摘要:

AbstractThe menstrual cycle, pregnancies, and offspring were evaluated before and after initial combined radiation (RT) and chemotherapy with thiotepa, vinblastine, vincristine, procarbazine, and prednisone (TVPP), in 34 women between the ages of 18 and 44 (median 26.5 years) treated for Stage II and Stage III Hodgkin's disease. The median range of follow-up is 83.1 months (range 40.5-140). After therapy 94.1% (32/34) continued to menstruate. Two of the four patients over the age of 35 ceased to menstruate. All patients under the age of 35 continued to menstruate (30/30). Age at the time of diagnosis was the only factor affecting change in menses with a significant probability (p=.001) that women>30 years of age will experience some change in menstrual pattern. Seventeen pregnancies occurred in 12 women after therapy; 2 had 4 elective abortions; 10 delivered 12 children with normal physical development; I will deliver six months from now. Twelve of thirteen patients who wanted to become pregnant have conceived. The ability to become pregnant and deliver normal children after intensive treatment with combined radiation and chemotherapy (RT/TVPP) was comparable to the patients' pretreatment record.

ISSN:0735-7907    

DOI:10.3109/07357908609038252

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

摘要:

AbstractSister chromatid exchange (SCE) analyses were carried out in hospital nurses to determine whether an increased frequency of SCE may be used as an indicator of occupational exposure to potentially harmful antineoplastic drugs. In our study of 18 oncology nurses who handled these agents for an average of three days per week, we found no increase in mean SCE frequency (9.3±1.7 SCEs/cell) and no difference in the distribution of individual mean SCE frequencies compared to a group of 18 nurses who did not handle these drugs (9.5±1.5 SCEs/cell). There was a great deal of individual variation in mean SCE frequency as well as in SCE values in individual cells. No relationship with SCE frequency was found in terms of a subject's age, or the number of days of exposure to the drugs. Since conflicting results have been reported in persons handling antineoplastic drugs, SCE analysis alone is probably not a reliable indicator of exposure to possible mutagenic/carcinogenic effects of these drugs. SCE analysis may be helpful in conjunction with other studies, such as an analysis of urinary mutagens, or in studies of occupational exposure to agents other than antineoplastic drugs which may have a more noticeable effect on SCE frequency.

ISSN:0735-7907    

DOI:10.3109/07357908609038253

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

摘要:

AbstractIntragastric feeding of dimethylbenz-[a]anthracene in corn oil together with urethane in the drinking water and forced breeding were successful in rapidly inducing (2-4 months) mammary tumors (adenoacanthomas) in inbred NYLR/Nya mice, which have a low incidence of spontaneous breast tumors and of other tumors. The tumors could be quickly and permanently transformed to an ascites form by intraperitoneal inoculation of enzyme-dissociated cells and subsequent serial passage of free cells. Only 10 (3 in some cases) serial passages were required, thus conveniently providing multiple isogeneic carcinoma cell lines in this strain of mice. Some tumor cell lines proliferated strongly in the abdominal cavity even on the first passage.

ISSN:0735-7907    

DOI:10.3109/07357908609038254

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609038255

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609038256

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609038257

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609038258

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609038259

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609038260

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609038261

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor