|
21. |
Effects of X-RAY Irradiation on Natural Killer (NK) Cell System. II. Increased Sensitivity to Natural Killer Cytotoxic Factor (NKCF) |
|
Immunopharmacology and Immunotoxicology,
Volume 11,
Issue 2-3,
1989,
Page 521-534
UchidaA.,
MizutaniY.,
NagamutaM.,
IkenagaM.,
Preview
|
PDF (646KB)
|
|
摘要:
AbstractIrradiation with low-doses of X-rays of tumor cells elevated their susceptibility to lysis by natural killer (NK) cells in an accompanying paper. Cytotoxicity assays conducted at the single cell level revealed that X-ray irradiation of K562 cells did not affect the number of effector-target conjugates but increased the frequency of dead conjugated target cells. During interaction with K562 cells large granular lymphocytes released a soluble cytotoxic factor (NKCF) that killed the target cells. X-ray irradiation did not affect the NKCF stimulatory ability of K562 cells, while it elevated their sensitivity to the lytic effect of NKCF. In contrast to X-rays, exposure to ultraviolet (UV) radiation of K562 cells did not elevate their NK sensitivity but rather reduced it. Treatment with mitomycin C produced no effect on NK sensitivity. These results indicate that X-ray irradiation elevates the target sensitivity to NKCF, which may be involved in the increased NK sensitivity, and that the X-ray effect may be different from that of UV radiation or DNA synthesis inhibition.
ISSN:0892-3973
DOI:10.3109/08923978909005382
出版商:Taylor&Francis
年代:1989
数据来源: Taylor
|
22. |
Conference: Health of Inner Cities and Urban Areas |
|
Immunopharmacology and Immunotoxicology,
Volume 11,
Issue 2-3,
1989,
Page 537-537
ButterworthLori,
Preview
|
PDF (63KB)
|
|
ISSN:0892-3973
DOI:10.3109/08923978909005383
出版商:Taylor&Francis
年代:1989
数据来源: Taylor
|
|