摘要:

SUMMARYAlthough omeprazole has a long duration of action and has usually been given in the morning, there are theoretical advantages in administering antisecretory drugs in the evening as has been shown for the H2‐receptor antagonists. The aim of this study was to compare the effects of placebo and 20 mg omeprazole given either in the morning or evening, on gastric acidity, plasma gastrin levels and plasma omeprazole in 6 duodenal ulcer patients. The 24‐hour mean pH (± S.E.M.) was: placebo 1.7 ± 0.1; morning doing, 3.9 ± 1.8 (P<0.01); evening dosing, 2.9 ± 1.1 (N.S.). There was a large inter‐individual variability of intragastric acidity in response to omeprazole, which was reflected both in the plasma gastrin and in the area under the plasma omeprazole concentration–time curve. Morning administration of omeprazole is optimal, but variability in the patient response to 20 mg omeprazole is

ISSN:0269-2813    

DOI:10.1111/j.1365-2036.1992.tb00550.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SUMMARYThirty consecutive patients with endoscopically proven duodenal ulceration who hadHelicobacter pyloriinfection on culture and histology, were treated with tripotassium dicitrato bismuthate (1 tablet q.d.s., 400 mg metronidazole t.d.s. and 500 mg tetracycline t.d.s. for one week, followed by the bismuth salt for a further 3 weeks. All patients were endoscoped at entry and 4 weeks after cessation of treatment, to check for ulcer healing andH. pylorieradication. Two antral biopsies were taken at each endoscopy for histological and microbiological evidence ofH. pyloriinfection. Complete healing of duodenal ulcers was observed in 27/30 patients (90%). Gastritis improved or completely resolved in 26 patients. Eradication ofH. pyloriwas achieved in 27 patients. Of the three patients who failed to heal, two wereH. pylori‐positive at follow‐up and one wasH. pylori‐neg

ISSN:0269-2813    

DOI:10.1111/j.1365-2036.1992.tb00551.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SUMMARYOne hundred and thirty north Nigerian patients with non‐ulcer dyspepsia were treated with tripotassium dicitrato bismuthate and amoxycillin, or antacid. Symptoms resolved in 28 (33%) of bismuth and amoxycillin recipients completing the trial compared with 1 (4%) of the antacid recipients. Symptomatic improvement did not relate to clearance ofHelicobacter pylor

ISSN:0269-2813    

DOI:10.1111/j.1365-2036.1992.tb00552.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY