摘要:

AbstractThirty adult patients with relapsed or refractory malignant lymphoma underwent a Phase I-II trial of salvage chemotherapy combining methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI protocol). All patients had been extensively pretreated. At the time of salvage therapy, 21 patients had visceral involvement and 23 patients were refractory. The overall response rate was 50% (11 patients in complete remission and 3 patients in partial remission). The main toxicity was myelosuppression; 4 treatment-related deaths occurred and 17 patients died of tumor progression with a median of 5 months. The MAMI protocol showed similar antitumoral efficacy to that of other salvage chemotherapy regimens used for poor prognosis malignant lymphoma but was more toxic. However, a response rate of 45 % in refractory patients should be taken into account and this drug association deserves further investigation with regard to the selection of patients for bone marrow transplants.

ISSN:0735-7907    

DOI:10.3109/07357909009017540

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractPhase I and II trials of vincristine infusion have demonstrated the safety and efficacy of this approach in the treatment of patients with refractory non-Hodgkin 's lymphoma. Subsequently, a trial was designed to evaluate this technique in untreated patients. Repeated 5-day infusions of vincristine 0.25 mg/m2per day were incorporated into a CHOP-CCNU regimen and administered to 24 patients with advanced diffuse large-cell lymphoma. Objective responses occurred rapidly and were observed in 18 (75%) patients in whom 13 (54%) were complete. Toxicity was generally mild to moderate and neurotoxicity appeared to be no worse than typically observed with bolus vincristine. Complete responses have been durable in most patients and 10 (77%) of the complete responders have not relapsed. At this time, 9 (38%) of the total patients remain alive and without evidence of disease from 3.8 to 7.3 years from the start of treatment. One patient died of disseminated gastric cancer at 3.3 years from the start of therapy and there was no evidence of lymphoma at exploratory laparotomy. Infusion of vincristine may be safely incorporated into multiagent chemotherapy programs of the CHOP type for non-Hodgkin's lymphoma. Its potential for protracted nonmyelosuppressive cell kill would appear attractive in designing future trials for this disease.

ISSN:0735-7907    

DOI:10.3109/07357909009017541

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractWe employed a new method to administer etoposide in high doses to 51 patients undergoing autologous bone marrow transplantation. Undiluted etoposide (20 mg/ml) was sterilely drawn into Luer-Lok plastic syringes, connected to IV extension tubing, and infused intravenously by a syringe pump over 3-4 hours. Patients received etoposide at doses ranging from 400 to 1600 mg/m2per day (median dose: 800 mg). Total actual etoposide doses infused during the transplant period ranged from 2200 to 9000 mg. The infusion rate range was 4.1–13.4 mg/min. No episodes of hypotension, bronchospasm, or hemorrhagic cystitis were noted during or within 3 days of the etoposide infusion. In addition, no cracking of the infusion apparatus was observed in any of the 148 separate infusions. Serum bicarbonate concentrations fell significantly in 6 patients who received the higher etoposide doses. This procedure is superior to the standard method of etoposide drug delivery, since large doses of etoposide may be given without the concomitant administration of large volumes of fluid over short periods of time.

ISSN:0735-7907    

DOI:10.3109/07357909009017542

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractThe effect of coculturing nonadherent and plastic adherent cells from the spleen with MOPC 104E KI81 for short (24 h) and long terms (7 days) was investigated. In both culture systems, the effect of the spleen cells on the secretion of IgM by plaqueforming cells assay and growth of the plasmacytoma by cell counts and flow cytometry was measured. In these studies, a low effector target (E:T) ratio which did not produce cytotoxicity to MOPC 104E cells was used. We observed that while nonadherent spleen cells from normal or MOPC 104E-primed mice inhibited secretion of IgM by the MOPC 104E cells, they stimulated the proliferation of MOPC 104E cells two times faster than MOPC 104E cells cultured alone. Plastic adherent cells from the spleens of normal mice or MOPC 104E-primed mice also inhibited secretion of IgM by the tumor cells as measured by plaque formation, and stimulated proliferation of MOPC 104E in 24 h coculture. Plastic adherent cells from normal nonprimed mice initially stimulated the myeloma to grow, but by 24 h, a large fraction of the population was in the G1or possibly resting state. The effect of nonadherent and plastic adherent cells on the stem cell activity of MOPC 104E was also tested in 7-day colony-forming assays. Nonadherent cells had no effect on colony-forming units or plaque formation. Plastic adherent cells from normal spleen cells inhibited plaque formation by 68% but had no effect on colony formation. However, plastic adherent cells from spleens of mice primed in vivo with MOPC 104E tumor cells suppressed plaque formation by 98% and also reduced colony formation. The results showed that inhibition by macrophages of IgM production by MOPC 104E cells is independent of cell proliferation. The adherent macrophages from both normal and in vivo-primed spleen cells were Mac. 1 positive after 7 days of coculture with MOPC 104E cells. However, the density of Mac. 1 was greater on primed macrophages.

ISSN:0735-7907    

DOI:10.3109/07357909009017543

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909009017544

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909009017545

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909009017546

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909009017547

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909009017548

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909009017549

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor