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1. |
Patient-Controlled Analgesia for Cancer Pain: A Long-Term Study of Inpatient and Outpatient Use |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 335-341
CitronMarc L,
KalraJagmohan,
SeltzerVicki L,
ChenSidney,
HoffmanMark,
WalczakMary B.,
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摘要:
The safety and efficacy of patient-controlled analgesia for the long-term control of cancer pain was tested prospectively. Respiratory rates, mental status, and pain relief were recorded at baseline and compared with those during the study period. Patients had a lower analgesic demand (i.e., self-administered less morphine during the nighttime); specifically, dosing declined48% from the daytime level. Respiratory rates did not change appreciably during the study and no cases of significant respiratory depression were encountered. Patients self-administered sufficient morphine to produce adequate but not complete pain relief in almost all trials. Pain relief was safely achieved by both intravenous and subcutaneous routes of administration in both the inpatient and outpatient settings. Mean 24-h morphine use stayed relatively constant even for patients receiving more than 2 weeks of treatment. In conclusion, patient-controlled analgesia is effective and safe therapy for the long-term control of severe cancer pain.
ISSN:0735-7907
DOI:10.3109/07357909209024792
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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2. |
Nonspecific Immunostimulation with Low Doses of Cyclophosphamide (LDCY), Thymostimulin, and Echinacea Purpurea Extracts (Echinacin) in Patients with Far Advanced Colorectal Cancers: Preliminary Results |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 343-348
LerschChristian,
ZeunerMartin,
BauerAndrea,
SiemensMichaela,
HartRainer,
DrescherMichael,
FinkUlrich,
DancygierHenryk,
ClassenMeinhard,
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摘要:
Outpatients (n = 15) with metastasizing far advanced colorectal cancers received immunotherapy consisting of low-dose cyclophosphamide (LDCY) 300 mg/m2every 28 days i.v., thymostimulin 30 mg/m2, days 3-10 after low-dose cyclophosphamide i.m. once daily, then twice a week, and echinacin 60 mg/m2together with thymostimulin i.m. All patients had had previous surgery and/or chemotherapy and had progressive disease upon entering the study. Two months after onset of therapy a partial tumor regression was documented in one and a stable disease in 6 other patients by abdominal ultrasonography, decrease of the tumor markers carcinoem-bryonic antigen (CEA), CA 19-9, CA 15-3, and/or chest roentgenography, which may also be attributed to the natural course of disease. Mean survival time was 4 months, 2 patients survived for more than 8 months. Immunotherapy was well tolerated by all patients without side effects.
ISSN:0735-7907
DOI:10.3109/07357909209024793
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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3. |
Simultaneous Radiotherapy and Chemotherapy with Carboplatin in Inoperable Squamous Cell Carcinoma of the Head and Neck: A Phase II Study |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 349-355
ZamboglouNikoiaos,
AchterrathWolf,
SchnabelThomas,
LenazLuigi,
KolotasChristos,
SchmittGerd,
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摘要:
Fifty-six untreated patients with inoperable squamous cell carcinoma of the head and neck were treated with carboplatin 70 mglm2i.v. daily on days 1-5 and 29-33 in combination with simultaneous conventional radiation up to a target volume dose of 50 Gy. Depending on tumor response and upon recommendation of surgeons, 21 of 56 patients underwent surgery after a radiation dose of 50 Gy and two courses of carboplatin. Patients who showed pCR after surgery received no further radiotherapy. In all other patients radiotherapy was continued using a shrinking field technique up to a target absorbed dose of 70-74 Gy. Combined modality induced 66% complete remission (CR) and an overall response rate of 98%. After completion of the whole treatment program (combined modality±surgery) 53 (94%) of the 56 patients were disease free. The median survival for all patients is 25+ months and the percentage of two-year survivors is 53%. Myelosuppression was the most frequent toxicity, but rarely was severe; leukopenia and thrombocytopenia of WHO grade 3 occurred in 21% of the patients. No other toxicities above WHO grade 2 occurred. Nephrotoxicity, neurotoxicity and ototoxicity were not seen. The addition of carboplatin did not increase the rate of surgical complication over that expected for preoperative radiotherapy. Two patients died of pulmonary embolism after surgery. Combined modality with carboplatin and simultaneous radiation is a highly active and well-tolerated regimen for untreated patients with inoperable squamous cell carcinoma of the head and neck.
ISSN:0735-7907
DOI:10.3109/07357909209024794
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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4. |
Immunotherapy with Sensitized Lymphocytes |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 357-369
ChangAlfred E.,
ShuSuyu,
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ISSN:0735-7907
DOI:10.3109/07357909209024795
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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5. |
Feline Leukemia Virus: Pathogenesis of Neoplastic Disease |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 371-389
RezankaLouis J.,
RojkoJennifer L.,
NeilJames C.,
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ISSN:0735-7907
DOI:10.3109/07357909209024796
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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6. |
The Role of Surgery in Early Stage Glottic Carcinoma |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 391-398
MyssiorekDavid,
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PDF (728KB)
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ISSN:0735-7907
DOI:10.3109/07357909209024797
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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7. |
Molecular Biology in the Diagnosis and Prognosis of Solid and Lymphoid Tumors |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 399-416
LebovitzRussell M.,
AlbrechtSteffen,
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ISSN:0735-7907
DOI:10.3109/07357909209024798
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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8. |
The Polymerase Chain Reaction: Its use in the Molecular Characterization and Diagnosis of Cancers |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 417-429
KawasakiErnest S.,
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ISSN:0735-7907
DOI:10.3109/07357909209024799
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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9. |
Introductory Comments |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 431-431
HirshautYashar,
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ISSN:0735-7907
DOI:10.3109/07357909209024800
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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10. |
Atypical Hyperplasia: A Morphologic Risk Factor for Subsequent Development of Invasive Breast Carcinoma |
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Cancer Investigation,
Volume 10,
Issue 5,
1992,
Page 433-441
TavassoliFattaneh A.,
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PDF (913KB)
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ISSN:0735-7907
DOI:10.3109/07357909209024801
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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