摘要:

ABSTRACT:Ascitic fluids and sera from patients with malignant tumors were tested for their ability to modulate the mitogen‐induced blastogenic responses of normal subjects' peripheral blood mononuclear cells in vitro. The addition of either ascitic fluid or serum to cultures of normal blood cells greatly enhanced the blastogenic response of cells to phytohemagglutinin P, and markedly depressed the responses to concanavalin A and succinyl‐concanavalin A. The blastogenic response of the cells to pokeweed mitogen was unaffected by the addition of serum and depressed by the addition of ascitic fluid. Autologous normal serum also enhanced the response to phytohemagglutinin P but had no effect on the response to the other mitogens. These activities were concentration‐dependent and heat‐stable (56°C, 60 min) and could be detected even if the ascitic fluid or serum was added as late as the second day of culture. Cells that had been preincubated with serum or ascitic fluid and washed well before culturing with the mitogens responded in the same manner as cells cultured in the presence of serum or ascitic fluid. The mitogen‐induced blastogenic responses of mononuclear cells were not affected by the addition of autologous cells that had been preincubated with either serum or ascitic fluid, washed, and treated with mitomycin C. Indomethacin (2×10−7M) did not prevent the ascitic fluid‐mediated depression of blastogenic responses of normal cells. The ascitic fluid and serum of these cancer patients appeared to contain a specific immunoinhibiting substance which exerted its effects by a direct action on the responding mononuclear cells and not by the induction of s

ISSN:0271-7352    

DOI:10.1111/j.1600-0897.1982.tb00085.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT:Cases of endometrial carcinoma reviewed for this study were divided into two groups: 1) Premenopausal, perimenopausal and postmenopausal patients in whom a history of anovulation, obesity, ovarian hyperthecosis (including Stein‐Leventhal syndrome) or feminizing tumors, and/or exogenous estrogen intake were found; and 2) postmenopausal, elderly patients, without known hormonal or metabolic disturbances and without any history of estrogen therapy. In the first group, frequent associated findings were precursor stages of endometrial carcinoma, such as adenomatous and atypical hyperplasia. In the majority of cases, the cancer was confined to the endometrium, rarely infiltrating the myometrium. In the second group, the cancer was associated most often with an inactive, atrophic endometrium and frequently diffusely infiltrated through the myometrium, with lymphatic and vascular involvement. The lymphatic and plasma‐cell infiltrate was evaluated in both groups. It was found to be more abundant in the first group, both at the tumor‐host interface and perivascularly, than in the second.As reported in other malignancies of the female reproductive system, the presence or absence of a lymphocytic infiltrate as a morphological expression of local cellular immune response of the host correlates well with the biological behavior of the tumor. A challenging question is the relationship, if any, between hormonal factors and immune mechanisms in tumors arising in tissues such as the endometrium that, even normally, are targets of hormonal stimul

ISSN:0271-7352    

DOI:10.1111/j.1600-0897.1982.tb00086.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT:Using the test of antiglobulin serum consumption against the human ovarian antigen, investigations were conducted on the presence of antiovarian antibodies in the blood serum of 432 women with different diseases of the ovary and 50 healthy women as control group. Autoantibodies were found in 12 of 172 patients with inflammatory lesions of the ovary (7.0%), in 18 of 118 patients with ovarian failure (15.3%), and in 21 of 65 patients with malignancies of the ovary (32.3%).No autoantibodies were detected in any of the healthy women from the control group, in any of the 10 patients with tuberculosis of the adnexa, or in any of the 67 women operated upon for benign neoplasms of the ovary.The authors formulate the supposition that there may be a correlation between the occurrence of autoantibodies, lesions of the ovarian tissue, and the malignancy of the neoplastic process.

ISSN:0271-7352    

DOI:10.1111/j.1600-0897.1982.tb00087.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0271-7352    

DOI:10.1111/j.1600-0897.1982.tb00088.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0271-7352    

DOI:10.1111/j.1600-0897.1982.tb00074.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY