摘要:

Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (A1PD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an increased incidence of constitutional signs and symptoms. Radiographic findings in both groups were indistinguishable from those of malignant lymphomas. Of all the clinical characteristics examined to establish a prognostic significance, a positive history of allergies and the presence of polyclonal gammopathy were associated with a worse prognosis. Of the 22 patients treated, 15 initially received single agents and seven combination chemotherapy. The median survival of patients who received combination chemotherapy has not been reached at 38 months, while that of the patients on single agents is 10 months. Of 9 patients who achieved complete remission, 7 remain alive, while all 14 patients who failed to achieve a complete remission have already expired. Patients initially treated with combination chemotherapy tolerated treatment well and had a more favorable outcome with only three deaths (mostly secondary to tumor recurrence) in seven patients. Even though these entities are not considered malignant morphologically, their clinical behavior frequently resembles that of a lymphomatous disorder as confirmed by the short median survival of 22 months for AIPD and 24 months for ILA. Once progressive disease is documented, we recommend combination chemotherapy as initial therapy.

ISSN:0735-7907    

DOI:10.3109/07357908309063292

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

摘要:

Antiserum to ICP 10, a herpes simplex virus type 2 (HSV-2) protein that is expressed in cells neoplastically transformed by viral DNA sequences within the Bgl II/Hpa I CD fragment, specifically precipitates the ICP 10 protein from HSV-2 infected cells and stains cells infected with HSV-2 for 4 to 16 hrs by indirect immunofluorescence. At 4 hr post infection (p.i.), the staining is primarily perinuclear, while at 16 hr p.i., it is cytoplasmic and intranuclear. Compartmentalization studies indicate that the35S-[L]-methionine labeled ICP 10 is detectable in both the cytoplasmic and nuclear fractions early and late in infection. However, in its phosphorylated form, ICP 10 is undectable in the nuclear fraction late in the viral reproductive cycle. Anti-ICP 10 serum stains a high (75%-83%) proportion of cervical tissue with pathological findings of dysplasia or carcinoma, as well as atypical exfoliated cells from these patients. Cervical tumor tissue from 4 of 12 patients also stains with antiserum to another purified viral protein complex designated ICP 12/14. In the majority of atypical cells with mild or moderate changes, ICP 10 localizes in the cytoplasm, while the majority of atypical cells with severe changes also display nuclear staining with anti-ICP 10 serum. While exfoliated atypical cells from 60% of patients with dysplasia are positive for ICP 10, those from only one half of these patients stain also with anti-ICP 12/14 serum and this staining is strictly cytoplasmic. Atypical cells from three patients in these series stain with the anti-HSV-2 serum but are negative for both ICP 10 and ICP 12/14. Exfoliated atypical cells from patients with CIS or invasive cancer stain equally well with all three antisera.

ISSN:0735-7907    

DOI:10.3109/07357908309063293

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

摘要:

Gastrointestinal complications in acute leukemia have been infrequently reported. Reported here is a review of all patients on the hematology teaching service with acute leukemia from 1974 to 1980 and those with intestinal complications. Of the 50 patients with acute leukemia, 14 (28%) developed an acute abdominal catastrophe. They presented with an acute surgical abdomen, diarrhea, gastrointestinal bleeding, and a paralytic ileus. All were granulocytopenic and thrombocytopenic. All but one episode was associated with the death of the patients; survival ranged from 4 to 26 days (median 9 days) after their last dose of chemotherapeutic drugs. Cytarabine was administered in 13 of the 14 patients. It is believed that bowel necrosis which causes death in acute leukemia occurs more frequently than previously thought. There is a close association of the clinical syndrome with chemotherapeutic drugs, especially cytarabine.

ISSN:0735-7907    

DOI:10.3109/07357908309063294

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

摘要:

This is the second of a two part series. In this issue, Part II presents the therapeutic results of hepatic artery ligation and infusion chemotherapy (either IA hepatic or IV portal), radiotherapy (either external or internal), and the newer techniques of transcatheter embolization, hyperthermia, etc., are reviewed. The outcome of many recent studies using various combinations of the above regional modalities are presented. The most effective permutation and combination of drugs remains to be determined by future clinical trials.

ISSN:0735-7907    

DOI:10.3109/07357908309063295

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

摘要:

This is Part two of this paper describing the biology of the naturally occurring RNA tumor viruses (oncornaviruses) in“higher”vertebrates. Part one [Cancer Investigation 1(2):163-174, 1983] discussed cat retroviruses. Part two deals with bovine and primate, including human, RNA tumor viruses. A. review of retroviruses in“lower”animals preceded this paper

ISSN:0735-7907    

DOI:10.3109/07357908309063296

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908309063297

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908309063298

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908309063299

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908309063300

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908309063301

出版商:Taylor&Francis    

年代:1983

数据来源: Taylor