摘要:

Chemotherapy for squamous cell carcinoma with unknown primary (SCUP) has not been prospectively studied. To evaluate the efficacy of cis-diaminedichloroplatinum (cisplatin) and 5-fluorouracil (5-FU) in advanced SCUP, we treated 15 patients with measurable disease. A prospective trial was conducted of cisplatin and 5-FU in patients presenting with SCUP. All patients had evaluation in search for primary disease with computed tomographic scan of the head, neck, and chest and endoscopic evaluation of the nasopharynx, larynx, esophagus, and tracheobronchial passaes with negative blind biopsies. Chemotherapy consisted of cisplatin 100 mg/m2on day 1 and 5-FU 1000 mg/m2continuous infusion over 24 hr for 4 days. The regimen was repeated every 21 days. Responses were seen in 8 of 1.5 patients [1 complete response (CR) and 7 partial responses (PR)], for an overall response rate of 53%. These results suggest that cisplatin-5-FU combination has efficacy in advanced SCUP and deserves further trials both in advanced disease and in combined modality programs with surgery and radiation therapy.

ISSN:0735-7907    

DOI:10.3109/07357909509094459

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

A 10-year follow-up analysis has been performed on the cohort of 13 previously reported inflammatory breast cancer patients treated with chemotherapy, surgery, and allogeneic tumor cell/BCG vaccine. Follow-up of this duration is uncommon in the literature. Data indicate an apparent plateau of the survival curve at about 5 years, with 4 of 13 patients (31%) still alive after 10 years. Also noted is a long-term survival of an of-protocol padient with metastatic breast cancer treated with chemotherapy and vaccine. Although the role of vaccine cannot be directly determined from this study, this trial did demonstrate that long-term survival is a feasible goal for a significant fraction of patients with inflammatory breast cancer.

ISSN:0735-7907    

DOI:10.3109/07357909509094460

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

Fourteen patients with advanced ovarian cancer who failed chemotherapy received a long-acting LHRH agonist. All the patients had been previously operated on and all had received at least one regimen of chemotherapy. Duration of decapeptyl administration was between 1 month and 28 weeks. There were no complete or partial responses. Eight patients (57%) had disease stabilization with a median progressionfree interval of 14 weeks (range 4–28 weeks). All other patients developed a clear progressive cancer after the first injection of LHRH agonist. Three of these patients are still alive and receiving other forms of chemotherapy (median follow-up after rhe end of LHRH treatment was 11.5 months). The regimen was well tolerated with only mild toxicity observed (hot flushes in 2 patients). Although D-Trp-6-LHRH (Decapeptyl) was well tolerated, it had insignificant activity in treating patients with epithelial cancer that was resistant or relapsed after first-line platinum-based chemotherapy.

ISSN:0735-7907    

DOI:10.3109/07357909509094461

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

There is no known effective salvage chemotherapy for patients with refractory or relapsed urothelial tumors after methotrexate/cisplatin-based regimen. We report the results of a phase II trial with the FIFO regimen that includes from day 1 to 5: jluorouracil 350 mg/m2,folinic acid 20 mg/m2, and ifosfamide 1000 mg/m2,Q4W. Fifteen patients with metastatic measurable urothelial cancer were enrolled in this trial. Previous therapy included M-VAC regimen in 11 patients, CMV regimen in 3 patients, and both regimens in 1 patient. Thirty-one courses were delivered. Toxicity was moderate, including encephalopathy grade 2 in 2 patients and hematological toxicity grade 3 in 2 others. However, an early death occurred on day 1 in a patient who progressed rapidly and died from hepatic insuflciency after initial encephalopathy. No objective response was seen. Twelve patients progressed during FIFO therapy and 3 patients experienced a stable disease. Despite almost encouraging results of fluorouracil and ifosfamide in the literature, their combination according to our schedule is not active in urothelial cancer.

ISSN:0735-7907    

DOI:10.3109/07357909509094462

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

Cells of a breast adenocarcinoma cell line, CAMA-IEe, were found to contain a moderate concentration of 1, 25-dihydroxyvitamin D3[1, 25(OH)2D3] receptors. The receptors' dissociation constant calculated by Scatchard analysis was 4.1a10−10M. These receptors sedimented at around 4.0 S position on a linear 5–20% sucrose density gradient and exhibited an apparent molecular weight of about 46 kDa. Receptor concentration was found to be highest in the early stages of cell growth, decreased continuously when cells were actively growing, and reached the lowest level at confluence. Suppression of cell growth, of DNA synthesis, and of the phosphorylation of retinoblastoma protein by 1, 25(OH)2D3 at concentrations about 10−7M were observed. Treatment with 10−7M 1, 25(OH)2D3 for 12 hr or longer caused elevation of cytosolic free calcium in CAMA-IEe cells. These results show that CAMA-IEe cell growth is suppressed by 1, 25(OH)2D3 and that the suppression is possibly mediated through calcium mobilization.

ISSN:0735-7907    

DOI:10.3109/07357909509094463

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909509094464

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909509094465

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

摘要:

Advances in antiemetic therapy for cancer patients have been hindered by a lack of understanding of the physiological mechanisms associated with nausea and their corresponding measurement techniques. Here we review conceptual and methodological issues involved in developing an autonomic frame of reference for nausea and outline two strategies for assessing autonomic function. A primarily research-oriented strategy uses heart rate, blood volume pulse, pallor, and skin temperature to assess autonomic activity and reactivity over 24 hr. Peak values of these measures relative to time of emesis, heart rate spectral analyses of autonomic activity, and analyses of the standard deviation of successive differences of beat-to-beat intervals were all associated with subsequent nausea. A primarily clinically oriented strategy assesses normal and abnormal results on eight common bedside clinical tests of autonomic function. The total number of abnormal tests was associated with subsequent nausea. A better understanding of chemotherapy side effect mechanisms is likely to result in less polypharmacy and more effective individualized treatment for cancer patients.

ISSN:0735-7907    

DOI:10.3109/07357909509094466

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909509094467

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909509094468

出版商:Taylor&Francis    

年代:1995

数据来源: Taylor