesser degree, orally administered radioactive clioquinol was also detected in the nervous system of the mongrels. I.p.‐injected beagles showed, however, a low concentration of the grains in the nervous system. This may indicate strain‐difference of dogs for the neurotoxicity of

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1972.tb01120.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

SummaryThe cerebral cortex, cerebellar cortex, hypothalamus, caudate nucleus, putamen, globus pallidus and hippocampus of the rabbit during the status epilepticus induced by the cardiazol injection were examined under the electron microscope, and were compared with the normal materials. Various fine structural alterations are observed in the neurons of the examined regions, especially in those of the hippocampal and hypothalamic regions. In the nerve cell cytoplasm of these regions, ribosomes are diffusely scattered all over the cytoplasmic matrix losing their original arrangement. The synaptic vesicles have a tendency to be distributed unevenly or to be lumped together in the synaptic boutons there. Glycogen granules in both the neurons and the glial cells of all the examined regions disappear completely. These findings might bs due to an energy exhaustion in the brain metabolism by the convulsive activity.

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1972.tb01121.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1972.tb01122.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1972.tb01123.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY