摘要:

Eighty-three patients with rapidly progressing breast cancer (RPBC) were entered into a study of primary chemotherapy (cyclophosphamide, methotrexate, and 5-fluorouracil) and subsequent randomization to surgery or radiotherapy for control of local/regional disease. Eighty-three of these patients with redness, warmth, and edema compatible with clinical“inflammatory breast cancer”served as the focus for our analysis of factors associated with improved survival. The stage-specific disease-free intervals (DPI) of 36 and 21 months were substantially longer than in the earlier series (26 and 16 months) from the same institution. The evaluation of individual prognostic indicators revealed that the initial tumor size and the initial response to chemotherapy were the two independent factors most important in predicting the DPI. The continuing unmaintained 1-year remission in at least 12 patients supports the rationale for aggressive therapy in RPBC or“inflammatory breast cancer.”

ISSN:0735-7907    

DOI:10.3109/07357909309018867

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

Twenty-two patients with malignant lymphoma were treated with three different COP-BLAM infusional chemotherapy protocols at the Jersey Shore Medical Center. The treatment group included 18 patients with large-cell lymphoma, 3 patients with Hodgkin's disease, and I patient with composite lymphoma (large-cell lymphoma and Hodgkin's disease). Three patients were treated with COP-BLAM III, 9 with COP-BLAM IV, and 10 with COP-BLAM V. The age of the patients at diagnosis ranged from 18 to 74 years, with a median age of 64 years. One patient had stage 1 bulky disease, 4 had stage II bulky disease, 3 had stage III disease, and 14 had stage IV disease. Twenty patients were evaluable for response; 2 were too early to evaluate. Complete response (CR) was seen in 18 of the 20 evaluable patients (90%). Potential cure (excludes non-lymphoma-related deaths) at 24 months is projected at 78%. Eleven patients are presently without disease and off therapy (55%). Projected failure-free survival at 2 years is 71% (a failure being death from any cause). Eleven of 22 patients developed 15 febrile episodes. Vin-cristine neuropathy was seen in 6 patients. Subclinical pulmonary fibrosis was seen in 1 patient. There was one cardiotoxic death. The COP-BLAM infusional protocols are highly effective, tolerable regiments that are applicable in community hospitals and can yield good response rates, with a high percentage of disease-free survivors in all age groups. The treatment can be completed in a short period with acceptable toxicity.

ISSN:0735-7907    

DOI:10.3109/07357909309018868

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

Chemocoagulation therapy was evaluated in an experimental model of metastasis of marine lymph nodes following injection of a suspension of mitomycin C-containing activated carbon particles in 80% ethanol (MMC-CH-ET) into the popliteal lymph node. Lymph node metastasis was induced in the left popliteal and the lumbar lymph nodes 8 days after injection of mouse leukemia P388 cells into the footpad of the left hindleg of BDFI mice. When MMC-CH-ET was injected into the left popliteal lymph node, it immediately left this site and entered the lumbar lymph node via lymphatic vessels. When compared with tissue concentrations of mitomycin C following injection of an aqueous solution of this drug, the mitomycin C concentration of MMC-CH-ET was maintained at significantly higher levels for 2 hr following injection both at the site of injection and at secondary lymph nodes. Furthermore, coagulative necrosis was identified histologically throughout the injected lymph node and the secondary lymph node, including the metastatic site. The mortality of mice treated with MMC-CH-ET injection was significantly reduced and lymph node metastasis was controlled with MMC-CH-ET when compared with the results for mice treated with an aqueous solution of mitomycin C or treated by surgical lymph node dissection. In this report, we suggest that the use of MMC-CH-ET as a therapeutic agent may be useful in targeting lymph node metastasis.

ISSN:0735-7907    

DOI:10.3109/07357909309018869

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

We examined the effects of timing of administration of etoposide on cytosine arab-inoside (ara-C) incorporation into DNA in L1210 ascites tumor. At 1 hr after injection of ara-C, 3-hr and 6-hr pretreatments with 15 mg/kg of etoposide increased ara-C incorporation to more than 200% as compared to that of ara-C given alone. Simultaneous administration of etoposide, however, decreased ara-C incorporation to 33% of that of ara-C alone. These results might explain the previously reported sequence dependency of the antitumor effect of etoposide and ara-C.

ISSN:0735-7907    

DOI:10.3109/07357909309018870

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

We have examined the status of the Wilms' tumor suppressor gene (W77), residing at chromosome II band p13, in a total of 40 cancers of the female reproductive tract. Northern blot analysis revealed that the WTI gene is expressed in a large percentage of ovarian tumors (75%) analyzed. Single-strand conformation polymorphism analysis was performed on all the tumors in this study in an attempt to detect mutations within the WTI gene. Only silent mutations were detected within intron 7 of WTI using this method. Loss of heterozygosity studies were performed at the WTI locus in several ovarian tumors and revealed that in the informative cases, heterozygosity was retained.

ISSN:0735-7907    

DOI:10.3109/07357909309018871

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

We measured the effect of MC-26 mouse colon cancers (of different sizes) on the circadian rhythm of hepatic ornithine decarboxylase (ODC) activity and hepatic ODC activity during the 24 hr after 60% hepatectomy. Tumor-free control mice showed a normal circadian rhythm of ODC activity with the highest levels at 1100 hr and the lowest levels at 2300 hr. The amplitude of the rhythm was diminished significantly in mice with a large tumor burden (3% of their body weight), and hepatic ODC activity was significantly less than in the tumor-free mice at every point during the 24 hr of the study. In mice with“early”tumors (0.3% of body weight), basal activity of ODC was normal and there was no reactive increase in activity following hepatectomy. In contrast, mice with“late”(3% of body weight) tumors had significantly lower basal ODC activities and the increase in ODC activity following hepatectomy was prolonged and exaggerated. We concluded that tumor burden is associated with abnormal ODC activity and that these differences are exaggerated after hepatectomy. Furthermore, although average ODC concentrations in tumor-bearing mice fell precipitously, the circadian rhythm in hepatic ODC persisted. This finding indicates early recognition by the host of tumor presence, which has a profound negative regulatory effect on hepatic ODC. Apparently, this effect does not impinge on circadian control mechanisms, indicating that these signals act independently.

ISSN:0735-7907    

DOI:10.3109/07357909309018872

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309018873

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309018874

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309018875

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309018876

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor