摘要:

AbstractDetailed records were maintained prospectively of all medications taken by 719 patients with advanced carcinoma of the lung or colon. Of this total, a cohort of 19 patients was identified who had ingested incidentally either nifedipine, diltiazem, verapamil, or trifluoperazine in standard therapeutic doses for a minimum of one month and a mean of 5.8 months and median of three months. Treatment with these calcium antagonists was well tolerated and, upon comparison with otherwise comparable patients who did not ingest a calcium antagonist, appeared to be associated with certain favorable outcomes, including delayed tumor progression and prolonged survival. These preliminary findings suggest that beneficial effects of such drugs observed with chronic treatment in experimental animal tumor models may occur in human disease and that definitive prospective, randomized, clinical trials of calcium antagonists administered continuously in ordinary therapeutic doses are both feasible and justified.

ISSN:0735-7907    

DOI:10.3109/07357909009012067

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractOcular toxicity is a common, but poorly understood, sequela from CMF chemotherapy. We investigated this toxicity in patients receiving CMF therapy. Detailed interviews in 210 patients revealed that new, unpleasant ocular symptoms developed in 42% of patients receiving CMF, in 39% of subjects receiving other regimens containing 5-fluorouracil (5-FU), and only in 18% of subjects receiving a variety of chemotherapy regimens not containing 5-FU. CMF-associated ocular symptoms usually consisted of mild to marked tearing, ocular pruritis, and/or burning. These toxicities usually began 11–17 days after starting a cycle of CMF and lasted for 10–15 days. 5-FU was detected in the tears of 12 tested patients within several minutes after intravenous 5-FU (peak concentrations as high as 60µg/ml). 5-FU tear concentrations did not correlate with the presence or absence of ocular toxicity. There is no established antidote for this toxicity although some patients have reported subjective benefit from cryotherapy, applied around the period of 5-FU injections, or cromolyn sodium eye drops.

ISSN:0735-7907    

DOI:10.3109/07357909009012068

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractTwenty four patients with epithelial ovarian cancer, who were treated by chemotherapy after debulking surgery, were monitored by serial monthly CA125 estimation and half-yearly computerized axial tomogram (CAT) of abdomen and pelvis. The efficiency of these monitoring methods and that of clinical examinaton were compared. The use of CA125 alone was superior to the use of clinical assessment alone in the detection of tumor progression (p0.05). Hence, CAT examination should not be used routinely to detect recurrence of tumor in patients without a raised CA125 level. However, in patients with Increased CA125 level, CAT examination had a place in locating and in determining the extent of the tumor which in selected patients may enable us to make changes in therapy without laparotomy and in other patients may help us to make a better assessment on whether further debulking is possible.

ISSN:0735-7907    

DOI:10.3109/07357909009012069

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractIn order to improve the therapeutic index of fluorouracil (5-FU), it has been combined with cisplatin (DDP) as synergistic agent and with allopurinol (HPP) as toxicity modulator. Patients with measurable colorectal carcinoma, previously untreated by chemotherapy, were randomized to receive either 5-FU alone 500 mg/m2push iv days 1–5 or HPP 3 300 mg po, days 1–5, 5-FU 800 mg/m2push iv, days 3–5 and DDP 50 mg/m2d6. Treatment was repeated every 4 weeks. Of 104 patients randomized, 82 were evaluable for response and survival. Six partial responses were seen in each treatment group (15%) and the median survival time was 7 months. Hematologic toxicities were comparable in both treatment groups, with a mean nadir white blood cell count of 3500/ vs. 3800/mm3and a mean nadir platelet count of 148,000/ vs. 203,000/mm3for HPP-5-FU-DDP and 5-FU, respectively. This study suggests that the addition of both HPP and DDP does not improve the activity of 5-FU.

ISSN:0735-7907    

DOI:10.3109/07357909009012070

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractCyclophosphamide has been considered one of the reference drugs of chemotherapy in randomized trials in hormone-refractory prostate cancer by the National Prostatic Cancer Project (NPCP). Ifosfamide, another oxazaphosphorine agent, and an analog of cyclophosphamide, appears to be more active and less toxic in a broad spectrum of tumors. Fifteen patients with metastatic hormone-refractory prostate cancer were treated with continuous infusion of ifosfamide 2 g/m2per day for 2 days, together with the uroepithelial protective agent Mesna 2.4 g/m2per day for 2 days, both to be repeated every 3 weeks. All patients have failed on previous hormonal therapy and 7 patients had received previous chemotherapy. The median age was 66 years. Fourteen patients were evaluable; none of whom achieved an objective response. Four patients were stabilized and 10 had disease progression while on chemotherapy. Major toxicity included 2 reversible encephalopathy, 3 grade I reversible renal toxicity, and 1 hemorrhagic cystitis. We concluded that ifosfamide given in this schedule in this group of patients is not an active agent in prostate cancer.

ISSN:0735-7907    

DOI:10.3109/07357909009012071

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractIn the course of development of an in vivo invasion model, sublines of a series of allogeneic and isogeneic carcinoma cell lines have been selected that show enhanced invasion of the peritoneum. It was found that, during the proliferation of tumor cell lines in ascitic form in the abdominal cavity, small numbers of cells infiltrated or firmly adhered to the peritoneum in at least 8/12 of the tumor-host combinations tried. After thorough washing of the peritoneum it was disaggregated by an enzyme mixture, and the resulting mixture of normal and tumor cells was inoculated intraperitoneally. Peritoneal isolations were made serially for 3 to 12 times. In 6 of 8 cases where the isolation produced a stable ascites, the cells showed enhanced peritoneal invasion compared with the parent cell line. The invasion of some of the cell lines was tested in another invasion model consisting of cultured mouse buccal mucosa (9/10 cell lines invaded the explant). In 3/3 cell lines showing enhanced peritoneum invasion in vivo, there was no enhanced invasion of the buccal mucosa. The enhanced peritoneum invasion appears to be tissue specific rather than a general increase in invasion potential. Pairs of high-and low-invasive cell lines were obtained that should be useful for screening for invasion modulating agents using the mouse ascites/peritoneum in vivo model. It is suggested that the method might be generalized to produce various tumor cell lines that target for the normal tissues that are adjacent to proliferating solid or circulating tumors.

ISSN:0735-7907    

DOI:10.3109/07357909009012072

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractIn order to determine if recombinant interferon-γ(rIFN-γ) can augment the effect of recombinant interleukin-2 (rIL-2) in generating lymphokine-activated killer (LAK) cells, we have incubated normal peripheral blood mononuclear cells (PBMC) with these lymphokines for 3 days and then tested their LAK and natural killer (NK) cell activity. We have found that LAK activity in PBMC from 13 out of 13 normal donors was increased by the combined lymphokines above that due to either lymphokine alone, provided that rIL-2 was present at suboptimal concentration: Optimal levels of rIFN-γ(100 U/ml) were able to enhance the LAK-inducing activity of suboptimal levels (5 U/ml) but not optimal levels (100 U/ml) of rIL-2. NK activity showed a similar response to these concentrations of lymphokines. Activation of LAK/NK cells was accompanied by increases in the percentages of Leu 19+(CD56) cells and TAC+(IL-2-receptor) cells, and in the intensity of TAC antigen expression. These results indicate that combination rIFN-γand rIL-2 may be more effective in generating LAK/NK cells than rIL-2 alone, particularly with suboptimal concentrations of rIL-2 such as occur during continuous infusion therapy with this agent.

ISSN:0735-7907    

DOI:10.3109/07357909009012073

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractTwenty-one patients with advanced gastric adenocarcinoma were treated with a combination chemotherapy schedule of sequential methotrexate and 5-fluorouracil alternated with 4-epidoxorubicin and cisplatin. This scheme was active, with 7 partial responses leading to a response rate of 33% (±20%). In two cases the tumor became operable. No severe toxicity developed and the treatment was usually well tolerated.

ISSN:0735-7907    

DOI:10.3109/07357909009012074

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

AbstractThe purpose of this study was to test the qualitative and quantitative toxicity of lonidamine (L) and alpha-interferon (IFNα) when used together, and to observe any apparent synergistic activity in conventionally untreatable measurable metastatic cancer. Eleven patients (8 males and 3 females) were enrolled. There was one response seen as measured by conventional criteria. There is no evidence that these agents are additive at this dose schedule, nor is their apparent synergistic activity.

ISSN:0735-7907    

DOI:10.3109/07357909009012075

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909009012076

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor