摘要:

Summary(1) Org GB94 (Mianserin hydrochloride), a new tetracyclic antidepressant, was administered to 21 patients with depression or with depressive states.(2) Remarkable antidepressive response was obtained with Org GB94 in moderate and mild forms of endogenous, involutional and senile depression.(3) The onset of action of Org GB94 was rapid.(4) Anticholinergic side effects were extremely rare and other untoward effects were mild in nature.

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00138.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00139.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SummaryStudies were made on the groups of psychiatric symptoms of Neuro‐Behçet's syndrome in six cases considered to be brain stem encephalitis, including one case of autopsy.Psychiatric symptoms appeared from one to eight years after neurological symptoms first occurred.This group of psychiatric symptoms can be divided roughly into the early‐stage, middle‐stage, terminal‐stage and episodic groups.The initial‐stage symptom group concerns mainly a change in, and regression of, personality, consisting of being childish, shallow, indifferent, careless, rude, slow in action, euphoric, or depressive.The middle‐stage symptom group is made up of indifference, forced smiling, forced crying, amnesia, recent memory impairment, and disorder of sleep rhythm.The terminal‐stage symptom group comprises the “locked‐in” syndrome, which if advanced, will become Apallisches Syndrome.The episodic symptom group is made up of pathologically abnormal experiences such as hallucinations and delusions and symptoms due to a decline in the level of consciousness such as confusion, delirium and twilight state.Dementia hitherto mentioned in Neuro‐Beh¸et's syndrome should be classified

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00140.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SummarySerum CBZ concentration was determined by gas liquid chromatographic method in 14 epileptic patients (32 samples) treated initially with CBZ alone, and the following results were obtained:1. The relationship between serum CBZ concentration and CBZ dose was expressed by a regression line that sloped sharply upwards at first: high serum concentration was obtained from small dose up to the end of three weeks after initiation of CBZ administration. After the 3rd‐4th treatment week, regression coefficient was reduced by half, and the regression line had a gentler slope.2. As the treatment was continued longer, serum CBZ concentration and serum concentration/dose ratio became lower. The relationship between duration of CBZ treatment and serum concentration/dose ratio was expressed by a regression curve representing a quadratic function with negative coefficient, the ratio being high in early stage of the treatment. This regression curve shows that the ratio reached its maximum value at the 10.5 days after initiation of the treatment. The ratio was stabilized at a low level about 3–4 weeks after that.3. From the results, serum CBZ concentration was confirmed to be more dependent on duration of the treatment than on dose. This was inferred, on the basis of documentary research, to be attributable to the auto‐induction of CBZ metabolism, the inference of which seemed to be supported by the results of measurement of time‐course change in serum concentration in five cases of the present series. The results in one of the said five cases suggest that serum CBZ concentration varies greatly within 12 hr.4. On the basis of these results, it is proposed that spontaneous decrease in serum CBZ concentration must be countered not merely by increase in CBZ dose, but by increase in the number of dosages/day for suppression of excessive diurnal change in serum concentration

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00141.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00142.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SummaryEffectiveness of 5‐hydroxy‐L‐trytophan as an antidepressant drug was studied with 59 patients with depressive symptoms using Rating Scale for Depression made by Clinico‐Psychopharmacology Research Group in Japan for a preparatory step of a double blind clinical study of 5‐hydroxy‐L‐tryptophan treatment of depression. A daily dose of 150–300 mg of 5‐hydroxy‐L‐tryptophan was administered for three weeks. Favorable responses were observed in 40 patients (67.8%), of whom 13 patients were markedly improved. These effects were noticed in 32 patients (80% of the improved patients) within a week of the treatment. Analysis of General Improvement Rating in the various subtypzs of depressive symptoms indicated that endogenous depression and involutional or senile depression were the preferable indication of 5‐hydroxy‐L‐tryptophan loading. The main side effects of 5‐hydroxy‐L‐trytophan were gastrointestinal disturbances which were minimized by the simultaneous administration of

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00143.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SummaryDiphenhydramine hydrochloride (DPHm) solution 1.5% was given intravenously to 375 healthy males (mean age; 23.8 years) at a rate of 30mg/min. The dosages injected were 2mg/kg (N = 157); 1.5mg/kg (N = 94); 1.0mg/kg (N=72); 0.5 mg/kg (N = 52). As a result, the 6c/sec spike and wave discharges (WSP) was found in 19.7%, 9.6%, 20.8%, and 15.4% of cases, respectively.Comparisons were made between the WSP incidence versus past histories and Cornell Medical Index results, and between WSP positive and WSP negative subjects. No significnat differences were observed in any of these parameters.

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00144.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SummaryEighty‐four healthy subjects (47 males and 37 females) ranging in age between 9 and 76 years were employed in a study of the relations of the CNV morphology with the CNV amplitude, the reaction time and the MPI score. The results were as follows:1. We classified a new type of Plateau (P) in the negative‐going limb (NGL) types.2. There was no sex difference in the NGL types, but the positive‐going limb (PGL) types were influenced by age, and the type II tended to increase between the ages of 40–59 years old.3. As a whole, the type B in the NGL and the type I in the PGL were most prominent regardless of age, session or paradigm. The type FD was very rare and appeared only in the session N. The types III and IV failed to be found in any healthy subjects.4. Using the matched control study, the relations of the morphology with the CNV amplitude, the reaction time and the MPI score were analyzed. The conventional CNV amplitude in the sessions C and R increased in the sequences of the types B‐A‐P and the types I‐II, and the CNV amplitudes in the session N increased in the sequences of the types A‐B‐P and II‐I. The reaction time in the sessions C and R tended to prolong in the sequences of the types P‐B‐A and II‐I. With the MPI, as the N‐score increased with a decrease of the E‐score, the NGL types changed from the type P to A through B in the conventional CNV and from the type A to B or P in the session N, while the PGL types changed from the type I to II in the conventional CNV and from the type II to I in the session N.5. We suggest that there is a twofold arousal process, specific (task‐relevant) and general, behind these types and that the dynamic balance of this process may influen

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00145.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SummaryUsing serially sectioned spinal cords, studies were made on the number of Alzheimer's neurofibrillary tangles, and the distribution of lipofuscin in five cases of clinically and histopathologically confirmed Alzheimer's disease, 10 cases of similarly confirmed senile dementia and 10 cases of mentally normal people.Alzheimer's neurofibrillary tangles were not observed at all in Alzheimer's disease and in the control group. A very small number of them were found in the inter‐mediolateral cell, posterior column cell, anterolateral cell, and anteromedian cell groups in three cases of senile dementia.The deposition of lipofuscin was high in the anterolateral and posterolateral cell groups and nucl. dorsalis in all of the cases of Alzheimer's diseases, senile dementia and the control group.It is worthy of note that the Alzheimer's group, for its age, showed a relatively greater amount of lipofusci

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00146.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

SummarySpongy state and degeneration of the white matter in the 6‐aminonicotinamide intoxicated rats were studied neuropathologically and electromicroscopically.Young albino rats, four weeks of age, received 0.1% of 6‐aminonicotinamide solution intraperitoneally as a single dose of 10 mg/Kg of body weight. Four hours after the administration, paralysis of the hind limbs occurred in the rats.Neuropathological investigations revealed a characteristic spongy and degenerative change of white matter as well as gray matter of the central nervous system. Corpus callosum, cerebellar cortex, and optic nerves showed edematous and spongy degeneration in the early stage of the experiment.Ultrastructural changes of myelin sheath were initially seen in the vicinity of severely damaged oligodendrocytes. The vacuoles in the myelin, i.e. intramyelinic vacuoles, were formed by splitting between the innermost myelin lamellae and axon. Axons remained usually unchanged in the early stage. The pathogenesis of ultrastructural changes of the white matter in the 6‐aminonicotinamide intoxication was disc

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1978.tb00147.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY