摘要:

Several studies suggest that protracted continuous Infusion constitutes an important way to optimize the dose and the efficacy of 5-fluorouracil (5-FU) in metastatic cancer. Eighty-three women aged 27–76 (median age 55) with metastatic breast cancer were treated every 4 weeks with a continuous ambulatory venous infusion of 5-FU 350 mg/m2/day and oral cyclophosphamide 100 mg/m2/day over 15 days. The continuous therapy was associated with a weekly administration of vincristine (0.8 mg/m2) and doxorubicin (15 mg/m2) on day 1, day 8, and day 15. Cycles were repeated every 28 days. Thirty-four patients were treated in first-line metastatic chemotherapy and 49 in second-line. Toxicities included: mucositis (grade≤2) 23%, diarrhea (grade≤2) 7%, a hand-foot syndrome (grade≤2) 9%, alopecia (grade 3) 21%, neurological (grade≤2) 4%, grade 3 and 4 leukopenia 29%, and grade 3 and 4 thrombopenia 8%. Heart toxicity was only 3%. Catheter infection was observed in 1 case and 7 patients experienced thrombosis. The overall objective response rate (OR) was 48% and the complete response rate was 23%. The median duration of response was 10 months. The median survival was 16 months. Activity was better in naive than pretreated women (respectively, 55% and 42% of OR, p = 0.21). Analysis of responses according to the metastatic sites shows the pronounced efficacy on soft tissus diseases (skin recurrences 42%, lymph nodes 52%), and also in visceral metastases (hepatic 36%, lung 34%).

ISSN:0735-7907    

DOI:10.3109/07357909609018882

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Twenty-three patients with advanced squamous cell carcinoma of the head and neck who had received no prior chemotherapy were treated with carboplatin 350 mg/m2followed by cisplatin 50 mg/m2every 28 days. Twenty-one of 23 patients were evaluablefor response and toxicity. Eight patients (38%) achieved complete response (CR) or partial response (PR) with 2 CR and 6 PR. The overall median survival was 8.4 months (range 19 days-56% months). The major toxicity was hematological with grade III/IV granulocytopenia in 32% and grade III/IV thrombocytopenia in 32%. There was very little nonhematological toxicity and no nephrotoxicity. There were no therapy-related deaths. The combination carboplatin/cisplatin is tolerable in patients with squamous cell carcinoma of the head and neck, with objective responses in 38%; however, the response rate was not superior to single-agent carboplatin or cisplatin. Further studies with a higher dose of cisplatin should be considered.

ISSN:0735-7907    

DOI:10.3109/07357909609018883

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

To compare the diagnostic usefulness as markers of hepatocellular carcinoma (HCC) ofα1-antitrypsin, C-reactive protein, andα1acid glycoprotein (all determined by nephelometric methods), we studied 132 subjects (74 male, 58 female): 43 had mild chronic liver disease, 32 cirrhosis, 24 HCC; 33 were controls. A total of 29.2% of the patients with HCC hadα1-acid glycoprotein>100 mg/dl, 75.0% hadα1-antitrypsin<220 mg/dl, 70.8% had C-reactive protein0.0001, respectively).α1-fetoprotein performed better than all acute-phase proteins. We conclude that, due to their low specificity and/or sensitivity, none of the three acute-phase reactants tested can be recommended for diagnostic use as biological markers of HCC in Western patients.

ISSN:0735-7907    

DOI:10.3109/07357909609018884

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

We presentαcase report of a child who developed acute lymphoblastic leukemia, neurofibromatosis, optic glioma, and Xanthogranulomatosis. This complex is unusual, not previously described, and appears to be a coincidence of different diseases. The importance of this case is that it may offer a clue to the genetic base of neurofibrosis syndromes including leukemic associations.

ISSN:0735-7907    

DOI:10.3109/07357909609018885

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

We report a patient with pulmonary and cutaneous lymphomatoid granulomatosis with central nervous system (CNS) involvement manifesting as central diabetes insipidus and review other cases reported in the literature with attention to presence of endocrine manifestations and response to therapy. Imaging of the pituitary in our patient demonstrated a thickened hypophyseal stalk and empty sella appearance. CHOP chemotherapy proved to be an effective treatment for both the systemic and CNS involvement in our patient, but diabetes insipidus has persisted. We postulate that there was localized involvement of the stalk of the hypophysis by lymphomatoid granulomatosis, which led to a permanent lesion causing diabetes insipidus. We conclude that lymphomatoid granulomatosis may cause endocrine complications that may not resolve despite systemic remission, and while the optimal regimen for CNS involvement with lymphomatoid granulomatosis is unknown, certain patients can have long-term survival after treatment with systemic chemotherapy.Endocrine complications of malignant diseases often present diagnostic and therapeutic challenges to the internist and neuro-oncologist. Lymphoproliferative disorders such as lymphomatoid granulomatosis and malignant lymphomas may cause generalized illness, which may complicate the recognition of neurological and endocrine abnormalities. Once central nervous system (CNS) involvement is documented, there is controversy regarding which therapeutic approaches are indicated to treat the CNS lesions and the systemic disease. We present a patient with lymphomatoid granulomatosis involving the pituitary hypophysis and review the literature to search for a consensus on the best treatment of CNS involvement.

ISSN:0735-7907    

DOI:10.3109/07357909609018886

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909609018887

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909609018888

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909609018889

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909609018890

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909609018891

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor