ISSN:0735-7907    

DOI:10.3109/07357909309024836

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309024837

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309024838

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309024839

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

Hematopoietic growth factors may be useful in improving the clinical effectiveness of arabinofuranosylcytosine (ara-C). In vitro studies have indicated that interleirkin 3 (IL-3) and, to a lesser extent, granulocyte-macrophage colony-stimulating factor (GM-CSF), but not G-CSF or M-CSF, may be capable of specifically augmenting the abiliry of ara-C to kill leukemic myeloid cells by pharamacological and cyto-kinetic mechanisms including increase of intracellular ara-CTP/dCTP pool ratios and enhanced ara-C DNA incorporation in leukemic blast cells, decrease of IC 90 of ara-C for leukemic colony-forming cells (CFC) as compared with normal CFC growth, and recruitment of quiescent leukemic cells into the cell cycle. In contrast, the combination of ara-C with M-CSF or with the leukemia inhibitory factor (LIF) appears to be useful in overcoming the block in differentiation of leukemic blast, while the effects of GM-CSF and IL-3 on ara-C-induced differentiation appear limited. The combined treatment of human myeloid leukemia cells by ara-C and LIF is associated with down-regulation of c-mycgene expression, transcriptional activation ofjuntfosgene expression, and features of functional differentiation (e.g., the capability to reduce nitroblue tetrazolium, to express lysozyme, or to display differentiation-related surface receptors including C3bi and thec-fmsprotein). On the basis of these in vitro studies first clinical trials are underway that are examining the efficacy of ara-C combinations with these molecules for the treatment of myeloid disorders.

ISSN:0735-7907    

DOI:10.3109/07357909309024840

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309024841

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309024842

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

In order to determine the effect of recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF), it has been administered to patients undergoing autologous or allogeneic bone marrow transplant (BMT). Results in patients undergoing antologous or allogeneic BMT indicate that rhGM-CSF is minimally toxic and is associated with reduced morbidity. Trials also indicate that rhGM-CSF may be an acceptable therapy for patients with marrow graft failure since survival appears to improve substantially in patients who received rhGM-CSF compared with historical control patients.

ISSN:0735-7907    

DOI:10.3109/07357909309024843

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309024844

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309024845

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor