摘要:

AbstractThe value of adjuvant chemotherapy in primary osteogenic sarcoma (OSA) is still considered controversial by some. One reason may be that various reported series include patients with widely varying prognostic variables. To address this, the effect of chemotherapy on the continuous disease-free (CNED) survival was analyzed in 100 patients aged 21 yr or less with OSA of the femur. This classically poor prognostic group of patients represented 51% of all primary OSA seen at the Memorial Sloan-Kettering Cancer Center during the study interval. This study includes all patients aged 21 yr or less with fully malignant (Grade III---IVI IV) OSA of the femur and no metastases treated from November 1973 through November 1981. The first (T-4) protocol (31 patients) consisted of high dose methotrexate (HDMTX) with leucovorin rescue, cyclophosphamide (Cyc), and adriamycin. In the second (T-7) protocol (23 patients) the dose of HDMTX was increased to 12 glm2for prepubescent patients, and bleomycin, Cyc, and dactinomycin replaced Cyc. The current (T-10) protocol (46 patients) uses the same CT as T-7, but patients not having a complete response of the primary tumor to preoperative CT. receive additional cisplatinum (120 mg/m2) with adriamycin (30 mg/m2/day for two consecutive days). In 31 patients treated with T-4 the CNED survival was 32% with a minimum follow up of over 7 yr. On T-7, 15/23 patients with femur primaries had a CNED survival of 65% with all of the surviving patients followed for more than 5 yr. The addition of cisplatinum in T-10 has resulted in CNED survival rate of 77% in 34/44 patients (excluding two patients that died CNED during and after treatment); the median follow-up patients who are alive CNED is 33 months, with a minimum of 2 yr follow up on the last patient entered

ISSN:0735-7907    

DOI:10.3109/07357908409104370

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

摘要:

AbstractSeven patients with active Hodgkin's lymphoma who had relapsed 4--39 months following six or more cycles of MOPP were treated with a combination of vinblastine-bleomycin-cis-platin (VBP). Six patients attained a partial response of 1--8 months duration. There were no complete responses. The projected maximum long-term disease-free survivorship with this salvage program is less than 16%. All observed patients had Grade II---III nausea and vomiting, and neutrophil nadir counts less than 700/mm3. Three patients had platelet counts≤85,000/mm3. This program does not have significant potential as a salvage therapy for patients with Hodgkin's lymphoma relapsing after MOPP chemotherapy

ISSN:0735-7907    

DOI:10.3109/07357908409104371

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

摘要:

AbstractA case of extensive unilateral renal aspergillosis in a man with hairy cell leukemia is described. This case report is unique because of the long duration of the infection that is more characteristic of patients without malignancy. The degree of unilateral renal involvement found, which included invasion of kidney parenchyma, is uncommon in patients with malignancy. Such patients typically have diffuse disseminated disease with microabscesses. The literature on urinary tract aspergillosis in patients with and without underlying malignancy is reviewed

ISSN:0735-7907    

DOI:10.3109/07357908409104372

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908409104373

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908409104374

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908409104375

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908409104376

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908409104377

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908409104378

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908409104379

出版商:Taylor&Francis    

年代:1984

数据来源: Taylor